Patents Represented by Attorney Browdy & Neimark, PPLC

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  • Erythromycin derivative having novel crystal structures and processes for their production
    Patent number: 7645864
    Abstract: The present invention provides an E-type crystal of N-demethyl-N-isopropyl-12-methoxy-11-oxo-8,9-anhydroerythromycin A-6,9-hemiacetal fumarate having strong diffraction peaks at diffraction angles (2?) of 5.6° and 10.4° as measured by powder X-ray diffractometry, which is prepared by treating a C-type crystal of the compound in a mixed solvent of ethyl acetate and water at 20° C. to 40° C., and a D-type crystal prepared via the E-type crystal. These crystals have a reduced content of residual solvent and high suitability for formulation.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: January 12, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Akira Hiraide, Kaichiro Koyama, Hitoshi Shimizu, Kaname Tsuzaki