Patents Represented by Attorney, Agent or Law Firm Carolyn Favorito
  • Recombinant host cells for the production of polyketides
    Patent number: 6177262
    Abstract: Yields of polyketides produced in host cells such as Streptomyces can be increased by coexpression of the ptpA gene. The introduction of recombinant vectors encoding ptpA and polyketide synthase genes is more efficient and does not require methyl-free DNA if the host cell is a restriction/methylation deficient strain, such as Streptomyces lividans K4-114, K4-155, or K27-39.
    Type: Grant
    Filed: October 28, 1998
    Date of Patent: January 23, 2001
    Assignee: Kosan Biosciences, Inc.
    Inventors: Rainer Ziermann, Mary C. Betlach
  • Sorangium polyketide synthase
    Patent number: 6090601
    Abstract: Domains of epothilone polyketide synthase, and polynucleotides encoding therefor. Additionally, chimeric polyketide synthases that include domains, or subsets of domains, patterned on epothilone polyketide synthase. Methods to prepare epothilone in pharmaceutically useful quantitites are described, as are methods to prepare polyketide combinatorial libraries.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: July 18, 2000
    Assignee: Kosan Bioscience
    Inventors: Claes Gustafsson, Mary C. Betlach