Abstract: A compact unitary heat exchanger and debubbler for a liquid includes an elongated heat exchange element having an inverted V-shape and a vertically-extending debubbling chamber located between the legs of the inverted V. The heat exchange element is made up of an inner tube surrounded by an outer tube, so that a heat exchange fluid such as water flowing within the inner tube exchanges heat with a treated liquid flowing within a space defined between the inner and outer tubes. After passing through the heat exchange element the treated liquid passes through the debubbling chamber and then through the device outlet. A bypass passageway in the vicinity of the treated liquid inlet to the device connects the debubbling chamber with the space between the inner and outer tubes of the heat exchange element. A valve movable into open and closed positions is provided in this bypass passageway.

Abstract: A unitary device for the treatment and collection of blood from two different sources during a surgical procedure comprises a hollow housing made of a rigid, preferably transparent, material, first and second blood inlets in the housing, a first blood treatment element inside the housing comprising a layer of porous defoaming material and a layer of non-woven depth filter material, and a second blood treatment element inside the housing comprising a layer of porous defoaming material and free of any depth filter material. The novel device also includes internal walls for providing two blood flow paths therein, one through the first inlet, the first blood treatment element, a blood collection reservoir defined within the device and a treated blood outlet in the bottom wall of the housing, and the other through the second inlet, the second blood treatment element, the blood collection reservoir and the blood outlet.

Abstract: A process for preparing halomethyl esters of penicillanic acid sulfone, intermediates to beta-lactamase inhibitors, from the corresponding substituted thiomethyl and sulfinylmethyl esters and a halogenating agent. The thiomethyl and sulfinylmethyl esters of penicillanic acid sulfone are useful intermediates.

Abstract: A novel process is described for preparation of biotin comprising preparation of substituted 3H, 5H-imidazo[1, 5c]tetrahydro thiazoles by contacting the boron trifluoride adduct of an appropriate thiazoline with the metallic derivative of an ester enolate, reducing the ester, hydrolyzing the thiazolidine moiety and hydrolyzing or oxidizing the resultant compound. Intermediates obtained in the preparation of biotin by the above process and alternate procedures for preparing said intermediates are also presented. A novel process for preparation of d-biotin is also given.

Abstract: The novel N,N-bis(higher-n-alkyl)aminomethylphenylethanolamines and their mineral acid and organic acid salts are useful for preventing viral infections in mammals and also for stimulating cellular mediated immune response.

Abstract: Preparations useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The preparations contain substituted and unsubstituted coumarin-4-carboxylic or acetic acid derivatives as the active ingredients.

Abstract: Novel spiro-polycyclicimidazolidinedione derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The derivatives include 2',3'-dihydro-spiro[imidazolidine-4,4'-[4'H]-naphtho[1,2-b]pyran]-2,5-dion e, 2',3'-dihydro-spiro-[imidazolidine-4, 4'-[4'H]-naphtho[1,2-b]thiopyran]-2,5-dione, 1',2',3',4'-tetrahydro-spiro[imidazolidine-4,1'-benz[a]anthracene]2,5-dion e, 2',3'-dihydro-spiro[imidazolidine-4,1'phenalene]-2,5-dione, 1',2',3',4'-tetrahydro-spiro[imidazolidine-4,1'-phenanthrene]-2,5-dione, the 2,1 isomers of the 2',3'-dihydro-4'H-pyran and 2',3'-dihydro-4'H-thiopyran derivatives, the 2',3'-dihydro-4'H-anthracenopyran and 2',3'-dihydro-4'H-anthracenothiopyran derivatives, the spiro-4,4' isomer of the tetrahydrophenanthrene derivative, the [b] isomer of the benzanthracene derivative and the mono or disubstituted 2',3'-dihydro-4'H-naphthopyran, 2',3'-dihydro-4'H-naphthothiopyran and tetrahydrophenanthrene derivatives.

Abstract: Novel phenyl or phenoxy substituted spiro-imidazolidinedione derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The derivatives include the phenyl or phenoxy substituted spiro-imidazolidine naphthalene, chroman, thiochroman sulfoxychroman, sulfonochroman dione compounds and the substituted forms thereof.

Abstract: Novel spiro-furanohydantoin derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The compounds include 2-methyl-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione, 2-fluoro-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione, 2-chloro-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione, 2-bromo-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione and spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione.