Abstract: A method and composition are disclosed utilizing the pure (R,R) isomer of formoterol, which is a potent bronchodilator with reduced adverse effects, having a low incidence of the development of tolerance and having increased duration of action.

Abstract: A cosmetic composition for skin care containing retinol and epidermal growth factor is disclosed. In embodiments of the cosmetic composition, the epidermal growth factor is preferably present in an amount of 0.00001 to 1% by weight, and more preferably 0.0001 to 0.1% by weight, based on the total weight of the composition. The EGF-containing cosmetic composition of the present invention enhances the skin care effect of retinol and also alleviates adverse effects of retinol, such as skin irritation.

Abstract: A method for loading and unloading of a solid substance having a high degree of water content from a cargo hold of a bulk carrier is disclosed. The degree of water content of the solid substance is such that a layer of liquid is formed above the solid substance. In accordance with the method, a predetermined volumetric ratio of solid substance and water is pumped out of the cargo hold by a pump that is seated on a float freely movable on the layer of liquid, at the same time as water is fed into the cargo hold at a volumetric rate substantially the same as the volumetric rate of water being pumped out.

Abstract: A pharmaceutical composition comprising decursin and its uses as a nephrotoxicity inhibitor, an antineoplastic agent, an antidiabetic agent, and as a cancer-cell differentiation induction agent are disclosed.

Abstract: Methods and compositions utilizing a compound represented by Formula III, wherein R is chosen from —OH, —P(O)(OH)2 and —SO3H, or pharmaceutically acceptable salts thereof, for the treatment of psychoses in humans are disclosed. The compounds of the present invention exhibit fewer side effects than risperidone, a lessened liability toward drug-drug interactions than risperidone and a more predictable dosing regimen than risperidone. The compounds of the invention are also useful for the treatment of emesis and withdrawal syndromes.

Abstract: An in-line biological liquid filtration system and method comprises a collection container for receiving biological liquid. A filter is located downstream of the collection container and in fluid flow communication therewith. A storage container for receiving filtered biological liquid is located downstream of the filter and the storage container is in fluid flow communication with the filter and with the collection container. An additive solution is located in the storage container. At least one automatic control member automatically restricts a flow of biological liquid or additive solution when flowing the liquid or solution between the collection container and the storage container.

Abstract: The present invention relates to a liquid suppository composition comprising diclofenac sodium, poloxamer and at least one polymer select from the group consisting of polyethylene oxide and polyvinylpyrrolidone. The composition provides the advantages of. (1) a feel of foreign matter or discomfort does not occur when the composition is rectally administered; and (2) administration is easy and after rectal administration, the composition is neither leaked out from the anus nor shifted into the end of large intestine.

Abstract: A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (S,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and to their use for the treatment of fungal infection are also disclosed.

Abstract: Compounds of Formula I are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds of Formula I, Y is an dialkoxyphosphonate, or &agr;-hydroxyamide group and Z is an acyl or &agr;-ketocarbamate functionality. Intermediates in the solid phase synthesis of compounds of Formula I, in which compounds are attached to a solid support, are also disclosed.

Abstract: A filtration system and method for the filtration of a biological liquid are disclosed. The system and method may include a biological liquid collection assembly, a filtration assembly in communication with the collection assembly and a blood components preservative assembly in communication with the collection assembly. The preservative assembly includes a blood components preservative container and the preservative container may contain a blood components preservative solution and contains a measured quantity of a sterile gas. The preservative assembly is adapted to automatically transfer at least a portion of, respectively, the preservative solution, if present, and the gas to the collection assembly under a force of gravity once fluid flow communication is commenced between the preservative container and the collection assembly.

Abstract: A method for preventing or reducing bacterial contamination of a viral vaccine is disclosed. The method comprises adding an effective preserving amount of a polybiguanide-containing preservative composition to a solution containing vaccine virus or virus antigen. The method is particularly useful in preventing or reducing bacterial contamination of process solutions involved in the manufacture of influenza vaccines.

Abstract: A process for making 2,7-dimethyl-2,4,6-octatrien-1,8-dial starting form an allylic halide is described. The process steps include aldehyde protection, conversion to a sulfide, oxidation to an allylic sulfone followed by a Ramberg-Backlund reaction and hydrolysis.

Abstract: An apparatus and method for illuminating a fluid having photosensitive material therein comprising a surface and a roller separated from the surface by a space. The space is adapted to receive a flexible container therein. The flexible container on the surface contacts the roller and the surface for translation through the space. A light source is adapted to transmit light to the space to illuminate the fluid and react with the photosensitive material as the flexible container translates through the space.

Abstract: The present invention relates to an assay apparatus for detecting a product in a sample. The assay apparatus comprises a fluid pathway with an input of the sample and an input for a reagent with a detectable moiety which transports the sample to a detecting means via a barrier arranged to prevent a product-reagent complex passage but allow passage of unbound reagent and sample. The apparatus also includes supply means for supplying a substance adapted to breakdown the complex into a detectable moiety which can flow through the barrier to the detecting means.

Abstract: A high capacity leukocyte depletion filtration media incorporates a high specific surface area components with a matrix of fibers, yielding a filtration medium that removes leukocytes by at least 99.99%. The filtration medium uses a significantly low weight ratio of high specific surface area components to the matrix of fibers. The high specific area creates a multitude of adhesion sites for leukocytes while the low weight ratios allow good filtration flow rates. The filtration medium is incorporated into a filter device for removing leukocytes from biological fluids.

Abstract: An in-line gravity filtration device for biological fluids such as blood or blood products is disclosed. The device includes a series of channels formed downstream of filtration elements. The channels are defined in cross sectional area by the distance between the filtration elements and their bottoms. The channels are configured to form flow paths to an outlet port so that air within the channels is forced downstream through the outlet port thereby minimizing air being trapped on the downstream side of the device. For optimum performance, the cross section area of a single continuous channel, or the sum of the cross sectional area of parallel channels, leading to a single outlet port, should not exceed the cross sectional area of the outlet port.