Abstract: This invention provides coded aperture imaging apparatus and methods for the detection and imaging of radiation which results from nuclear interrogation of a target object. The apparatus includes: 1) a radiation detector for detecting at least a portion of the radiation emitted by the object in response to nuclear excitation and for producing detection signals responsive to the radiation; 2) a coded aperture disposed between the detector and the object such that emitted radiation is detected by the detector after passage through the coded aperture; and 3) a data processor for characterizing the object based upon the detection signals from the detector and upon the configuration of the coded aperture.