Abstract: An in-focus image of an information-bearing region within and/or on a substance is discriminated from an out-of-focus image so as to reduce errors in image information of the substance by producing a probe beam and a reference beam from a wideband point source, producing antisymmetric spatial properties in the reference beam, converting the probe beam to a beam focused to a line in the region, producing an in-focus return probe beam, and producing antisymmetric spatial properties in the in-focus return probe beam. Then the in-focus return probe beam is spatially filtered and focused to a line image in a detector plane of a detector system. The reference beam is spatially filtered and focus to a line image in the detector plane. A beam from an out-of focus image point is spatially filtered. The line image of the spatially filtered reference beam is interfered with the spatially filtered beam from the out-of-focus image point and the line image of the spatially filtered in-focus return probe beam.