Patents Represented by Attorney Carl A. Randles, Jr.
  • Patent number: 4067874
    Abstract: Some new 4-amino-2-lower-alkyl-6-variable-pyridine-1-oxides are described. A new process is provided. The 6-variable is lower-alkyl, amino or substituted amino including saturated heterocyclic amino, e.g., pyrrolidinyl, piperidino, etc. The compounds are hypotensive agents and reduce blood pressure in animals.
    Type: Grant
    Filed: June 20, 1975
    Date of Patent: January 10, 1978
    Assignee: The Upjohn Company
    Inventor: Joseph J. Ursprung
  • Patent number: 4017630
    Abstract: Animals, especially birds and murine pests, are repelled by .gamma.- or .omega.-amino-.alpha.,.alpha.-diphenylalkanoamides, their acid addition and quaternary ammonium salts, their N-oxides, and acid addition salts of the N-oxides. The active agents can be coated on grains in order to repel animals especially birds. Animal pest damage to mature crops for harvest and newly planted seeds is prevented.
    Type: Grant
    Filed: November 29, 1974
    Date of Patent: April 12, 1977
    Assignee: The Upjohn Company
    Inventors: Alan J. Lemin, Paul W. O'Connell
  • Patent number: 3999975
    Abstract: A known compound, 2-ethyl-4-methyl diester of 3,5-dimethyl-2,4-pyrroledicarboxylic acid, has been found to be an excellent herbicide. A new method of controlling weeds and growth of plants with the compound is described along with herbicidal compositions.
    Type: Grant
    Filed: January 30, 1970
    Date of Patent: December 28, 1976
    Assignee: The Upjohn Company
    Inventor: Arnolds Steinhards
  • Patent number: 3998827
    Abstract: 6-Amino-1,2-dihydro-1-hydroxy-2-iminopyrimidines, their carboxyacylated counterparts, and the corresponding acid addition salts thereof are disclosed. These compounds, useful inter alia as antihypertensive agents, are substituted in the 4-position and optionally in the 5-position, the substituent in the 4-position being oxygen bearing secondary or tertiary amino moiety.
    Type: Grant
    Filed: February 27, 1975
    Date of Patent: December 21, 1976
    Assignee: The Upjohn Company
    Inventors: Richard C. Thomas, Jr., Harry Harpootlian
  • Patent number: 3932661
    Abstract: Certain benzoyl chloride phenylhydrazones have been found to be active against insects and mites, and they have also been found to be effective, broad-spectrum anthelmintics for suppressing parasitic worms in animals, particularly sheep. The benzoyl ring and the phenylhydrazone ring can be substituted with a halogen atom, a nitro group, or an alkyl group of from 1 to 6 carbon atoms, inclusive. A new class of pentahalobenzoyl chloride phenylhydrazones is described, particularly pentafluorobenzoyl chloride phenylhydrazones. The compounds are prepared by reacting a benzoic acid phenylhydrazide with phosphorus pentachloride to obtain a benzoyl chloride (dichlorophosphinyl)phenylhydrazone that is reacted with phenol to produce the desired benzoyl chloride phenylhydrazones. Certain of the compounds can be prepared by direct chlorination of a benzaldehyde phenylhydrazone. Methods of using the new compounds and new anthelmintic formulations are described.
    Type: Grant
    Filed: April 17, 1974
    Date of Patent: January 13, 1976
    Assignee: The Upjohn Company
    Inventor: Girts Kaugars
  • Patent number: 3931318
    Abstract: Certain new ar or ar' (alkylthio) benzoyl chloride phenylhydrazones have been found to be anthelmintics and active against arthropod pests. The benzoyl ring and the phenylhydrazone ring can be otherwise substituted with, for example, halogen atoms, nitro groups, .alpha.-fluoroalkyl groups, other alkylthio groups, and alkyl groups. The new compounds are prepared by reacting an ar or ar' (alkylthio) benzoic acid 2-phenylhydrazide with phosphorus pentachloride to obtain an ar or ar' (alkylthio) benzoyl chloride (dichlorophosphinyl)phenylhydrazone that is reacted with phenol to produce the desired ar or ar' (alkylthio) benzoyl chloride phenylhydrazones. Certain of the compounds can be prepared by direct halogenation of (alkylthio)benzaldehyde phenylhydrazone or an (alkylthio)benzoyl chloride phenylhydrazone. Methods of anti-arthropodal use and novel formulations for use are also described.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: January 6, 1976
    Assignee: The Upjohn Company
    Inventor: Girts Kaugars