Abstract: A soft ionization device is disclosed that comprises a series of electrodes having spacing less than the means free path of the molecules to be ionized. In some embodiments, the soft ionization device is used in various applications that require ion or electron sources such as biological or chemical reactors, ion milling, and numerous replacements for conventional hot cathode systems. In another embodiment, a valence spectrometer is disclosed that is configured to variably ionize molecules by their valiancy. In other embodiments, the ionization device is coupled to a spectrometer for the characterization of biological matter. Also disclosed is a preconditioner for preparing biological matter to be ionized.

Abstract: Devices are disclosed that incorporate an ionization device for generating ions and electrons having first and second conductive electrodes that are separated by less than the mean-free-path of molecules being ionized. Electrons generated by the ionization device may be used for applications such as light sources, electron bombardment sensors, thyratrons, vacuum tubes, plasma displays, and microwave switches, and ions generated by the ionization device may be used, inter alia, in connection with ion focused milling devices, maskless ion implantation devices, ion beam lithography devices, semiconductor mask modification devices, and semiconductor chip wiring devices. Methods of use and manufacture are also provided.

Abstract: Various configurations of characterization systems such as ion mobility spectrometers and mass spectrometers are disclosed that are coupled to an ionization device. The ionization device is formed of a membrane that houses electrodes therein that are located closer to one another than the mean free path of the gas being ionized. Small voltages across the electrodes generate large electric fields which act to ionize substantially all molecules passing therethrough without fracture. Methods to manufacture the mass spectrometer and ion mobility spectrometer systems are also described.

Abstract: A technique is disclosed that is useful for determining the presence of specific hybridization expression within an output pattern generated from a digitized image of a biological sample applied to an arrayed platform. The output pattern includes signals associated with noise, and signals associated with the biological sample, some of which are degraded or obscured by noise. The output pattern is first segmented using tessellation. Signal processing, such as interferometry, or more specifically, resonance interferometry, and even more specifically quantum resonance interferometry or stochastic resonance interferometry, is then used to amplify signals associated with the biological sample within the segmented output pattern having an intensity lower than the intensity of signals associated with noise so that they may be clearly distinguished from background noise. The improved detection technique allows repeatable, rapid, reliable, and inexpensive measurements of arrayed platform output patterns.

Abstract: An automated internet based exchange system is described for controlling the exchanging of ownership interests in objects on a secondary market. The automated exchange includes one or more sub-exchanges for maintaining information representative of secondary market transactions and for controlling said transactions. The automated exchange includes a secondary portfolio auction sub-exchange, a pricing and valuation services sub-exchange, an electronic contract negotiation services sub-exchange and a delivery and auditing service sub-exchange. The automated exchange also includes a logic switch manager that creates opportunistic auctions from a transaction for a product or service so as to trigger further auctions or service sales on the same or different secondary markets.

Abstract: The method and system operate to calibrate a transmission laser of the dense wavelength division multiplexer (DWDM) and to lock the laser to a selected transmission wavelength. In one example, the transmission laser is a widely tunable laser (WTL) to be tuned to one of a set of International Telecommunications Union (ITU) transmission grid lines for transmission through an optic fiber. To lock the WTL to an ITU grid line, a portion of the output beam from the WTL is routed through the etalon to split the beam into a set of transmission lines for detection by a detector. Another portion of the beam is routed directly to another detector. A wavelength-locking controller compares signals from the two detectors and adjusts the temperature of the etalon to align the wavelength of one of the transmission lines of the etalon with the wavelength of the output beam, then controls the WTL in a feedback loop to lock the laser to the etalon line.

Abstract: A technique is described for quantitating biological indicators, such as viral load, using interferometric interactions such as quantum resonance interferometry. A biological sample is applied to an array information structure that has a plurality of elements that emit data indicative of viral load. A digitized output pattern of the arrayed information structure is interferometrically enhanced by generating interference between the output pattern and a reference wave. The interferometrically enhanced output pattern is then analyzed to identify emitted data indicative of viral load which in turn is used to determine viral load.

Abstract: The method and system operate to calibrate a transmission laser of the dense wavelength division multiplexer (DWDM) and to lock the laser to a selected transmission wavelength. In one example, the transmission laser is a widely tunable laser (WTL) to be tuned to one of a set of International Telecommunications Union (ITU) transmission grid lines for transmission through an optic fiber. To lock the WTL to an ITU grid line, a portion of the output beam from the WTL is routed through the etalon to split the beam into a set of transmission lines for detection by an etalon fringe detector. Another portion of the beam is routed directly to a laser wavelength detector. A wavelength-locking controller compares signals from the two detectors and adjusts the temperature of the etalon to align the wavelength of one of the transmission lines of the etalon with the wavelength of the output beam, then controls the WTL in a feedback loop to lock the laser to the etalon line.

Abstract: A semiconductor laser is provided having a cavity including a gain chip, a Mach-Zehnder wide tuning port, and a ring resonator mirror. Optical signals generated by the gain chip propagate through the Mach-Zehnder wide tuning port and into the ring resonator mirror where the optical signals are reflected back through the Mach-Zehnder wide tuning port to the gain chip. The ring resonator is configured to reflect only those optical signals back into the laser cavity having wavelengths within a set of sharp peaks and the laser cavity therefore can resonate only within one of the sharp peaks. The ring resonator mirror is heated to adjust its dimensions so as to maintain one of the sharp peaks at a selected emission wavelength. As optical signals reflected from the ring resonator pass through the Mach-Zehnder wide tuning port, the signals are split between two channels of differing lengths resulting in optical interference.

Abstract: The method and system operate to maintain a widely tunable laser (WTL) at a selected transmission wavelength. To lock the WTL to an ITU grid line, a portion of the output beam from the WTL is routed through the etalon to split the beam into a transmission line for detection by an etalon fringe detector. Another portion of the beam is routed directly to a laser wavelength detector to determine the power of the beam. A wavelength-locking controller compares signals from the two detectors and adjusts the temperature of the etalon to align the wavelength of one of the transmission lines of the etalon with the wavelength of the output beam, then controls the WTL in a feedback loop to lock the laser to the etalon line. The wavelength-locking controller thereafter monitors the temperature of the etalon and keeps the temperature constant to prevent any wavelength drift attributable to the etalon.

Abstract: A technique is disclosed that is useful for determining the presence of specific hybridization expression within an output pattern generated from a digitized image of a biological sample applied to an arrayed platform. The output pattern includes signals associated with noise, and signals associated with the biological sample, some of which are degraded or obscured by noise. Signal processing, such as interferometry, or more specifically, resonance interferometry, and even more specifically quantum resonance interferometry or stochastic resonance interferometry, is used to amplify signals associated with the biological sample having an intensity lower than the intensity of signals associated with noise so that they may be clearly distinguished from background noise. The improved detection technique allows rapid, reliable, and inexpensive measurements of arrayed platform output patterns.

Abstract: A system and method are disclosed for the detection of water vapor in a natural gas background. The system includes a light source operating in the 1.877-1.901 &mgr;m wavelength range passes through the natural gas to be detected by a detector. In one embodiment, the light source is a tunable diode laser and the moisture level is determined by harmonic spectroscopy.

Abstract: A field ionizing element formed of a membrane that houses electrodes therein that are located closer to one another than the mean free path of the gas being ionized. The membrane includes a supporting portion, and a non supporting portion where the ions are formed. The membrane may be used as the front end for a number of different applications including a mass spectrometer, a thruster, an ion mobility element, or an electrochemical device such as a fuel cell.

Abstract: The semiconductor laser has a resonance cavity composed of a gain chip, a Mach-Zehnder wide tuning port, and a wavelength-selective mirror component formed either as a ring resonator or a reflective Fabry-Perot etalon. Optical signals generated by the gain chip propagate through the wide tuning port and into the wavelength-selective mirror component and are then reflected back to the gain chip. The wavelength-selective mirror component is configured to reflect only those optical signals having wavelengths within a set of sharp peaks so that the laser cavity resonates only within the sharp peaks. The wavelength-selective mirror component is heated to adjust internal dimensions to maintain one of the sharp peaks at a selected emission wavelength. As optical signals pass through the wide tuning port, the signals are split between two channels of differing lengths resulting in optical interference.

Abstract: An interactive radio system is provided for use with broadcast radio stations wherein feedback is provided to subscribers of the system via the Internet. Interactive radio mobile units are mounted within vehicles or at other locations. Each mobile unit includes a receiver for receiving radio broadcasts, a GPS system for determining the location of the vehicle, and a wireless transmitter for transmitting interactive radio control signals to a network operation center. While listening to a radio broadcast, the subscriber selects program segments of interest by pressing an interactive radio control button on the mobile unit. The program segments are, for example, individual musical selections, advertisements or the like. In response, the mobile unit transmits the carrier frequency of the radio broadcast, the date and time, the geographical location of the vehicle, and a subscriber identification signal to the network operation center using the wireless transmitter.

Abstract: A total temperature probe with a complimentary sensor cavity for measuring multiple properties of a fluid flowing rapidly through the probe. The probe includes a sensor housing for diverting a portion of the rapidly flowing fluid into a primary flow path. A sample chamber within the probe houses a total temperature probe and is configured to divert a portion of the rapidly flowing fluid from a primary flowpath. An ancillary chamber adjacent to the sample chamber is configured to house an additional sensor and to divert a portion of the rapidly flowing fluid from the sample chamber. In some embodiments, the ancillary chamber diverts fluid directly from the rapidly flowing fluid. Preferably, the sensor housed within the ancillary chamber measures the water vapor level within the rapidly flowing fluid.

Abstract: The method and system operate to calibrate a transmission laser of the dense wavelength division multiplexer (DWDM) and to lock the laser to a selected transmission wavelength. In one example, the transmission laser is a widely tunable laser (WTL) to be tuned to one of a set of International Telecommunications Union (ITU) transmission grid lines for transmission through an optic fiber. To lock the WTL to an ITU grid line, a portion of the output beam from the WTL is routed through the etalon to split the beam into a set of transmission lines for detection by a detector. Another portion of the beam is routed directly to another detector. A wavelength-locking controller compares signals from the two detectors and adjusts the temperature of the etalon to align the wavelength of one of the transmission lines of the etalon with the wavelength of the output beam, then controls the WTL in a feedback loop to lock the laser to the etalon line.

Abstract: A soft ionization device is disclosed that comprises a series of electrodes having pacing less than the means free path of the molecules to be ionized. In some embodiments, the soft ionization device is used in various applications that require ion or electron sources such as biological or chemical reactors, ion milling, and numerous replacements for conventional hot cathode systems. In another embodiment, a valence spectrometer is disclosed that is configured to variably ionize molecules by their valiancy. In other embodiments, the ionization device is coupled to a spectrometer for the characterization of biological matter. Also disclosed is a preconditioner for preparing biological matter to be ionized.

Abstract: A technique is described for determining the effectiveness of medical therapy and dosage formulations by analyzing dot spectrograms representative of quantized hybridization activity in biological samples, such as DNA, RNA, or other protein biomolecular array samples, taken at different times from a patient undergoing the medical therapy. This technique enables disease progression analysis based on surrogate markers such as viral load. In accordance with the technique, a viral diffusion curve associated with a therapy of interest is generated and each dot spectrogram is then mapped to a viral diffusion curve using fractal filtering. Next, degree of convergence towards the peak of VDC, between the sample points on a filtered viral diffusion curve is determined. The technique allows for point-of-care viral load detection biosensors to accurately and reliably predict the likelihood of disease progression.