Patents Represented by Attorney Carolyn D. Moon

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  • Process for the production of vinyl-GABA
    Patent number: 6090979
    Abstract: The present invention is directed to a method for producing vinyl GABA by submitting 5-vinylpyrrolidin-2-one to a basic hydrolysis.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: July 18, 2000
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Christian T. Goralski, John F. Hoops, Kuttanchery Ananthanarayanan Ramanarayanan
  • Esters of (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidi nemethanol
    Patent number: 6063793
    Abstract: The present invention is directed to esters of (+)-.alpha.-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT.sub.2A receptor and are useful in treating various conditions such as, for example, psychoses such as schizophrenia.
    Type: Grant
    Filed: June 22, 1999
    Date of Patent: May 16, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Albert A. Carr, Raymond W. Kosley, Jr., Luc Van Hijfte
  • Esters of (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
    Patent number: 6028083
    Abstract: The present invention is directed to esters of (+)-.alpha.-(2,3 Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT.sub.2A receptor and are useful in treating various conditions such as, for example, psychoses such as schizophrenia.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: February 22, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Albert A. Carr, Raymond W. Kosley, Jr., Luc Van Hijfte
  • Use of (+)-.alpha.-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl)ethyl]-4-piperidin emethanol in treating depressive disorders and bipolar disorders
    Patent number: 6022877
    Abstract: The present invention is directed to the use of (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol in treating Depressive Disorders and Bipolar Disorders.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: February 8, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventor: Cesare Mondadori
  • 4-piperidinyl) H-2-benzopyran derivatives useful as antipsychotic agents
    Patent number: 6004982
    Abstract: The present invention comprises (4-Piperidinyl)-1H-2-Benzopyran derivatives useful as antipsychotic agents, their intermediates, pharmaceutical compositions and methods of making these compounds. These compounds are useful in treating psychosis.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: December 21, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Joseph T. Stupczewski, Kenneth J. Bordeau, Shelley L. Pavlek
  • (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2- (4-fluorophenyl)ethyl]-4-piperidinemethanol
    Patent number: 6004980
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: December 21, 1999
    Assignee: Merrell Pharmaceuticals, Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay
  • Troponyl piperazines as dopamine D4 receptor ligands
    Patent number: 5998414
    Abstract: Described herein are compounds of the general formula: ##STR1## a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, wherein:R.sub.1 is H, halo, aryl or aryl substituted with one or two groups independently selected from halo, C.sub.1-4 alkyl, C.sub.1-4 -alkoxy, nitro, trifluoromethyl, trifluoromethoxy or cyano;R.sub.2 is C.sub.4-9 alkyl; phenyl or phenyl substituted with one or two groups selected independently from OH, cyano, halo, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, trifluoromethyl, trifluoromethoxy, nitro or phenyl; naphthyl;phenyl fused to a 5 or 6-membered heterocycle; the coumarin moiety ##STR2## wherein R.sub.3 and R.sub.4 are selected independently from H, C.sub.1-4 alkyl and C.sub.1-4 alkoxy;or 1,2-methylenedioxy phenyl;with the proviso that R.sub.2 is not phenyl or 3,4-dimethoxyphenyl when R.sub.1 is H.Also described is their use as pharmaceuticals to treat indications in which the D4 receptor is implicated, such as schizophrenia and anxiety.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: December 7, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Xin Wang, Jian-min Fu, Adi M. Treasurywala
  • (+) -.alpha.- (2,3-dimethoxyphenyl)-1-(2-(4-fluorephenyl) ethyl)-4-piepridinemethanol
    Patent number: 5874445
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: February 23, 1999
    Assignee: Merrell Pharmaceutical, Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
  • N-hydroxy-dibenz ?b,e!oxepinalkylamines, N-hydroxy-dibenz ?b,e!oxepinalkanoic acid amides and related heterocyclic analogues
    Patent number: 5840749
    Abstract: This invention relates to N-hydroxy-dibenz?b,e!oxepinalkylamines, N-hydroxy-dibenz?b,e!oxepinalkanoic acid amides and related heterocyclic analogues of the formula ##STR1## where X together with the carbon atoms to which it is attached forms a benzene or thiophene ring; W and Z are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; R.sup.1 is hydrogen, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; R.sup.2 is loweralkyl, cycloalkyl, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; m is 0 or 1 and n is an integer of 0 to 4 or the pharmaceutically acceptable salts thereof. The compounds of this invention are useful as analgesics and topical antiinflammatory agents for the treatment of various dermatoses and agents for the treatment of conditions where accumulation of cyclooxygenase and/or lipoxygenase metabolites is a causative factor.
    Type: Grant
    Filed: March 8, 1994
    Date of Patent: November 24, 1998
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Richard C. Allen, Grover C. Helsley, R. Richard L. Hamer, Brian S. Freed, John I. White, Lawrence L. Martin
  • (+)-.alpha.-(2,3-di methoxyphenyl)-1-?2-(4-flurophenyl)etyl!-4-piperidinemethanol
    Patent number: 5721249
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
  • Derivatives of 2,3-dihydro benzofuranols
    Patent number: 5721233
    Abstract: Derivatives of 2,3-dihydro-5-benzofuranol, intermediates thereof, and processes useful for their preparation. These compounds are free radical scavengers and are useful in the treatment of conditions capable of being treated by free radical scavengers, such as stroke, nervous system trauma and reperfusion damage.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: February 24, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: J. Martin Grisar, Margaret A. Petty, Frank Bolkenius
  • Anti-viral compounds
    Patent number: 5716973
    Abstract: This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-vital agents.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: February 10, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Daniel Schirlin, Viviane Van Dorsselaer, Celine Tarnus
  • Difluoro statone analogs
    Patent number: 5717093
    Abstract: This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-viral agents.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: February 10, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Daniel Schirlin, Viviane Van Dorsselaer, Celine Tarnus
  • (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluor ophenyl)ethyl!-4-piperidinemethanol
    Patent number: 5700813
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 23, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay
  • (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-pip eridinemethanol
    Patent number: 5700812
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-?2-(4-fluorophenyl)ethyl!-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 23, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay
  • Process for preparing 2,3-dihydro-benzofuranol derivatives
    Patent number: 5698696
    Abstract: This invention relates to a novel process for preparing 2,3-dihydro-benzofuranol derivatives and to the novel intermediates produced thereby.
    Type: Grant
    Filed: March 7, 1996
    Date of Patent: December 16, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gilbert Marciniak, Richard A. Schnettler, Timothy A. Ayers, Damian J. Krysan
  • Process for making (2S,5S)-5-fluoromethylornithine
    Patent number: 5637768
    Abstract: The present invention is directed to a process for making (2S,5S)-5-fluoromethylornithine through the reaction of wet penicillin acylase with (2R,5R) and (2S,5S)-6-fluoromethyl-3-(phenylactyl)-amino-2-piperidone and the addition of an acid to the resulting product.
    Type: Grant
    Filed: July 18, 1995
    Date of Patent: June 10, 1997
    Assignee: Merrell Pharmaceuticals, Inc.
    Inventors: Karin Jund, Jean-Bernard Ducep
  • Phosphonomethyldipeptides and process for preparation thereof
    Patent number: 5608078
    Abstract: Dipeptide compounds and analogs thereof having a phosphonomethyl moiety are disclosed. These compounds inhibit Endothelin Converting Enzyme and are thus useful in treating conditions responsive to inhibition of production of Endothelin.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: March 4, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Hugues d'Orchymont, Marc Bigaud
  • (+)-.alpha.-(2,3-dime thoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
    Patent number: 5561144
    Abstract: The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: October 1, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John M. Kane, David A. Hay, Christopher J. Schmidt
  • Difluoro statone analogs
    Patent number: 5559140
    Abstract: This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-viral agents.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: September 24, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Daniel Schirlin, Viviane Van Dorsselaer, Celine Tarnus