Patents Represented by Attorney Bruce F. Jacobs
  • Patent number: 7101937
    Abstract: Macromolecules in the shape of three-dimensional kites, barbells, and other shapes are disclosed. The shaped macromolecules are prepared the reaction of one or more dendritic polymers and a linear polymer. The kite-shaped macromolecules are dendritic polymers attached at either their focal points or at an outer to a long carbon chain group. The barbell macromolecules have dendritic polymers at either end of the molecule, which polymers are connected together through the focal points of each by a suitable connecting substituent such as a linear polymer. The shaped macromolecules are used in specialty medical and technological applications including such as drug delivery agents, imaging materials, molecular devices, thin film devices, surface modifiers, transport agents, compatibilizers, rheology control agents, molecular ball bearings, molecular dipoles, non-linear optical materials, medical imaging agents, membrane and cell modifiers, complexing agents, adhesives, interface strengthening agents, and the like.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: September 5, 2006
    Inventors: Jean M. J. Frechet, Craig J. Hawker, Karen Wooley
  • Patent number: 6971392
    Abstract: A tool for making gentle repetitive movements to the joints between a person's sacrum and ilium which allow for proper pelvic alignment when one or both have become irritated, inflamed, or malaligned, and causes significant pain. Use of the tool generates a lateral and caudal directed force on an affected ilium thereby mobilizing it back into its normal position. The tool also may be used to realign the pubic synthesis.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: December 6, 2005
    Inventors: Ronald P. Lindahn, Vicki Sims-Skorput
  • Patent number: 6872539
    Abstract: An analytical system for rapid detection and identification of different analytes directly from a test sample by mixing test material with a germinogenic source and enzyme-free spores, allowing the mixture to stand for a time to allow analyte-induced spore germination and subsequent de novo activity of an enzyme capable of producing a germinant in the presence of the germinogenic source and detecting the presence of a germination-derived product. The germinant which is formed promotes further spore germination with concomitant additional de novo enzyme synthesis or activation which results in a propagating cascade of analyte-independent germination after which a germination-derived product can be easily detected. The technique is particularly efficient to conduct thousands of parallel assays in an array of microscopic wells.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: March 29, 2005
    Inventor: M. Boris Rotman
  • Patent number: 6670402
    Abstract: Methods of more rapidly producing aerogel products by means of a rapid solvent exchange of solvent inside wet gels with supercritical CO2 by injecting supercritical, rather than liquid, CO2 into an extractor that has been pre-heated and pre-pressurized to substantially supercritical conditions or above. Preferably, pressure waves are applied to the supercritical CO2 to enhance the solvent exchange. The rapid solvent exchange process is followed by depressurization, optionally with a gas exchange. Preferably, pressure waves are used to speed up the depressurization. The process greatly reduces the time for forming aerogel products.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: December 30, 2003
    Assignee: Aspen Aerogels, Inc.
    Inventors: Kang P. Lee, Redouane Begag, Zlatko Altiparmakov
  • Patent number: 6465050
    Abstract: A non-cracking hydrophilic polyether sulfone membrane is prepared by (a) directly coating the entire surface of a hydrophobic polyethersulfone membrane with an aqueous solution of a polyalkylene oxide polymer and at least one polyfunctional monomer, and (b) polymerizing the monomer over the entire surface of the membrane under conditions which cause the resulting polymer to attach to the polyethersulfone membrane and the polyethylene oxide to form a non-extractable surface which does not crack when the membrane is folded to form a pleated cartridge.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: October 15, 2002
    Assignee: Osmonics, Inc.
    Inventors: Michael J. Witham, James S. Johnson
  • Patent number: 6464828
    Abstract: Polyester water-based defoamers are prepared by reaction of a dimer fatty acid, a fatty acid and two different polyalkylene polyols, e.g. polypropylene glycol and polyethylene glycol. The resulting polyesters are readily dispersible in water to form a water-based macroemulsion in the absence of any oil or short chain alcohols. The macroemulsion is an effective defoamer in ground-wood and thermomechanical pulping operations.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: October 15, 2002
    Assignee: Callaway Chemical Corp.
    Inventor: Robert Furman
  • Patent number: 6387215
    Abstract: A process for controlling/reducing the deposition of stickies from paper stock suspensions in papermaking involving the steps of: (a) providing a paper stock suspension containing stickies; and (b) contacting the stickies in the paper stock suspension with a copolymer of about 75-95 wt % acrylamide and about 5-25 wt % vinyl acetate.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: May 14, 2002
    Assignee: Callaway Chemical Corporation
    Inventors: Gavin G. Spence, Alan J. Schellhamer, Stephen R. Kurowsky
  • Patent number: 6309608
    Abstract: Methods and apparatus for the semi-automated synthesis of libraries of organic compounds are disclosed. More specifically, the present invention comprises multi-vessel reaction blocks, accessory components, and complementary workstations designed to facilitate the semi-automated production of libraries of chemical compounds by combinatorial and parallel synthesis techniques. The invention is particularly well suited to the conduct of solid-phase or solution-phase parallel syntheses of single compounds and compound mixtures in a high-throughput manner.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: October 30, 2001
    Inventors: Peng Zhou, Stephen Matson
  • Patent number: 6300424
    Abstract: Hyperbranched polyester and polyamide polymers are prepared by a one-step process of polymerizing a monomer of the formula A—R—B2 so that high molecular weight globular polymers having a multiplicity of a particular functional group on the outside surface are obtained.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: October 9, 2001
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Jean M. J. Frechet, Craig J. Hawker, Kathryn Uhrich
  • Patent number: 6280851
    Abstract: Copper foil used in printed circuit boards is protected from contamination both prior to laying up the circuit board components and during processing by a multilayer protective film structure having a silicone adhesive disposed on one entire surface and a silicone release composition on the other entire surface.
    Type: Grant
    Filed: March 23, 1998
    Date of Patent: August 28, 2001
    Assignee: Sentrex Company, Inc.
    Inventors: Melvin Pasternack, Jurgen Matthes
  • Patent number: 6255291
    Abstract: A composition containing alph-alanine, adenosine compound and a glucan. Methods for treating cancer and immunological disorders with said composition.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: July 3, 2001
    Assignee: Peregrine Pharmaceuticals, Inc.
    Inventor: Yveta Germano
  • Patent number: 6228574
    Abstract: An analytical system for rapid detection and identification of different analytes directly from a test sample by mixing test material with a germinogenic source and enzyme-free spores, allowing the mixture to stand for a time to allow analyte-induced spore germination and subsequent de novo synthesis of an enzyme capable of producing a germinant in the presence of the germinogenic source and detecting the presence of a germination-derived product. The germinant which is formed promotes further spore germination with concomitant additional de novo enzyme synthesis which results in a propagating cascade of analyte-independent germination after which a germination-derived product can be easily detected. The technique is particularly efficient to conduct thousands of parallel assays in an array of microscopic wells.
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: May 8, 2001
    Inventor: M. Boris Rotman
  • Patent number: 6221332
    Abstract: Enhanced macromixing, mesomixing, and micromixing of multiple discrete reactant streams, particularly for precipitation reactions of low density pumpable fluids, are obtained by controlled continuous high pressure multiple reactant streams flowing into a chemical mixer/reactor. Individual reactant streams are pressurized to about 8,000 to 50,000 psi and achieve velocities up to about 250 meters/second in the final stage of the chemical mixer/reactor. Reactant flows are controlled by a combination of a fixed restriction and a variable driving pump.
    Type: Grant
    Filed: August 5, 1998
    Date of Patent: April 24, 2001
    Assignee: MicroFluidics International Corp.
    Inventors: Jeffrey R. Thumm, Michael A. Lento, Jerome S. Higgins
  • Patent number: 6222194
    Abstract: Methods of irradiating sapphire with fast neutron radiation to form a sapphire body having high compressive strength at elevated temperature and use thereof in sapphire window assemblies, bearing assemblies, semi-conductor devices, and optical fibers. The sapphire assemblies and methods for making them.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: April 24, 2001
    Assignee: Aspen Systems, Inc.
    Inventor: Thomas M Regan
  • Patent number: 6193077
    Abstract: A non-cracking hydrophilic polyether sulfone membrane is prepared by (a) directly coating the entire surface of a hydrophobic polyethersulfone membrane with an aqueous solution of a polyalkylene oxide polymer and at least one polyfunctional monomer, and (b) polymerizing the monomer over the entire surface of the membrane under conditions which cause the resulting polymer to attach to the polyethersulfone membrane and the polyethylene oxide to form a non-extractable surface which does not crack when the membrane is folded to form a pleated cartridge.
    Type: Grant
    Filed: February 8, 1999
    Date of Patent: February 27, 2001
    Assignee: Osmonics, Inc.
    Inventors: Michael J. Witham, James S. Johnson
  • Patent number: 6159442
    Abstract: Processes for use of a controlled continuous high pressure multiple reactant streams flowing into a chemical mixer/reactor. Individual reactant streams are pressurized to about 8,000 to 50,000 psi and achieve velocities up to about 250 meters/second in the final stage of the chemical mixer/reactor.
    Type: Grant
    Filed: August 5, 1998
    Date of Patent: December 12, 2000
    Assignee: MFIC Corporation
    Inventors: Jeffrey R. Thumm, Michael A. Lento, Jerome S. Higgins, David Lassen King, David Mark Ginter, Laurent DAny Kieken
  • Patent number: 6096802
    Abstract: The stability of colloidal metal oxide particles which have been encapsulated in a polymer resin is extended by the addition of a water-soluble polyacrylamide polymer.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: August 1, 2000
    Assignee: Callaway Corporation
    Inventor: John C. Lark
  • Patent number: 6095153
    Abstract: Vaporization of volatile materials while avoiding combustion and denaturation of such material provide an alternative to combustion as means of volatilizing bioactive and flavor compounds to make such compounds available for inhalation without generating toxic or carcinogenic substances that are by-products of combustion and pyrolysis.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: August 1, 2000
    Inventors: Stephen B. Kessler, T. David Marro
  • Patent number: 6077394
    Abstract: A method for making alkaline fine paper which comprises adding (i) a glyoxylated acrylamide-diallyldimethyl ammonium chloride resin and (ii) an aminopolyamide-epichlorohydrin resin to an alkaline fine paper pulp slurry containing filler material during a papermaking process, the resins being added in an amount and at a rate sufficient to increase the retention of the filler in the paper and drainage of process water from the slurry.
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: June 20, 2000
    Assignee: Callaway Chemical Corporation
    Inventors: Gavin G. Spence, Duane R. Palmateer, James R. Yarnell
  • Patent number: D506791
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: June 28, 2005
    Inventor: Yveta Germano