Patents Represented by Attorney Carol A. Schneider

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  • Method for increasing the serum half-life of a biologically active molecule
    Patent number: 7022673
    Abstract: A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically active molecule. Also provided are polypeptide drugs having an increased serum half-life, e.g., human urokinase plasminogen activator (human “uPA” or “hUPA”) or a fragment or derivative thereof. Pharmaceutical compositions containing such molecules and methods of using them to treat uPA-mediated and uPA receptor-mediated disorders are also provided.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: April 4, 2006
    Assignee: Chiron Corporation
    Inventors: Robert J. Drummond, Steve Rosenberg