Patents Represented by Attorney Bruce Stein

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  • Process to prepare 11&bgr;, 17&agr;,21-trihydroxy-6&agr;-methylpregna-1,4-diene-3,20-dione 21-acetate
    Patent number: 6828120
    Abstract: The present invention is a novel process for the transformation of 17&agr;-hydroxy-6&agr;-methylpregn-4-ene-3,20-dione 17-acetate (I) to 11&bgr;,17&agr;,21-trihydroxy-6&agr;-methylpregna-1,4-diene-3,20-dione 21-acetate (VI)
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: December 7, 2004
    Assignee: Pharmacia and Upjohn Company
    Inventors: Bruce Allen Pearlman, Michael J. White, Ivan G. Gilbert
  • Container for linezolid intravenous solution
    Patent number: 6796975
    Abstract: The present invention is a container for an IV aqueous solution of a Gram-positive oxazolidinone agent, such as linezolid a the compound of formula: which comprises having the container-solution contact surface material be a polyolefin.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: September 28, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Sandra M. Sims, Phil Bryan Bowman, Daniel C. Wade, Shri C. Valvani
  • Conversion of bisnoralcohol to bisnoraldehyde
    Patent number: 6608220
    Abstract: The present invention is a process for the conversion of bisnoralcohol to bisnoraldehyde (II), which is a known intermediate in the synthesis of progesterone.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: August 19, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventor: Bradley D. Hewitt
  • Process to prepare (2S)-2-(dipropylamino)-6-ethoxy-2,3-dihydro-1H-indene-5-carboxamide
    Patent number: 6576769
    Abstract: The present invention is a process, including intermediates, to produce (2S)-2-dipropylamino)-6-ethoxy-2,3-dihydro-1H-indene-5-carboxamide which is a useful pharmaceutical agent.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: June 10, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Jiong Jack Chen, Arthur Glenn Romero, Styrbjorn Bystrom
  • Oxazolidinone tablet formulation
    Patent number: 6514529
    Abstract: The present invention provides a compressed tablet of an antibacterial oxazolidinone agent which provides high drug load and excellent bioavailability.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: February 4, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Ken Yamamoto, Homer Lin
  • Aminohydroxylation of olefins in the presence of acetamide
    Patent number: 6509491
    Abstract: The present invention is a process to prepare on of a phenylisoserine ester of the formula (II) &phgr;—CH(NH—CO—CH3)—CH(OH)—CO—O—R1 with reduced amount of diol by-product by the use of a compound of the formula R2—CO—NH2 where R2 is C1-C6 alkyl with the proviso that R2 is not tertiary.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: January 21, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventor: Peter Guillaume Marie Wuts
  • Process to produce oxazolidinones
    Patent number: 6492555
    Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2—CH2—C*H(OH)—CH2—NH—CO—RN  (VIIIA) and processes for production of pharmacologically useful oxazolidinones.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: December 10, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventor: Bruce Allen Pearlman
  • 1,2,3,4,5,6,-hexahydroazepino [4,5-b]indoles containing arylsulfones at the 9-position
    Patent number: 6468999
    Abstract: The present invention are substituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (X) and unsubstituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (XI) such as the compound of EXAMPLE 13 which are useful in treating depression, obesity and other CNS disorders.
    Type: Grant
    Filed: July 11, 2000
    Date of Patent: October 22, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Eric Jon Jacobsen, Susan Korynne Hendges
  • Process to prepare (2S)-2-(dipropylamino)-6-ethoxy-2, 3-dihydro-1H-indene-5-carboxamide
    Patent number: 6462234
    Abstract: The present invention is a process, including intermediates, to produce (2S)-2-dipropylamino)-6-ethoxy-2,3-dihydro-1H-indene-5-carboxamide which is a useful pharmaceutical agent.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: October 8, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Jiong Jack Chen, Arthur Glenn Romero, Styrbjorn Bystrom
  • Method of treating sexual disturbances
    Patent number: 6455564
    Abstract: The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually therapeutic amount is from about 0.2 thru 8 mg/person/dose and where the sexually mating amount is from about 0.003 thru 0.2 mg/kg/dose.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: September 24, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Martin Durham Meglasson, Robert B. McCall
  • Crystal forms of 1-[5-methanesulfonamidoindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine
    Patent number: 6452007
    Abstract: The present invention relates to two novel crystal forms of a known compound, 1-[5-Methanesulfonamidoindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl] piperazine monomethanesulfonate salt, which are useful for treating humans who are HIV positive, which are identified by a powder X-ray diffraction spectrum known commonly as the “S” and “T” forms.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: September 17, 2002
  • Linezolid-crystal form II
    Patent number: 6444813
    Abstract: The invention is a process to produce a compound, linezolid which is useful as an antibacterial agent.
    Type: Grant
    Filed: January 29, 2001
    Date of Patent: September 3, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventor: Michael S. Bergren
  • Process to produce oxazolidinones
    Patent number: 6410788
    Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2—CH2—C*H(OH)—CH2—NH—CO—RN  (VIIIA) and processes for production of pharmacologically useful oxazolidinones.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: June 25, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventor: Bruce Allen Pearlman
  • Process to prepare androst-4-en-17-carboxylic acid
    Patent number: 6410760
    Abstract: The process of the present invention transforms a steroidal ketone of formula (III) to androst-4-en-17&bgr;-carboxylic acid (IV) by reaction with K2SO5.KHSO4.K2SO4.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: June 25, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Kevin C. Grega, Scott W. Ashford
  • Phthalamide compounds
    Patent number: 6362334
    Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2—CH2—C*H(OH)—CH2—NH—CO—RN  (VIIIA) and processes for production of pharmacologically useful oxazolidinones.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: March 26, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventor: Bruce Allen Pearlman
  • Process to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]-quinolin-2(1h)-one
    Patent number: 6355802
    Abstract: The present invention is an improved prosess to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one the compound of formula (VII).
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: March 12, 2002
    Assignee: Pharmacia & Upjohn COmpany
    Inventor: Peter Guillaume Marie Wuts
  • Oxazolidinones to treat eye infections
    Patent number: 6337329
    Abstract: The present invention involves a method of treating an ophthalmic infection in a useful warm blooded mammal who is in need of such treatment which comprises topical administration of an ophthalmologically effective amount of an OXAZOLIDINONE.
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: January 8, 2002
    Assignee: Pharmacia & UpJohn Company
    Inventors: Robert J. Cochran, Charles W. Ford
  • Process to prepare taxol
    Patent number: 6307064
    Abstract: The present invention includes processes to prepare commercially important taxols (X) from substituted amino-3-phenyl (2R,3S) isoserinates (II). In addition processes to prepare the substituted amino-3-phenyl (2R,3S) isoserinates (II) as well as its precursor are set forth.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: October 23, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Peter G. M. Wuts, Robert C. Kelly
  • (R)-3-hydroxy-3-(2-phenylethyl)-hexanoic acid derivatives
    Patent number: 6265604
    Abstract: The compound of the present invention (R)-3-hydroxy-3-(2-phenylethyl)-hexanoic acid is an intermediate in the preparation of the anti-AIDS compound, [R-(R*,R*)]-N-[3-[1-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: July 24, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: James R. Gage, Robert Charles Kelly, Bradley D. Hewitt
  • Process to prepare cyclic-sulfur fluorine containing oxazolidinones
    Patent number: 6239283
    Abstract: The invention is a process for the preparation of cyclic-sulfur fluorine containing oxazolidinone antibacterial agents which utilizes the important tetrahydrothiopyran-o-fluorinated carbamate of formula (IV)
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: May 29, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventor: James R. Gage