Patents Represented by Attorney C. S. Quagliato

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  • Oxidization metabolites of 5-.alpha.-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione
    Patent number: 5324734
    Abstract: The compounds of formula (I) ##STR1## wherein R is selected from the group hydroxymethyl and carboxy, have been identified as metabolites of 5.alpha.-23-methyl-4-aza-21-nor-chol-1-ene-3,20-dione and are believed to be active as testosterone 5.alpha.-reductase inhibitors and would thus be useful for treatment of acne, seborrhea, female hirsutism or benign prostatic hypertrophy.
    Type: Grant
    Filed: September 15, 1992
    Date of Patent: June 28, 1994
    Assignee: Merck & Co., Inc.
    Inventors: John D. Gilbert, Timothy V. Olah