Abstract: The present invention relates to a method for the selected chemical activation of photo-activatable cross-linker molecules around ligand binding pockets and fluorescent groups in macromolecules, especially biological macromolecules, by using fluorescent ligands of the macromolecule and by selecting photo-activatable cross-linker molecules having specific activation energies so that a radiationless energy transfer (Förster transfer) from the fluorescent ligands to the cross-linker molecules, which become activated thereby, takes place.

Abstract: Dimer-selective RXR modulator compounds having agonist, partial agonist and/or antagonist activity in the context of an RXR homodimer and/or RXR heterodimers are provided. Also provided are pharmaceutical compositions incorporating such dimer-selective RXR modulator compounds and methods for their therapeutic use.

Abstract: A collaborative Web browsing session may take place over a network, allowing the presenter on a first computer to direct the audio and visual components of a browser on one or more second computers. The second computer is instructed to log into a control site that downloads an active control, such as an applet, to the second computer. The present invention allows a collaborative Web browsing session (“session”), as created by the presenter and witnessed by one or more users on second computers, to be recorded and archived by the control site. When a user of a computer is connected to the control site through a communication network such as the World Wide Web, that user may log into the control site and request to view an archived session. The session will then be replayed by the control site on the user's computer, directing the audio and visual components of the browser on the user's computer as if the user was attending the live session.

Abstract: Non-steroidal compounds that are high affinity, high selectivity modulators for androgen receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring androgen receptor agonist, partial agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the androgen receptor modulator compounds.

Abstract: This invention relates to methods and compositions for the treatment of non-insulin-dependent diabetes mellitus using an RXR agonist alone or in combination with a PPAR&ggr; agonist such as a thiazolidinedione compound.

Abstract: This invention is directed to a novel method for direct in vivo electrotransfection of a plurality of cells of a target tissue. In the method, the target is perfused with a transfection solution. An exterior electrode is positioned so as to surround at least a portion of the target tissue. One or more interior electrodes are placed within the target tissue. The perfusion and the application of the interior and exterior electrodes may be performed in any particular order. After the perfusion and the positioning of the electrodes, both interior and exterior, an electric waveform is applied through the exterior electrode and the interior electrode to transfect the cells in the target tissue.

Abstract: A diode for improved electrostatic discharge (ESD) protection against current failure includes a plurality of elongate anode and cathode conductor stripes each having first and second end portions of different widths to reduce current densities at feeder bus tie points, thereby reducing the possibility of current failure.

Abstract: Methods for treating gestational diabetes which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that lower blood glucose levels.

Abstract: This invention provides the isolation and characterization of a tumor associated antigen which can be used for immunodiagnosis, immunoprognosis, and therapy of human cancer. The antigen is a protein molecule with a molecular weight of about 35 kD after reduction and separation by SDS-polyacrylamide gel electrophoresis. The antigen has been detected in serum of cancer patients.

Abstract: FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose or excess glycogen storage.

Abstract: The present invention is drawn to hot-melt adhesives for bonding vitreous plastic materials to thermoplastic or thermosetting plastic materials, and to the use of these adhesives for making vehicle lamps or headlamps comprising lenses, especially bearing a scratch-proofing coating, made of a vitreous plastic material, and lamp bodies made of a thermoplastic or thermosetting plastic material, where the lenses and lamp bodies are bonded together with these hot-melt adhesives. The hot-melt adhesives of this invention are characterized in that they contain: a) from 0.5 to 15% by weight of optionally grafted thermoplastic elastomers; b) from 5 to 40% by weight of optionally grafted poly-&agr;-olefins except polyisobutylene; c) from 5 to 45% by weight of adhesive resins; and d) from 5 to 55% by weight of polyisobutylenes.

Abstract: The present invention relates to orally administerable medicinal plant dry extracts, wherein the non-volatile phase of the extract is bound in a microdisperse form and/or in the form of a semisolid or solid solution to a first carrier which is soluble in or miscible with alcohol, soluble in or miscible with water and solid at room temperature, optionally in addition to other auxiliaries and/or additives. Optionally, a second carrier is selected from carriers which are insoluble in alcohol, insoluble in water or swellable in water and solid at room temperature, or alkaline earth metal and/or alkali metal carbonates including hydrogencarbonates.

Abstract: Sterile pharmaceutical compositions for parenteral administration containing 2,6-diisopropylphenol (propofol) are described for use as anesthetics. The compositions comprise an oil-in-water emulsion of propofol additionally comprising an amount of sulfite sufficient to prevent significant growth of microorganisms for at least 24 h after adventitious contamination.

Abstract: The present invention relates to an impermeable flexible multicompartment bag for medical use for sterile solutions, and to a method for the preparation of such bags. Impermeable flexible multicompartment bags for medical use for sterile solutions for perfusions, consisting of two welded sheets of a composite material wherein the sheets forming the inner wall of the bag consist of a polypropylene and are bonded to an outer layer of a thermoplastic polymer by means of a polyolefin layer, characterized in that the sheets facing the contents of the bags which are made of a homophase copolymer of propylene are immediately welded in the intercompartment region and in the peripheral region such that the weld forming the intercompartment region can be ruptured with a force in the range of from 10 to 30 N while the weld in the peripheral region cannot be ruptured.

Abstract: Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.

Abstract: Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

Abstract: The present invention relates to a process for recycling fillers and coating pigments from the preparation of paper, paperboard and cardboard found in the residual water sludges from coating plant waste waters, deinking plants, internal water treatment plants or separators, and to the use of a thus obtained pigment slurry for the preparation of a coating compound for the paper industry or in the paper stock for papermaking. An essential element of the invention is a process for recycling fillers and coating pigments from the preparation of paper, paperboard and cardboard found in the residual water sludges from coating plant waste waters, deinking plants, internal water treatment plants or separators, characterized in that the residual water sludges containing the fillers and coating pigments are subjected to mixing and then milling together with fresh pigments or fresh fillers in the form of powders, fresh-pigment containing slurries and/or fresh-filler containing slurries to yield a pigment slurry.

Abstract: The present invention provides a compound of the formula: and methods for using the same, wherein R1, R2, R3, R4 and X are those defined herein.

Abstract: An M×N mechanically actuated optical switch matrix includes a plurality of optical reflectors arranged in an array comprising a plurality of columns and rows, at least some of which are movable between their on and off positions, a plurality of primary optical ports and a plurality of secondary optical ports. More than one optical reflector may be switched on simultaneously to establish optical signal channels between respective primary and secondary optical ports.