Patents Represented by Attorney, Agent or Law Firm Bruce Jacobs
  • Patent number: 6596496
    Abstract: An analytical system for rapid detection and identification of different analytes directly from a test sample by mixing test material with a germinogenic source and enzyme-free spores, allowing the mixture to stand for a time to allow analyte-induced spore germination and subsequent de novo activity of an enzyme capable of producing a germinant in the presence of the germinogenic source and detecting the presence of a germination-derived product. The germinant which is formed promotes further spore germination with concomitant additional de novo enzyme synthesis or activation which results in a propagating cascade of analyte-independent germination after which a germination-derived product can be easily detected. The technique is particularly efficient to conduct thousands of parallel assays in an array of microscopic wells.
    Type: Grant
    Filed: November 16, 1999
    Date of Patent: July 22, 2003
    Inventor: M. Boris Rotman
  • Patent number: 6544383
    Abstract: The removal of inks from a pulp fiber slurry is accomplished by use of a combination of (1) a polyester obtained through reaction between di and/or tricarboxylic acids and/or anhydrides thereof and a polyalkylene glycol or one or more alkylene oxides, (2) a first deinking agent which is an alkoxylated hydrophobic base, e.g. an alcohol, amine, acid, dimer acid, salts thereof, or the like, and (3) a second deinking agent which is a second alkoxylated hydrophobic base having a cloud point about 2 to 20° lower than the cloud point of the first deinking agent. Use of the three component combination allows an improved foam profile allowing longer continuous operation or one or more of a reduction in total chemical demand, optical bleach demand, and stickies.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: April 8, 2003
    Assignee: KAO Specialties Americas
    Inventors: Peter Robinson, Hugh Lavery
  • Patent number: 6071888
    Abstract: The present invention is directed to compositions containing beta-alanine which are useful for treating cancer. The composition preferably comprises a ribose compound, L-beta-alanine, ascorbic acid, and nicotinic acid. The present invention is particularly directed to a composition useful for treating melanoma, and a method for treating melanoma with the composition.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: June 6, 2000
    Assignee: Aliatros Medical, a.s.
    Inventors: Blanka Rihova, Yveta Germano, Olga Kufudaki, deceased
  • Patent number: 5951719
    Abstract: An improved method for fixing color of a dyed textile fabric by coating a dyed textile with an acrylamide polymer which has been reacted with glyoxal at a mole ratio of glyoxal to polymer of at least 0.8:1. Preferably the dyed textile fabric has been pre-coated with an anionic polymer.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: September 14, 1999
    Assignee: Callaway Corporation
    Inventors: Anthony Cooper, Richard T. Underwood, Geoffrey Monteith, Michael Wright
  • Patent number: 5929214
    Abstract: Porous polymer monoliths are made thermally responsive by functionalizing/grafting the pores with thermally responsive polymers and copolymers. Depending on the reaction conditions employed, the grafted polymer can either completely block flow through micrometer-sized pores in the monoliths or control the flow rate through the monoliths. The grafted monoliths are useful as thermal gates, thermal valves, and for isocratic hydrophobic interaction chromatography of proteins.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: July 27, 1999
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Eric C. Peters, Frantisek Svec, Jean M.J. Frechet
  • Patent number: 5783041
    Abstract: A method for imparting dry strength to paper by adding to a pulp slurry during a paper-making process a mixed resin solution containing (i) an aminopolyamide-epichlorohydrin resin and (ii) a glyoxylated acrylamide-dimethyl diallyl ammonium chloride resin, in combination with (iii) a high charge density cationic polymer.
    Type: Grant
    Filed: April 18, 1996
    Date of Patent: July 21, 1998
    Assignee: Callaway Corporation
    Inventor: Richard T. Underwood
  • Patent number: 5695639
    Abstract: A greatly simplified improved vacuum filter funnel consists of two pieces, namely an upper reservoir member and a lower spout member. The upper reservoir member has an annular ring downwardly extending from the bottom thereof which fits inside an annular rim upwardly extending from the top of the lower spout member. A filter disk rests on an integral grid at the top of the lower spout member and is held in place between the upper and lower members by solely the weight of the upper member. The filter disk is readily removed after simply lifting up the upper reservoir member. Both the reservoir and spout members are preferably constructed of a chemical and heat resistant organic plastic, for example polysulfone, so that the parts may be sterilized in an autoclave.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: December 9, 1997
    Assignee: Micron Separations, Inc.
    Inventor: James S. Johnson
  • Patent number: 5547121
    Abstract: The reliability of a braze joint formed between a diamond film and a tungsten carbide body is increased by use of a vanadium containing braze. The braze joint exhibits an average shear strength greater than about 40,000 pounds per square inch, (276 MPa) and the braze exhibits a contact angle with the diamond film of less than about
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: August 20, 1996
    Assignee: Saint-Gobain/Norton Industrial Ceramics Corp.
    Inventors: Rakesh R. Kapoor, Bela G. Nagy, Louis K. Bigelow
  • Patent number: 5480598
    Abstract: A nozzle assembly for forming hollow fibers, particularly a "Z-fiber" having longitudinally oriented trabeculae with the fiber wall, is provided. The nozzle assembly contains a replaceable nozzle cap, a replaceable seal-guide, and a retractable central bore used to supply core material for the hollow fibers. The Z-fibers are particularly useful in enabling cells, solutes, or the like, to enter the fiber wall and move longitudinally into the center of the fiber wall.
    Type: Grant
    Filed: September 17, 1992
    Date of Patent: January 2, 1996
    Assignee: Brown Univ. Research Foundation
    Inventors: Frank T. Gentile, Michael J. Lysaght, Nicholas F. Warner
  • Patent number: 5466646
    Abstract: A process for the preparation of solid state materials such as catalysts, electrolytes, piezo electric materials and superconductors is disclosed. The process produces materials with high phase purity. Novel solid state materials having high phase purity are also disclosed.
    Type: Grant
    Filed: August 18, 1992
    Date of Patent: November 14, 1995
    Assignee: Worcester Polytechnic Institute
    Inventor: William R. Moser
  • Patent number: 5448457
    Abstract: A flashlight having a means attached thereto for holding and thereby illuminating an item such as a small document.
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: September 5, 1995
    Inventor: Michael Adjeleian
  • Patent number: 5431807
    Abstract: A process for carrying out in a consecutive fashion different modes of chromatographic separation in a liquid chromatography column using a single separation medium is disclosed. Separation media for use in such multimodal separations are also disclosed.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: July 11, 1995
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Jean M. J. Frechet, Frantisek Svec, Vladimir Smigol
  • Patent number: 5430175
    Abstract: Caged carboxyl compounds in which a 2-alkoxy-5-nitrophenyl photosensitive group blocks a carboxyl function are disclosed. Preferably the compounds are neuroactive amino acids. The compounds are photolyzable by laser pulses at wavelengths above about nm within about 3 .mu.s and provide a product quantum yield of greater than about 0.2.
    Type: Grant
    Filed: November 30, 1993
    Date of Patent: July 4, 1995
    Assignee: Cornell Research Foundation, Inc.
    Inventors: George P. Hess, Barry K. Carpenter, Doraiswamy Ramesh, Raymond Wieboldt
  • Patent number: 5334310
    Abstract: A continuous liquid chromatographic column containing a separation medium in the form of a macroporous polymer plug is disclosed. The column possesses numerous advantages over conventional columns which are packed with beads or particles. The plug contains both small pores less than 200 nm in diameter and large pores greater than 600 nm in diameter.
    Type: Grant
    Filed: October 23, 1992
    Date of Patent: August 2, 1994
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Jean M. J. Frechet, Frantisek Svec
  • Patent number: 5096813
    Abstract: Packages which are subject to tampering while in a store or deterioration over time due to the presence of oxygen may be readily identified by placing therein a multi-component visual indicator system which is sensitive to the presence of oxygen. The system, which may be prepared aerobically and then placed into an anaerobic environment for use, is not effected by the presence of reducing agents found commonly in foods, drugs, and cosmetics.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: March 17, 1992
    Assignee: Massachusetts Institute of Technology
    Inventors: Kim C. Krumhar, Marcus Karel
  • Patent number: D400993
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: November 10, 1998
    Inventor: Michael Adjeleian