Patents Represented by Attorney Brian P. O'Shaughnessy

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  • Treatment of AIDS-type disease
    Patent number: 4921837
    Abstract: Disclosed herein is the treatment of patients suffering from AIDS-type disease with a colony stimulating factor alone or together with erythropoietin, and/or an anti-viral agent and/or IL-2.
    Type: Grant
    Filed: July 24, 1987
    Date of Patent: May 1, 1990
    Assignee: Genetics Institute Inc.
    Inventor: Robert E. Donahue
  • Novel composition for nucleic acid purification
    Patent number: 4843012
    Abstract: A storage stable single phase aqueous composition is provided which is useful in isolatin nucleic acids from cell or virus cultures.
    Type: Grant
    Filed: September 17, 1986
    Date of Patent: June 27, 1989
    Assignee: Genetics Institute, Inc.
    Inventors: David A. DeBonville, Gerard E. Riedel
  • Method for the isolation and purification of DNA molecules
    Patent number: 4833239
    Abstract: A method for isolating and purifying nucleic acids from eukaryotic and prokaryotic cell cultures or viral cell cultures.
    Type: Grant
    Filed: January 29, 1987
    Date of Patent: May 23, 1989
    Assignee: Genetics Institute, Inc.
    Inventors: David A. DeBonville, Gerard E. Riedel
  • High yield production of active Factor IX
    Patent number: 4770999
    Abstract: High yields of active Factor IX are produced by culturing a CHO cell line transfected with chromosomally-integrated Factor IX cDNA in medium to which vitamin K is added.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: September 13, 1988
    Assignee: Genetics Institute, Inc.
    Inventors: Randal J. Kaufman, Charles B. Shoemaker, Louise C. Wasley
  • Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide
    Patent number: 4752566
    Abstract: A method for determining the presence and amount of a predetermined target nucleotide sequence in a biological sample is provided. The method employs a reagent complex which consists of a labeled probe polynucleotide having a target binding region and a second polynucleotide bound to the labeled probe in a second polynucleotide binding region thereof. The second binding region is at least partially coextensive with the target binding region. This reagent complex is contacted with a sample under conditions in which the target sequence binds to the labeled probe, displacing the second polynucleotide. Labeled probe/target hybrids are separated from intact reagent complexes and the presence and amount of these hybrids are determined.
    Type: Grant
    Filed: December 17, 1985
    Date of Patent: June 21, 1988
    Assignee: Genetics Institute, Inc.
    Inventors: Mary Collins, Joseph P. Dougherty