Patents Represented by Attorney Burton Rodney

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  • Methods for the preparation of biphenyl isoxazole sulfonamides
    Patent number: 6515136
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: February 4, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Richard P. Polniaszek, Xuebao Wang, Jeffrey S. DePue, Chennagiri R. Pandit, Kumar G. Gadamasetti, Yadagiri Pendri, Eduardo J. Martinez
  • Potassium channel inhibitors and method
    Patent number: 6511977
    Abstract: Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure where A, B, D, Q, X1, R, R1, X2 and R2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: January 28, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: John Lloyd, Heather J. Finlay, Wayne Vaccaro, Karnail S. Atwal, Michael F. Gross, Kerry L. Spear
  • Combination of an ADP-receptor blocking antiplatelet drug and a thromboxane A2 receptor antagonist and a method for inhibiting thrombus formation employing such combination
    Patent number: 6509348
    Abstract: A method is provided for inhibiting platelet aggregation and thrombus formation by administering to a patient an ADP-receptor blocking antiplatelet drug, such as clopidogrel, in combination with a thromboxane A2 receptor antagonist, such as ifetroban, and optionally a cholesterol lowering drug, such as an HMG CoA reductase inhibitor, for example, pravastatin.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: January 21, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventor: Martin L. Ogletree
  • Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors
    Patent number: 6509330
    Abstract: Hydroxamic acids are provided which are ACE and/or NEP inhibitors and have the structure wherein R*, R and R1 are as defined herein and A is a dipeptide preferably derived from an amino acid, or is a conformationally restricted dipeptide mimic.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: January 21, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventor: Jeffrey A. Robl
  • Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
    Patent number: 6472414
    Abstract: Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2; Rx is H, alkyl, aryl or halogen; A is (1) a bond; (2) —O—; or (3) B is: and wherein L2, L1, R1, R2, R3, R3′, R3a, R3b, R4, R4′, R5, X,  are as defined herein.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: October 29, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, William A. Slusarchyk, Richard B. Sulsky, Joseph A. Tino
  • Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile
    Patent number: 6472427
    Abstract: The (R)-enantiomer of 4-[[(cyanoimino)[(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile as well as the corresponding (S)-enantiomer are useful for promoting hair growth such as in male pattern baldness.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: October 29, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventor: Karnail S. Atwal
  • Method of inhibiting or treating chemotherapy-induced hair loss
    Patent number: 6458835
    Abstract: A method for inhibiting hair loss and/or promoting hair growth in chemotherapy and/or radiation therapy patients wherein the (R)-enantiomer of 4-[[(cyanoimino)-[(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile is administered prior to, simultaneous with and/or after chemotherapy and/or radiation treatment.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: October 1, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventor: Karnail S. Atwal
  • 2-hydroxy-3—(4-hydroxy-3-sulfonamidophenyl)—propylamines useful as beta 3 adrenergic agonists
    Patent number: 6436914
    Abstract: Compounds are provided having the formula including pharmaceutically acceptable salts thereof, wherein R1 is lower alkyl, aryl or arylalkyl; A is hydrogen or B is hydrogen, alkyl, alkenyl, or but when A is hydrogen, B may only be R2, R2′, R2″, R3 R3′ and R3″ are as defined herein; m is 0−3. These compounds possess activity at the beta 3 adrenergic receptor in mammals and are useful in the treatment of diabetes, obesity, depression, achalasia and intestinal hypermotility disorders.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: August 20, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Philip M. Sher, William N. Washburn, Jollie D. Godfrey, Jr.
  • Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
    Patent number: 6414002
    Abstract: Compounds are provided which have the structure wherein Q is C or N, A is 0 or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: July 2, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter T. Cheng, Pratik Devasthale, Yoon Jeon, Sean Chen, Hao Zhang
  • Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
    Patent number: 6395767
    Abstract: Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula where x is 0 or 1 and y is 0 or 1 (provided that x=1 when y=0 and x=0 when y=1); n is 0 or 1; X is H or CN; and wherein R1, R2, R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, and other diseases as set out herein, employing such DP 4 inhibitor *or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity agent and/or other therapeutic agent.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: May 28, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jeffrey A. Robl, Richard B. Sulsky, David J. Augeri, David R. Magnin, Lawrence G. Hamann, David A. Betebenner
  • Benzoazepines and analogs thereof useful as growth hormone secretagogues
    Patent number: 6380184
    Abstract: Benzoazepines of the following formula wherein R1, R1a, R2, R9k, L, Q, X, Y and Z are as described herein, and analogs thereof are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: April 30, 2002
    Assignee: Bristol-Myers Squibb Co.
    Inventor: James J. Li
  • Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
    Patent number: 6369103
    Abstract: A method is provided for preventing or reducing the risk of onset of a cardiovascular event by administering an HMG CoA reductase inhibitor such as pravastatin, to a patient which has one or more risk factors for a coronary and/or cerebrovascular event such as hypercholesterolemia.
    Type: Grant
    Filed: January 18, 1994
    Date of Patent: April 9, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Bruce D. Behounek, Mark E. McGovern, Adeoye Y. Olukotun
  • Lactam compounds and their use as inhibitors of serine proteases and method
    Patent number: 6344450
    Abstract: Lactam inhibitors are provided which have the structure X is wherein Y is O or S and R4 is  R7O— or R8 and R1, R2, R3, R5, R6, R7, and R8, are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants, and are inhibitors of tryptase and thus are useful in treating asthma. Methods for treating cardiovascular diseases associated with thromboses and for treating asthma and related diseases are also provided.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: February 5, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory S. Bisacchi, Steven M. Seiler, R. Michael Lawrence, James C. Sutton, Jr., William A. Slusarchyk, Guohua Zhao
  • Lactam inhibitors of FXa and method
    Patent number: 6297233
    Abstract: Caprolactam inhibitors are provided which have the structure including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrugs thereof, wherein n is 1 to 5; and and Y R1, R2, R3, R5, R5a, R6, R7, R8, R9 and R10 are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants. A method for treating cardiovascular diseases associated with thromboses is also provided.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: October 2, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Philip D. Stein, Gregory S. Bisacchi, Yan Shi, Stephen P. O'Connor, Chi Li
  • Heterocyclic inhibitors of microsomal triglyceride transfer protein and method
    Patent number: 6281228
    Abstract: Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure including pharmaceutically acceptable salts thereof, or prodrug esters thereof, A is where Z is N or CH, or where Z is  or CH2 when is a single bond; and wherein L1, R, R1, R3, R3′, R3a, R3b, R4, R4′, R5, R5a, X,  are as defined herein.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: August 28, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventor: Joseph A. Tino
  • Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile
    Patent number: 6262122
    Abstract: The (R)-enantiomer of 4-[[(cyanoimino)-[(1,2,2-trimethylpropyl)amino]methyl]amino]-benzonitrile as well as the corresponding (S)-enantiomer are useful for promoting hair growth such as in male pattern baldness.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: July 17, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Karnail S. Atwal, Joyce Chou, Seshadri Neervannan
  • Combination of an ADP-receptor blocking antiplatelet drug and antihypertensive drug and a method for preventing a cerebral infarction employing such combination
    Patent number: 6248729
    Abstract: A method is provided for preventing a cerebral infarction by administering to a patient a combination of an ADP-receptor blocking antiplatelet drug, such as clopidogrel, in combination with an antihypertensive agent such as an angiotensin AII antagonist (for example, irbesartan), an ACE inhibitor (for example, fosinopril) or a NEP/ACE inhibitor such as omapatrilat.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: June 19, 2001
    Assignees: Bristol-Myers Squibb Co., Sanofi-Synthelabo
    Inventors: Anthony A. Coniglio, Francis R. Plat, Melvin S. Blumenthal
  • Method for treating schizophrenia employing an ace inhibitor
    Patent number: 6187752
    Abstract: A method is provided for treating schizophrenia in a mammalian species by administering an ACE inhibitor, such as captopril, alone or with a neuroleptic such as cholecystokinin, fluphenazine or haloperidol.
    Type: Grant
    Filed: September 12, 1991
    Date of Patent: February 13, 2001
    Assignee: E.R. Squibb & Sons, Inc.
    Inventors: Abraham Sudilovsky, Joram Feldon, Ina Weiner, A. David Smith, John N. P. Rawlins
  • Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines
    Patent number: 6160134
    Abstract: A process is provided for preparing chiral cyclopropane carboxylic acids, preferably of the structure ##STR1## which are intermediates used in preparing acyl guanidine sodium/proton exchange (NHE) inhibitors.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: December 12, 2000
    Assignee: Bristol-Myers Squibb co.
    Inventors: Bang-Chi Chen, Joseph E. Sundeen, Jeffrey T. North, Annie J. Pullockaran, Saleem Ahmad, Shung C. Wu, Karnail S. Atwal, Sundeep Dugar
  • Potassium channel inhibitors and method
    Patent number: 6150356
    Abstract: Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1## where A, B, D, Q, X.sup.1, R, R.sup.1, X.sup.2 and R.sup.2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: November 21, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: John Lloyd, Heather J. Finlay, Wayne Vaccaro, Karnail S. Atwal, Michael F. Gross, Kerry L. Spear