Abstract: The present invention relates to a compound of formula (I):
wherein:
R3 is selected from the group consisting of 1-napthyl, 2-napthyl and cycloalkylphenyl; and
R4 and R5 taken together form a ring having from 5 to 10 carbon atoms.
Additionally, the invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal subject, such as a human, wherein increased angiogenesis is desired, comprising administering to a mammal in need of such therapy an effective amount of the aforementioned thiophene selective adenosine A1 allosteric enhancer.
Type:
Grant
Filed:
May 20, 2002
Date of Patent:
March 30, 2004
Inventors:
Joel M. Linden, Ray A. Ollson, Peter J. Scammells
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