Patents Represented by Attorney, Agent or Law Firm Chalin A. Smith
  • Patent number: 6723532
    Abstract: A method for reconstituting Sendai viral particles by transfecting Sendai virus to a host expressing all genes for the initial replication has been developed, enabling the Production of negative strand RNA vectors highly useful for practical applications.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: April 20, 2004
    Assignee: Dnavec Research Inc.
    Inventors: Yoshiyuki Nagai, Atsushi Kato, Fukashi Murai, Makoto Asakawa, Tsuneaki Sakata, Mamoru Hasegawa, Tatsuo Shioda
  • Patent number: 6645760
    Abstract: A method for reconstituting Sendai viral particles by transfecting Sendai virus to a host expressing all genes for the initial replication has been developed, enabling the production of negative strand RNA vectors highly useful for practical applications.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: November 11, 2003
    Assignee: Dnavec Research Inc.
    Inventors: Yoshiyuki Nagai, Atsushi Kato, Fukashi Murai, Makoto Asakawa, Tsuneaki Sakata, Mamoru Hasegawa, Tatsuo Shioda
  • Patent number: 6562864
    Abstract: Described herein are catechin multimers, and particularly substituted catechin multimers, and their use as carrier moieties for the delivery of nucleophilic and cationic bioactive therapeutic agents to target sites in vivo. For example, substituted catechin multimers of the present invention may be administered alone, for the treatment of stenotic vascular diseases and disorders, such as atherosclerosis (also known as arteriosclerosis) and coronary heart disease (also known as coronary artery disease and ischemic heart disease).
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: May 13, 2003
    Inventor: Drake Larson
  • Patent number: 6557492
    Abstract: A live fish transport system is described herein. In particular, a modular live fish transport tote, an oxygen delivery system, an automated water treatment and delivery apparatus, and a chemically and biologically balanced aquaculture solution are described. Methods of making and using these components, either alone or in combination with each other, are also described.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: May 6, 2003
    Assignee: Sea Chick, Inc.
    Inventor: Donald Robohm
  • Patent number: 6423742
    Abstract: Described herein are novel, therapeutic pharmaceutical and nutraceutical compositions useful for treating stenotic vascular diseases and disorders, such as atherosclerosis and coronary artery disease, and reducing formation of plaque on vascular walls and methods of using same. More particularly, the present invention relates to dietary supplements comprised of gallic acid, or a derivative thereof, in combination with limonene, or a derivative thereof, formulated so as to effectively reduce plaque formation, reversing plaque deposition and degenerative changes in the arterial walls, and/or removal of existing plaques from the vascular walls of animals, preferably humans. The dietary supplements may be formulated “neat” (e.g., without additives) or with additives such as pharmaceutical carriers, diluents, buffers, adjuvants, excipients, surfactants, and stabilizers.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: July 23, 2002
    Inventor: Drake Larson
  • Patent number: 6204004
    Abstract: Several EHEC proteins which are secreted into the culture supernatant have been discovered. These proteins are not produced by non-pathogenic E. coli, and produce a strong serum antibody response in patients with HUS and bloody diarrhea.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: March 20, 2001
    Assignee: University of Maryland, Baltimore
    Inventors: James B. Kaper, Karen Jarvis
  • Patent number: 6197258
    Abstract: The invention described in detail herein relates to the detection, determination, and quantitation of certain ions and small molecules in solution. The invention specifically relates to improvements in the area of photoluminescent sensors for use in a detection scheme involving the alteration of a photoluminescent label or moiety attached to or associated with an analyte binding macromolecule. One may use the changes in photoluminescence lifetime, changes in ratios of photoluminescence intensity or changes in photoluminescence polarization (anisotropy) to determine the analyte. The photoluminescence change measured correlates to the concentration of the ion or molecule in solution.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: March 6, 2001
    Assignee: University of Maryland, Baltimore
    Inventors: Richard B. Thompson, Vincent L. Feliccia, Badri P. Maliwal, Carol A. Fierke
  • Patent number: 5962645
    Abstract: A novel antiproliferative factor (APF) present in urine of patients with interstitial cystitis (IC) is described. This urine antiproliferative factor can serve as a marker for disease activity and its antagonists as therapeutic medicaments for IC. In addition, APF and its agonists can be used for treating diseases associated with cell proliferation.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: October 5, 1999
    Assignee: University of Maryland
    Inventors: Susan Keay, John W. Warren, Michael Kleinberg, Michael K. Hise