Abstract: The invention provides a high affinity heme-binding agent, which can be provided in the form of a pharmaceutical composition that includes, optionally, a pharmaceutically acceptable carrier. The heme-binding agent can be used in a method of facilitating heme-iron export from a cell. The method comprises contacting a cell with a high affinity heme-binding agent. Also provided is a method of treating a disorder associated with excess iron in cells in a subject. The method comprises administering to the subject an effective amount of the composition of the invention. The subject is typically a mammal, most typically a human or veterinary subject.

Abstract: Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume flowing through a single channel.

Abstract: Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. Preferred immunogenic polypeptides include gp100, her2/neu ECD-PD, ICD and M. tuberculosis antigens. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.

Abstract: Double-layer capacitors capable of operating at extremely low temperatures (e.g., as low as ?75° C.) are disclosed. Electrolyte solutions combining a base solvent (e.g., acetonitrile) and a cosolvent are employed to lower the melting point of the base electrolyte. Example cosolvents include methyl formate, ethyl acetate, methyl acetate, propionitrile, butyronitrile, and 1,3-dioxolane. An optimized concentration (e.g., 0.10 M to 0.75 M) of salt, such as tetraethylammonium tetrafluoroborate, is dissolved into the electrolyte solution. In some cases (e.g., 1,3-dioxolane cosolvent) additives, such as 2% by volume triethylamine, may be included in the solvent mixture to prevent polymerization of the solution. Conventional device form factors and structural elements (e.g., porous carbon electrodes and a polyethylene separator) may be employed.

Abstract: The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

Abstract: A sensor device for monitoring and testing for potential corrosion of structural elements is disclosed. A membrane including a thin conductor sense loop within it may be disposed near a structural element to be monitored. Measured changes in the electrical properties of the conductor sense loop reveal corrosion of the conductor and can indicate potential corrosion in the structural element. The sensor may also be implemented as a gasket. Connection to the sensor device may be through a connector or using a wireless reader which remotely energizes the sensor device.

Abstract: Structural health monitoring apparatuses and methods are disclosed. One or more structural health sensors may be used to disconnect and/or connect one or more RFID chips to an antenna such that wireless communication with the one or more RFID chips (or the absence of wireless communication) through the antenna indicates the structural health status. Example structural health sensors may be moisture detecting or fracture detecting. A remote reader may be used to establish the wireless communication with the one or more RFID chips to determine the structural health. The sensors and RFID chips may be passive and powered through the wireless communication from the remote reader. Such apparatuses and methods may be applied to any large structures requiring regular inspection, such as aircraft, ships, automobiles or buildings.

Abstract: A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of the polypeptide, and altering the mechanical tension of the polymer, thereby altering the conformation of the polypeptide. The alteration of the conformation of the polypeptide may increase or decrease the binding affinity of the polypeptide for a substrate bound by the polypeptide, or alter the catalytic rate of an enzyme. Typically, the polymer is a polynucleotide or polypeptide.

Abstract: Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. The pharmaceutical compositions of the invention can be administered to a subject, thereby providing methods for inhibiting M. tuberculosis-infection, for inhibiting tumor growth, for inhibiting the development of a cancer, and for the treatment or prevention of infectious disease. The invention further provides a method for producing T cells directed against a tumor cell or a M. tuberculosis-infected cell, wherein a T cell is contacted with an APC that is modified to present an hsp110 or grp170 polypeptide and an immunogenic polypeptide associated with a tumor or with the M. tuberculosis-infected cell.

Abstract: The invention provides molecules that target cancer-specific transcription complexes (CSTC), compositions and kits comprising CSTC-targeting molecules, and methods of using CSTC-targeting molecules for the treatment) detection and monitoring of cancer.

Abstract: Apparatuses and methods for a ornamental piercing of body parts are disclosed. An exemplary a piercing instrument includes a post carrier disposed to translate in a first channel within the body piercing instrument, a nut carrier disposed to translate in second channel within the body piercing instrument in opposition to translation of the post carrier and a synchronizing mechanism between the post carrier and the nut carrier to coordinate opposing motion relative to the body piercing instrument of both the post carrier and the nut carrier simultaneously. The synchronizing mechanism can be a gear, where the post and nut carriers include racks that engage the gear. The body piercing instrument can be hand-operated and also include a stabilizing surface to support the body part to be pierced during operation.

Abstract: A structural phased array antenna and method for manufacturing are disclosed. An integrated structural antenna aperture can be used to reduce net weight, cost, and volume where an array of antenna elements are incorporated into a structural member, e.g. in a spacecraft. A structural material layer, such as a structural foam, may be used with the array of individual antenna element cavities machined into the layer. The antenna element cavities are lined with a conductive material, such as plated aluminum. Facesheets may be bonded to the front and/or backside of the structural material layer in order to increase strength and/or stiffness using an RF transparent material. The array of antenna elements may be coupled to filters at the back side of structural material layer.

Abstract: Systems and methods are disclosed for providing a federated backup involving the coordination and synchronization of backup and restore operations among a plurality of hosts to ensure data consistency. A master node (backup host) acts as the initiator, coordinator, controller, and possibly as primary console for the entire backup and restore operation. All other worker application hosts and/or worker backup hosts operate as worker nodes and perform various backup and restore steps as directed by the master node. Centralized error handling aborts or recovers the entire backup operation in the event of failure on any one node. In addition, a logical view of the data is provided such that the backup can be managed as one entity, while backing up the data of each node. The backup workload may also be distributed to any other dedicated worker backup hosts (nodes) in order to minimize the impact to the production environment.

Abstract: A universal adapter system and method for coupling payloads and launch vehicles are disclosed to provide optimum payload configurability. A modular bulkhead panel may be used that can support a plurality of payload platforms such that the layout of the plurality of payload platforms on the bulkhead panel can be altered without requiring structural redesign. A carbon composite honeycomb structural frame panel may be used. Multiple bulkhead panels can be stacked to handle larger payload weights. Hollow hexagonal keyways can be used to permit cable access to and from a missile deployment module. Hexagonal payload adapter platforms may be used to join the payload to the honeycomb bulkhead panel.

Abstract: Systems and methods are disclosed employing electric propulsion stationkeeping in a cyclical manner to better match the cyclical pattern of power generated by the solar array system. For a typical orbit design, e.g. a geostationary orbit, North-South stationkeeping can be intermittently suspended, tolerating some additional drift but yielding in a very significant reduction in the required solar power system. If necessary, stationkeeping can be supplemented with a chemical thrusters during off periods for the electric propulsion. Because of this, the overall electrical power margin for the solar array system design can be reduced without compromising the mission performance.

Abstract: A scalable, performance-based, volume allocation technique that can be applied in large storage controller collections is disclosed. A global resource tree of multiple nodes representing interconnected components of a storage system is analyzed to yield gap values for each node (e.g., a bottom-up estimation). The gap value for each node is an estimate of the amount in GB of the new workload that can be allocated in the subtree of that node without exceeding the performance and space bounds at any of the nodes in that subtree. The gap values of the global resource tree are further analyzed to generate an ordered allocation list of the volumes of the storage system (e.g., a top-down selection). The volumes may be applied to a storage workload in the order of the allocation list and the gap values and list are updated.

Abstract: A toroidal shaped or ring fuel tank located within the loft line of a blended wing body aircraft is disclosed. The ring tank may be used in an aircraft to store liquid hydrogen fuel with a reduced tank weight. The ring tank may be continuous with no tank end domes typically found on cylindrical pressure tanks, reducing tank weight for a given fuel volume. The ring tank configuration avoids increasing the aerodynamic shape of the aircraft and does not encroach on usable passenger or payload areas of the aircraft. In one example the ring tank may be configured in a nose down position such that the forward portion of the ring tank is outside the pressurized cabin area.

Abstract: The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method.

Abstract: Sensing motion of multiple degrees of freedom for an integral inertial measurement unit provided through the operation of a single centrally mounted planar disc resonator having a single driven mode in a single vacuum enclosure is disclosed. The resonator comprises a circumferentially slotted disc having multiple internal capacitive electrodes within the slots in order to excite a single in-plane driven vibration and sense in-plane vibration modes or motion of the resonator. In addition, vertical electrodes disposed below and/or above the resonator may also be used to sense out-of-plane vibration or motion. Acceleration sensing in three orthogonal axes can be obtained by sensing two lateral modes of the disc resonator in the plane of the disc from the internal electrodes and a vertical mode from the vertical electrodes.

Abstract: Techniques are disclosed for optimizing volume allocation on storage controllers that may have varying degrees of control over directing storage on ranks of pools attached storage components. A performance-based volume allocation algorithm can optimize allocation for such various controllers in a smooth, uniform manner allowing changes from one degree of control to another without incurring costly code changes and re-architecting costs. Where control is not available a surrogate set of possible ranks where the allocation could be made is developed and employed to calculate an adjusted utilization cost. In turn, the adjusted utilization cost is used to calculate a space limit value limited by a target performance threshold.