Patents Represented by Law Firm Brumbaugh, Graves et al.
  • Patent number: 4952411
    Abstract: An inexpensive, easily available and convenient method of inhibiting the transmission of the AIDS virus in humans as a result of sexual intercourse is provided. The method relies upon a dual mode of action of antiviral compositions comprising silver salts, such as silver sulfadiazine, alone or in combination with chlorhexidine or sodium deoxycholate. These composition are effective to reduce the infectivity of the AIDS virus and also kill the causative organisms of many other sexually transmitted diseases (STD). The method of the invention is therefore useful to reduce the immediate risk of AIDS transmission. It also reduces future risk of AIDS transmission by eliminating STD causing organisms which increase the risk of AIDS.
    Type: Grant
    Filed: October 18, 1988
    Date of Patent: August 28, 1990
    Assignee: Trustees of Columbia University in the City of New York
    Inventors: Charles L. Fox, Jr., Shanta M. Modak
  • Patent number: 4946676
    Abstract: The invention relates to a new vaccine comprising a native protein capable of inducing the production of protective antibodies in a host, together with an adjuvant amount of certain proteins or peptides which, as such, are not capable of inducing substantial protective antibody titres but considerably enhance the immunizing activity of said native protein.The amino acid sequences of the adjuvant proteins and peptides show homology with the native proteins. Combination of inactivated picornavirus, such as poliovirus, with adjuvant amounts of denatured picornavirus, such as poliovirus, capsis proteins, in a vaccine, is highly advantageous.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: August 7, 1990
    Assignee: De Staat Der Nederlanden
    Inventors: Antonius L. Van Wezel, Antonius G. Hazendonk, Eduard C. Beuvery