Abstract: It has now been found that at certain concentrations, sphingosylphosphorylcholine (SPC) in solution can be used for wound healing at concentrations of from 0.1 .mu.M to 500 .mu.M. It has been found that at concentrations of 2 .mu.M to 10 .mu.M very good results could be obtained. Compositions may be prepared using pharmaceutically acceptable carriers for topical application or for injection in or near the site of the wound.
Abstract: This invention provides a method of treating patients suffering from malaria whilst avoiding cardioarrhythmias, the improvement thereof comprising the administration of desbutylhalofantrine in place of halofantrine. Dosage of 500 mg every six hours for three doses on day one with repeat of that dosage on day 7 for a total dosage of 3000 mg is appropriate for most treatment purposes in adults. Desbutylhalofantrine may also be given at dosage of 50 to 1000 mg as a prophylactic measure. Dosage may be given daily or one day per week.
Type:
Grant
Filed:
August 23, 1996
Date of Patent:
January 27, 1998
Inventors:
Raymond Woosley, David L. Wesche, Brian G. Schuster
Abstract: Admisistration of sphingosine-1-phosphate to retard apoptosis in degenerative diseases as neurodegenerative disease, ischemic stroke and aging is disclosed wherein slowing of the process of programmed cell death is useful as a means to slow the degenerative process in patients suffering from these diseases.