Abstract: A fastener for securely attaching a board perpendicularly to an edge of a composite board that includes a first portion and a second portion. The first portion includes a dowel that fixedly engages in a blindbore in the edge of the composite board, a washer that removably abuts against the dowel and the edge of the composite board and limits travel of the dowel in the blindbore, glue that is disposed on the dowel and in the blindbore and fixedly engages the dowel in the blindbore, and an installation screw that extends through the washer and threadably into the dowel, and when tightened, holds the first portion together as a unit, while the unit is being installed in the blindbore, and once the unit is installed, the installation screw and the washer are removed, with the glue maintaining the first portion in the blindbore.
Abstract: A preparation for and method of treating PFB. The preparation is a topical solution comprising a mixture of alophatic alcohol, liquid aloe, liquid camphor, and the soluble materials of the fresh fig leaves of Ficus Carica.
Abstract: Low solubility drug coated bead compositions, capsules filled therewith and method of preparation thereof, especially wherein the low solubility drug is an antiandrogenic steroid and most especially wherein the antiandrogenic steroid is (5.alpha.,17.alpha.)-1'-(methylsulfonyl)- 1'-H-pregn-20-yno[3,2-c]pyrazol-17-ol, are disclosed.
Abstract: Soft capsules coated with an enteric coating comprising a 1:1 copolymer of methacrylic acid and methyl or ethyl acrylate or methyl or ethyl methacrylate and a plasticizer without need for a subcoating and optionally additionally coated with a protective coating comprising hydroxypropyl methylcellulose or hydroxypropyl cellulose or a mixture thereof and a plasticizer and method of preparation thereof are disclosed.
Abstract: Extrudable elastic oral pharmaceutical gel compositions, especially containing aetaminophen as the therapeutically active agent, and manually operable metered dose dispensers containing them and method of making and method of use thereof are disclosed.
Abstract: Novel 2-substituted saccharins which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula ##STR1## wherein: L is --O--, --S--, --SO-- or --SO.sub.2 --;m and n are each independently 0 or 1;R.sub.1 is halo, lower-alkanoyl, 1-oxophenalenyl, phenyl or substituted phenyl, heterocyclyl or substituted heterocyclyl or, when L is --O-- and n is 1, cycloheptatrienon-2-yl or, when L is --S-- and n is 1, cyano or lower-alkoxythiocarbonyl or, when L is --SO.sub.2 -- and n is 1, lower-alkyl or trifluoromethyl;R.sub.2 is hydrogen, lower-alkoxycarbonyl, phenyl or phenylthio; andR.sub.3 and R.sub.4 are each hydrogen or various substituents and processes for preparation and pharmaceutical compositions and method of use thereof are disclosed.
Type:
Grant
Filed:
November 15, 1991
Date of Patent:
August 17, 1993
Assignee:
Sterling Winthrop Inc.
Inventors:
Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Dennis J. Hlasta, Ranjit C. Desai, Chakrapani Subramanyam, Lee H. Latimer, Eric P. Lodge
Abstract: Low solubility drug coated bead compositions, capsules filled therewith and method of preparation thereof, especially wherein the low solubility drug is an antiandrogenic steroid and most especially wherein the antiandrogenic steroid is (5.alpha.,17.alpha.)1'-(methylsulfonyl)-1'H-pregn-20-yno[3,2-c]pyrazol-17- ol, are disclosed.
Abstract: Sugar or sugar/starch beads coated with a first coating of a drug, for example 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(4-pyridinyl)-nicotinonitrile (milrinone), hydroxypropyl methylcellulose or hydroxypropyl cellulose and a plasticizer selected from triacetin, diacetylated monoglycerides, glycerin, propylene glycol, polyethylene glycol, diethyl phthalate and triethyl citrate or a mixture of two or more thereof and a second coating of high-viscosity ethylcellulose, low-viscosity ethylcellulose, hydroxypropyl cellulose, polyvinyl acetate phthalate and a plasticizer selected from diacetylated monoglycerides and triacetin or a mixture thereof and optionally coated with additional first coating and capsules filled therewith and method of preparation thereof are disclosed.
Type:
Grant
Filed:
September 13, 1991
Date of Patent:
May 25, 1993
Assignee:
Sterling Drug Inc.
Inventors:
Steven E. Frisbee, Gregg Stetsko, Margaret A. Lawton
Abstract: Selenomerocyanines, for example the compound having the structural formula ##STR1## a process for preparation thereof, methods of use thereof as photosensitizers for generation of singlet oxygen, virus inactivation and cancer cell inactivation, and photosensitized silver halide photographic emulsions containing them are disclosed.
Abstract: The method of use of a combination of the antiandrogen (5.alpha.,17.alpha.)-1'-(methylsulfonyl)-1'H-pregn-20-yno[3,2-c]pyrazol-17 -ol (Win 49596) and the 5.alpha.-reductase inhibitor (5.alpha.,17.beta.)-N-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carb oxamide (finasteride) for treating prostate disease in a male mammal and pharmaceutical compositions thereof are disclosed.
Abstract: 2'-Alkylsulfonylsteroido[2,3-d]oxazoles, for example 2'-methylsulfonyl-5.alpha.-pregn-2-en-20-yno[2,3-d]oxazol-17.beta.-ol, which are useful as antiandrogenic agents, and proceses for preparation, method of use and compositions thereof are disclosed.
Abstract: 5'-Alkylsulfonylsteroido[3,2-b]furans, for example 5'-methylsulfonyl-5.alpha.-pregn-2-en-20-yno[3,2-b]furan-17.beta.-ol having the structural formula, ##STR1## which are useful as antiandrogenic agents, and processes for preparation, method of use and compositions thereof are disclosed.
Type:
Grant
Filed:
June 21, 1990
Date of Patent:
March 31, 1992
Assignee:
Sterling Drug Inc.
Inventors:
Robert G. Christiansen, Malcolm R. Bell, Virendra Kumar
Abstract: Antiglaucoma compositions containing 3-R.sub.3 -4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles and a method of use thereof in the treatment of glaucoma.
Abstract: A merocyanine dye having the formula: ##STR1## wherein: R.sup.1 and R.sup.2 independently are H, alkyl, alkoxy, or aryl, andR.sup.7 and R.sup.8 may each be H with the proviso that a pair of R's selected from the pairs R.sup.1 and R.sup.2, R.sup.1 and R.sup.7, and R.sup.2 and R.sup.8 can together comprise the atoms necessary to form a fused aromatic ring on the benzene radical to which they are attached and only one of R.sup.1 and R.sup.2 can be H;R.sup.5 and R.sup.6 comprise alkyl of from 1-18 carbon atoms provided that the sum of the carbon atoms in R.sup.5 and R.sup.6 is at least 8;R.sub.9 is an alkylene group of 2-9 nuclear carbon and hetero atoms; andZ.sup.+ is a cation.This dye is useful in a method for inactivating viruses comprising contacting the viruses with the compound and exposing the resulting mixture to visible light to excite and inactivate the viruses. The compounds are also useful in the irradiation-induced inactivation of leukemia cells.
Type:
Grant
Filed:
February 26, 1990
Date of Patent:
October 1, 1991
Assignee:
Eastman Kodak Company
Inventors:
Wolfgang H. Gunther, Frederick J. Sauter
Abstract: 2'-Alkylsulfonylsteroido[3,2-d]thiazoles, for example 2'-methylsulfonyl-5.alpha.-pregn-2-en-20-yno[3,2-d]thiazol-17.beta.-ol, which are useful as antiandrogenic agents, and processes for preparation, method of use and compositions thereof are disclosed.