Abstract: A novel antiproliferative factor (APF) present in urine of patients with interstitial cystitis (IC) is described. This urine antiproliferative factor can serve as a marker for disease activity and its antagonists as therapeutic medicaments for IC. In addition, APF and its agonists can be used for treating diseases associated with cell proliferation.
Type:
Grant
Filed:
October 3, 1997
Date of Patent:
October 5, 1999
Assignee:
University of Maryland
Inventors:
Susan Keay, John W. Warren, Michael Kleinberg, Michael K. Hise