Abstract: A cyanoacrylate adhesive composition is disclosed which has a lowered adhesion to the skin and contains at least one compound selected from the groups mentioned below and an anionic polymerization accelerator: A: An aliphatic alcohol having an aliphatic group in which 6 or more carbon atoms are directly bonded with each other; B: An aliphatic carboxylic acid ester having an aliphatic group in which 6 or more carbon atoms are directly bonded with each other; C: An aliphatic carboxylic acid ester having at least 2 aliphatic groups in which 4 or more carbon atoms are directly bonded with each other; and D: A carboxylic acid ester of a carbocyclic compound having, in a carboxylic acid residue or alcohol residue, an aliphatic group in which 5 or more carbon atoms are directly bonded with each other.

Abstract: Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass of Retinoic Acid Receptors (RARs). Examples of such compounds are bicyclic benzyl, pyridinyl, thiophene, furanyl, and pyrrole derivatives. The disclosed methods employ compounds for modulating processes selectively mediated by Retinoid X Receptors.

Abstract: A coupling device for connecting a handle part and a tool part includes a plug and a socket. The plug has a main portion, an end portion, and a notched portion between the main portion and the end portion. The socket has a proximal base end, a body portion, and a locking member. The body portion extends from the base end and has an axial, plug receiving bore that opens through a distal end of the body portion. The locking member is positioned between the base end and the plug receiving bore. The locking member includes a leaf spring cantilevered axially on one side of the body portion of the socket. The leaf spring supports a latch bar that engages the notched portion of the plug when the plug is inserted through the open end of the plug receiving bore. The latch bar is spaced from the leaf spring so that the end portion of the plug passes between the latch bar and the leaf spring when the plug is inserted through the open end of the plug receiving bore.

Abstract: This invention relates to methods and compositions for the treatment of non-insulin-dependent diabetes mellitus using an RXR agonist alone or in combination with a PPAR&ggr; agonist such as a thiazolidinedione compound.

Abstract: Prodrugs of formula I, their uses, their intermediates, and their method of manufacture are described:

Abstract: A total elbow arthroplasty system, incorporating a humeral component, a radial component and a ball component, may be used as a total elbow replacement in the canine, as well as in other species. The implant of the present invention has an isometric humeral component and an isometric radial component. An isometric ball component having an isometric articular surface is mounted on the radial component. The humeral and radial components have stems for mounting in the medullary canals of the respective bones, which are angled so as to approximate the configuration of the original humerus and radius. The components work together to form a nonconstrained ball and socket joint. The invention is also directed to methods for implanting the novel endoprosthesis of the present invention in a canine elbow joint. The apparatus and methods of the present invention are useful in the treatment of elbow osteoarthritis in canines, as well as in other species, including other quadrupeds and humans.

Abstract: The present invention is directed towards novel azaindole compounds which bind to the AMP site and are potent FBPase inhibitors. The present invention also is directed towards the clinical use of the novel FBPase inhibitors as a method of treatment or prevention of diseases responsive to lowered blood glucose levels.

Abstract: The present invention provides pure, storage stable, reactive esters of 2-cyanopenta-2,4-dienoic acid and the adhesives and polymers thereof. The monomers of the present invention have the formula: where R is alkyl, alkenyl, alkynyl, alkoxyalkyl, alkenyloxyalkyl, alkynyloxyalkyl, poly(oxyalkyl), aryl, cycloalkyl or a heterocyclyc radical. R may also be one of the foregoing moieties substituted with one or more of the other moieties; this includes the case of the substituent itself being substituted, and may also contain halogens. The reactive monomers of the present invention can be formulated into adhesives by incorporating certain modifiers and additives such as polymeric thickeners, viscocity regulators, plasticizers, thixotrophic agents, compatibilizers, adhesion promoters, pigments and colorants, fillers, deodorants and perfumes. They can also be used in composition with other monomers containing a reactive double bond such as for example cyanoacrylates.

Abstract: Methods are provided for screening pigs to determine those more likely to produce larger litters. The screening method detects the presence of particular alleles in the genome, and in a preferred embodiment, the screening is performed by nucleic acid analysis. Specific primers as well as kits for carrying out the methods of the invention are also provided.

Abstract: A computer management system capable of managing computer programs, computer files, computer settings, peripheral settings and the like is controlled through the use of agents on the computers and a remote accessing program. The remote accessing program, in a preferred embodiment, can be a commercial web browser. The user can use the remote accessing program from any computer to reach the agent on the computer. After being recognized by the agent, the user can make any adjustments to the computer through the agent.

Abstract: Novel purine compounds of the following structure and their use as fructose-1,6-bisphosphatase inhibitors is described.

Abstract: A methyacryloyl or acryloyl derivative of an ester of cyanoacetic acid may be of the formula: CN—CH2—COOR2OCOCR1═CH2. R1 may be H or CH3, and R2 may be one of the group of moieties including alkyl, alkenyl, alkynyl, alkoxyalkyl, poly (oxyalkyl), aryl, cycloalkyl, and heterocyclyc radical, or substitited combinations thereof. Further, R2 may include between 1 and 16 carbon atoms or heteroatom ring members.

Abstract: Novel compositions extracted from corn products provide contraceptive and anti-neoplastic activities. Using novel extraction procedures, compositions may be isolated from corn products. For example, a Zea mays plant product is extracted in a first solvent to produce a solvent extract, the solvent extract is dried to produce an extracted solid, the extracted solid is solubilized in a second solvent, the solubilized extract is purified in a chromatographic process, and an active fraction is collected from the chromatographic process. Compositions may be applied to animal bedding or food, and are adaptable to any suitable method of administration. The contraceptive activity of these compositions is effective for both males and females.

Abstract: A method for preparing C(5)-substituted 1,2-dihydro-5H-chromeno[3,4-ƒ]quinolines from a lactol precursor is provided. The method comprises converting the lactol to one of a select number of mixed acetal derivatives, and then treating the acetals with a Grignard reagent. The new process provides products in higher yield and greater purity. Novel intermediates of this method are also claimed.

Abstract: An electromagnetic shielding composite having nanotubes and a method of making the same are disclosed. According to one embodiment of the present invention, the composite for providing electromagnetic shielding includes a polymeric material and an effective amount of oriented nanotubes for EM shielding, the nanotubes being oriented when a shearing force is applied to the composite. According to another embodiment of the present invention, the method for making an electromagnetic shielding includes the steps of (1) providing a polymer with an amount of nanotubes, and (2) imparting a shearing force to the polymer and nanotubes to orient the nanotubes.

Abstract: The present invention relates to mashed potato products that are provided, in at least a top portion, with a browning agent that causes the product to achieve a pleasing golden brown color upon heating in either a microwave or conventional oven. The product can be a mashed potato topped pot pie.

Abstract: A pilot computer can control the Web browser of at least one passenger computer. The user of the passenger computer is instructed to log onto a control site, which downloads an active control, such as an applet, to the passenger computer. An active control is also provided to the pilot computer. If the pilot computer desires to present a particular Web page to both the pilot computer and the passenger computer for, e.g., discussing the page during a conference call, the pilot computer transmits the appropriate URL to the control site, which then retrieves the Web page. Next, the control site sanitizes the page by disabling its hyperlinks, and then the control site causes the passenger computer's active control to download the sanitized page. Also, the control site filters the page such that the hyperlinks are not disabled, but are rather encoded to point back to the control site, and this filtered page is downloaded to the pilot computer.

Abstract: The invention includes a tool holder for at least one tool having a working end and a handle. The tool holder comprises a gripping device for the handle of the at least one tool, a base for supporting the working end of the at least one tool, and a substantially vertical structural support connected to the gripping device and the base for supporting the gripping device vertically upward from the base. The base includes an irregular surface for contacting an edge of the working end of the at least one tool, thereby restricting movement of the working end of the at least one tool along the base.

Abstract: A medicinal combination of one or more nucleic acids that at least partially inhibit oncogenic cell signalling pathways, and a therapeutic anticancer agent, for use simultaneous, separate or over a period of time to treat hyperproliferative diseases.

Abstract: A 1×N mechanically actuated optical switch includes a plurality of optical reflectors, at least some of which are movable between their on and off positions to switch an input optical signal to any one of a plurality of output optical fibers selected for outputting the optical signal.