Abstract: A composition comprising an ethylene vinyl alcohol copolymer and a dimethyl acetamide solvent is provided for forming a coating on prostheses such as stents. The composition can include an active agent or therapeutic substance. Methods are also provided for coating the stents.
Type:
Grant
Filed:
April 27, 2001
Date of Patent:
November 16, 2004
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Yung-Ming Chen, Syed F. A. Hossainy, Deborra Sanders Millare, Wouter E. Roorda, Ashok A. Shah
Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
Type:
Grant
Filed:
December 28, 2000
Date of Patent:
September 14, 2004
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
Abstract: An ethylene vinyl alcohol coating for an implantable device or prosthesis, such as a stent, is provided. Compositions are also provided for coating the implantable device. The compositions can include an ethylene vinyl alcohol copolymer added to an iso-propyl alcohol (IPA)/water solvent. Active agents, such as actinomycin D, can be included in the composition to be carried by the copolymer matrix.
Type:
Grant
Filed:
December 28, 2000
Date of Patent:
July 6, 2004
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Yung-Ming Chen, Ashok Shah, Vinayak D. Bhat, Syed F. A. Hossainy, Daryush Mirzaee, Evgenia Mandrusov, Deborra Sanders-Millare, Judy A. Guruwaiya
Abstract: A membrane that reduces the rate at which a therapeutic substance is released from an implantable medical device, such as a stent, is disclosed.
Abstract: A coating for a prosthesis, for example a stent, and a composition for forming the coating is disclosed. The coating can serve as a primer, allowing substances, such as polymers, to be effectively secured by the prosthesis. Alternatively, the coating can serve as a reservoir, allowing for the local and sustained release of a therapeutic substance to biological tissues. The composition can be formed from an ethylene vinyl alcohol copolymer and a dimethylsulfoxide solvent, with or without a therapeutic substance. Alternatively, the composition can be formed from an ethylene vinyl alcohol copolymer, a dimethylsulfoxide solvent, and a wetting fluid, with or without a therapeutic substance. The composition is applied to a surface of the prosthesis and essentially all of the dimethylsulfoxide solvent or dimethylsulfoxide solvent/wetting fluid is removed or allowed to evaporate to form the coating.
Type:
Grant
Filed:
December 23, 1999
Date of Patent:
March 30, 2004
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Syed F. A. Hossainy, Deborra Sanders-Millare, Judy A. Guruwaiya, Daniel A. Castro, Sameer Harish, Steven Z. Wu