Patents Represented by Attorney Casimir Jones

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  • genes and proteins and variants, and therapeutic compositions and methods of utilizing the same
    Patent number: 8273714
    Abstract: The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and recombinant wild-type forms of ADAMTS13, as well as mutant and variant forms including fragments, some of which posses altered characteristics relative to the wild-type ADAMTS13. The present invention also relates to methods of using ADAMTS13, including for treatment of TTP. The present invention also relates to methods for screening for the presence of TTP. The present invention further relates to methods for developing anticoagulant drugs based upon ADAMTS13.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: September 25, 2012
    Assignee: The Regents of The University of Michigan
    Inventors: David Ginsburg, Gallia Levy, Han-Mou Tsai
  • 5?-modified bicyclic nucleic acid analogs
    Patent number: 8268980
    Abstract: The present invention provides 5?-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5?-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: September 18, 2012
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Punit P. Seth, Eric E. Swayze, Balkrishen Bhat