Abstract: The compounds 8-bromo-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-c arboxylic acid and 8-chloro-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2- carboxylic acid are disclosed as potent antimicrobials. Pharmaceutically-acceptable carboxylate salts, acyl chlorides, esters and alkylaminoalkyl ester salts of the acids are also disclosed.

Abstract: An improved resin-coated fiberglass knit tape is disclosed which is highly extensible in the lengthwise direction and heat-set to alleviate fraying at cut ends. Heat-setting with essentially no tension on the tape accounts for retention of good extensibility. The invention is especially applicable to the field of orthopedic casting tape.

Abstract: The compounds 8-bromo-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quiniolizine-2- carboxylic acid and 8-chloro-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H,-benzo[ij]quinolizine-2 -carboxylic acid are disclosed as potent antimicrobials. Pharmaceutically-acceptable carboxylate salts, acyl chlorides, esters and alkylaminoalkyl ester salts of the acids are also disclosed.

Abstract: A disposable biomedical electrode is disclosed wherein the electrically-conductive material between the electrode plate and the skin comprises a swellable, conformable, cohesive, hydrophilic, electrically-conductive adhesive formed by an improved solventless process. The adhesive precursor comprises a polyhydric alcohol, a non-ionic unsaturated free radically polymerizable material, a free radical initiator, a crosslinking agent and an ionizable salt. The adhesive precursor is polymerized after coating onto the electrode plate or releasable transfer sheet, preferably by exposure to ultraviolet radiation.

Abstract: Improved, oil-in-water moisturizing compositions are disclosed comprising an oil phase containing at least one emollient oil and an oil-soluble acrylate polymer, a water phase and an emulsifying agent. The acrylate polymer improves the substantivity of the compositions.

Abstract: A biomedical electrode having a conductive adhesive thereon which is derived from an essentially solventless process. The resulting adhesive is characterized in that it is a swellable, dermally-nonirritating conformable, cohesive, ionic, hydrophilic polymer.

Abstract: A biomedical electrode having a conductive adhesive thereon which is derived from an essentially solventless process. The resulting adhesive is characterized in that it is a swellable, dermally-nonirritating conformable, coadhesive, ionic, hydrophilic polymer.

Abstract: The compounds 8-bromo-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quiniolizine-2- carboxylic acid and 8-chloro-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H,-benzo[ij]quinolizine-2 -carboxylic acid are disclosed as potent antimicrobials. Pharmaceutically-acceptable carboxylate salts, acyl chlorides, esters and alkylaminoalkyl ester salts of the acids are also disclosed.

Abstract: Radioactive seeds contained in a suture material are shielded during shipping and storage inside a curved tube of dense material having two open ends. The suture material protrudes through at least one end of the tube. Preferably, one end of the suture material has removable means for preventing the end from entering the tube prematurely, and the other end is attached to a needle.The seeds spaced from the open ends of the curved tube so as to prevent radiation from escaping from the tube.

Abstract: An orthopedic casting material is disclosed having improved strength and porosity characteristics. The casting material comprises a fabric which is made from a high modulus fiber and has a thickness between 0.020 and 0.045 inches and a mesh size of 20 to 200 openings per square inch. The fabric is impregnated with a reactive resin which hardens by wetting with a curing agent.

Abstract: A process is described for preparing adrenochrome comprising oxidizing adrenaline or a salt thereof with a persulfate in an aqueous medium at a pH in the range 4 to 8 in the presence of one or more water-soluble salts of bismuth.

Abstract: A wound dressing for wounds having a significant amount of exudate comprising a conformable, moisture vapor-permeable, liquid water-impermeable first layer containing at least one hole therein through which exudate can pass, and an imperforate, conformable, liquid water-permeable, moisture vapor-permeable second layer attached to the first layer and overlaying the hole or holes in the first layer and forming a reservoir into which the wound exudate can pass and from which the exudate can evaporate.

Abstract: A T.E.N.S. electrode is disclosed comprising an essentially dry, body-conformable, electrically-conductive interfacing layer having a maximum thickness of 10 mils, a low profile, one-piece electrically-conductive connector adherent to the top surface of the interfacing layer and a backing member, overlying the interfacing layer and the connector. The electrode is extensible in at least one direction up to 50 percent and requires less than about 25.times.10.sup.6 dynes/cm.sup.2 for an elongation of 20 percent as tested per ASTM Standard D-882.

Abstract: Topical therapeutic compositions are disclosed which contain from about 0.1 to 70 percent by weight of a water-soluble tertiary amine oxide and a therapeutic agent selected from the group consisting of erythromycin, benzoyl peroxide, hydrocortisone, tetracycline, 5-fluorouracil, and propranolol. The amine oxide enhances penetration of the therapeutic agent into and through the skin.

Abstract: Antimicrobial compounds of the following formula are disclosed: ##STR1## wherein Het is selected from the goup consisting of pyrryl, pyrrolidyl, tetrazolyl of the formula ##STR2## wherein R.sup.1 is lower alkyl or benzyl and oxadiazolyl of the formula ##STR3## wherein R.sup.2 is lower alkyl, trifluoromethyl or --NH.phi.--; X is hydrogen and when Het is pyrryl or pyrrolidyl, X may be fluorine. Pharmaceutically acceptable carboxylate salts and esters of the acids are also disclosed.

Abstract: This invention relates to antimicrobial compounds of the formula ##STR1## wherein X is hydrogen or fluorine; Y is selected from the group consisting of ##STR2## and ester, carboxylate salts, and alkylaminoalkyl ester salts thereof.

Abstract: Substituted 2-(trifluoroethoxy)benzamide, benzoic acid and benzoate compounds which are intermediates in the preparation of pharmaceutically active agents.

Abstract: The compounds 8-cyano-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid and 8-cyano-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-c arboxylic acid are disclosed as potent antimicrobial agents. Pharmaceutically-acceptable carboxylate salts, esters, acyl chlorides, amides and alkylaminoalkyl ester salts of the acids are also disclosed.

Abstract: A non-polarizable electrode is disclosed comprising a metallic sensing element in contact with an electrolyte gel or other conformable, electrically conductive skin-interfacing material containing dissolved electrolyte salt and an oxidizing agent. The oxidizing agent reduces the metal on the surface of the sensing element to a metal cation which reacts with the anion of the electrolyte salt to produce an insoluble compound which is deposited on the sensing element to render it non-polarizable. The preferred embodiment of the invention relates to silver/silver chloride electrodes.

Abstract: Improved conformable electrically-conductive compositions are disclosed comprising a soft, polar, polymeric binder; a plurality of soft, deformable, nonpolar microspheres; and an oleophilic electrically conductive filler. The compositions are particularly useful as the interface material between the skin and the electrode plate of a biomedical electrode.