Abstract: The present invention relates to a method and an arrangement for the determination of the optical properties of a multi-layered tissue. More specifically, the invention relates to a method for the detection and characterisation of tumors in a tissue.

Abstract: A suturing instrument is configured for to apply sutures to approximate, ligate, or fixate tissue in, for example, open, mini-incision, trans-vaginal, or endoscopic surgical procedures. The suturing instrument includes an elongate body member, a needle exit port, a needle receiving port, and a needle deployment mechanism. The suturing instrument eliminates the need for a preassembled needle and suture and reduces or eliminates the possibility of needle loss during suturing.

Abstract: A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30° C.

Abstract: Apparatus for monitoring a selected tier in a multi-tier computing environment, the apparatus including a context agent and a dynamic tier extension, the context agent associated with the selected tier and coupled with other context agents, each of which is associated with a respective tier, the dynamic tier extension coupled with the context agent and with specific predetermined points of the selected tier, the dynamic tier extension monitoring request traffic passing through the selected tier, the monitored request traffic including at least one entering request received at a request entry port from an adjacent tier, the dynamic tier extension identifying each request in the monitored request traffic and sending at least a request identifier to the context agent, the context agent also receiving information relating to the request context of the entering request from the context agent associated with the adjacent tier, the context agent associating the information relating to the request context of the ente

Abstract: The disclosure provides methods of reducing the range of representation levels of nucleic acid targets. The methods are particularly useful for multi-target analyses benefiting from a low variance of target representations, such as, e.g., single molecule sequencing and/or heterozygous genotyping, and pathogen diagnosis. Two general methods are provided. In Method 1, starting concentrations of probes are adjusted. In Method 2, target-specific probes are “binned,” i.e., several subsets of probes are selected based on similar representation levels. Thereafter, each subset of corresponding targets is extracted, with or without amplification, using a separate portion of the sample (i.e., separate vessels).

Abstract: A skirt for a material transport system, eg conveyor belt (104), includes liner plates (111, 112) mounted on the conveyor side of body (200). Removal of certain plates (112) only requires access via the side of body (200) away from conveyor (104). To remove plate (112) requires removal of its support member (210) as well and so provides an aperture through which a workman can insert his hand to remove further plates (111, 112). Member (210) may be hel to body (200) using wedges inserted through eyes and this member (210) may be positioned with the aid of tabs and guides. Rubber dust seals are also provided which are clamped in place using plates and wedge arrangements. These seals must be removed prior to removal of liner plates (111, 112).

Abstract: A media display system and method is provided. The media display system comprising a two wheeled base configured for a operator to stand on; a steering column operatively connected to said base; a display means for a user standing on said base to hold and steer, said display mean allowing messages to be displayed; a handle operatively connected to said display means; and at least one wheel operatively connected to said media display such that said media display system can move 365 degrees.

Abstract: Sutures can be placed in difficult to access areas of the human body with devices, and related methods, utilizing a suture carrier with a sharpened tip and a notch for holding a formed suture tip. The devices and methods can be used in conjunction with both endosurgical and traditional open surgery.

Abstract: An embodiment of the invention includes an entry needle. The entry needle may include a cannula, a needle extending within a lumen of the cannula, and a hub operatively associated with a proximal portion of the cannula. The hub may include a branch in communication with the lumen of the cannula. The needle may be movable between a first position and a second position. In the first position, the needle may prevent communication between an opening in an outer wall of the cannula and the branch. In the second position, the needle may allow communication between the opening in the outer wall of the cannula and the branch.

Abstract: The invention provides nucleotide analogs and methods of using them in sequencing reactions.

Abstract: The disclosure provides methods of generating paired reads in sequencing-by-synthesis process, particularly, in systems with relatively short read lengths (e.g., 15-35bases), such as for example, in single molecule sequencing by synthesis. Several implementations of the methods are provided. Of particular advantage are the methods that permit re-sequencing of the template, which yields lower error rates. The invention further provides methods of using paired reads, for example, for positioning them over repeats or for assembly into large sequences, including whole genome assembly.

Abstract: A liquid storage apparatus provides a safe and easy to use device for efficiently managing liquid reagents used in a variety of laboratory equipment. The liquid storage apparatus helps reduce the likelihood of accidental sticks to laboratory personnel, allows for flexibility of experimental design, and helps maximize the use of chemical regents to prevent waste. The apparatus includes a plurality of containers of liquid with a pierceable septum interface at each end. The apparatus also includes a lower array of needles with each of the lower needles in the lower array of needles arranged to penetrate the bottom pierceable septum of a different one of the containers. Each of the needles includes a passage so the liquid can flow out of the pierced container. The apparatus further includes an upper array of needles with each of the upper needles in the upper array of needles arranged to penetrate the top pierceable septum of a different one of the containers.

Abstract: A computer-assisted method of establishing a brand presence in a facility. The method includes accessing, by facility personnel, a computer having a playlist that controls the playback of audio and video broadcasting within the facility and entering on the playlist, by facility personnel, identifiers of advertisements related to the facility.

Abstract: A urethral prosthesis with prostatic and bulbar segments connected by two types of ties allows the prosthesis to assume at least two configurations different with inter-segmental distances adapted to situations where the patient either has or does not have normal control of the external sphincter. This is particularly useful for a patient undergoing an anesthetic procedure that affects the external sphincter muscles. When the muscles are anesthetized, the prosthesis may provide constant urine voiding, and when the anesthetic effects wear off, the prosthesis may assume a different configuration to allow the sphincter to reassert control over urinary voiding.

Abstract: This present disclosure provides an optical chip for fluorescence detection. The optical chip has one or more parabolic optical elements that capture and collimate the fluorescent light and direct it onto a detector. The optical chip may be constructed of a polymer and made using injection molding techniques.

Abstract: A method, system and apparatus including receiving a request from a network device, the request including an IP address of said network device, generating and sending to the network device a domain name for locating a device configured to process a DNS query, the domain name corresponding to the IP address, the network device generating and sending a DNS query including the domain name and at least one local DNS setting of the network device to the device configured to the process the DNS query, and the device processing an association between the IP address and the at least one local DNS setting of the network device.

Abstract: A method for creating an ordered reading list of predetermined length of relevant topics from a hyperlinked database source of information website for a user. The method includes determining at least one topic of interest based on a plurality of methods and choosing a topic ordering algorithm from a plurality of topic ordering algorithms. A top-down schematic algorithm includes a page rank calculation performed by iterating until a convergence. A bottom-up schematic algorithm includes a linear parameterization of a ratio of an order from a plurality of source topics to a plurality of sink topics of an article, and a horizontal schematic algorithm includes an order parameterization by absolute differences of a log of a plurality of ranks and an absolute difference of a plurality of distances with analogous cutoff methods.

Abstract: The disclosure provides nucleotide analogs and methods of their use. Analogs of the invention comprise a reporter molecule (label) attached via the N4, N6, O4, or O6 position of the nitrogenous base portion of the analog. In a preferred embodiment, nucleotide analogs of the invention comprise a label attached to the nitrogenous base portion of the analog via a cleavable linker at the N4, O4, N6 or O6 position.