Abstract: A valve drive for an internal combustion engine having at least one camshaft which has a toothed shaft (2) and at least one cam part (3) with a plurality of different cam paths (13, 14) arranged adjacent to one another for the variable actuation of gas exchange valves (8) by displacement of the cam parts (3) by means of actuators (actuator pins 4 and 5) on the toothed shaft (2), the toothed shaft (2) having a shaft profile (9) and the cam parts (3) having a hub profile (10) which is matched to said shaft profile (9), and the number of wedges, notches or teeth (19) of the shaft profile (9) and of the hub profile (10) being such that the different cam positions for four-stroke internal combustion engines of any type such as in-line engines, V-engines or W-engines, and with any numbers of cylinders, can be provided with the same toothed shafts (2) and cam parts (3).

Abstract: Novel derivatives of amidines of formula wherein the substituents are defined as in the specification which are useful for inhibiting activity on NO-synthase enzymes producing nitrogen mono oxide and/or trapping the reactive oxygen species (ROS) making them useful for treating various diseases.

Abstract: What is proposed is a hydraulic lash adjuster (1), for example for a valve train of an internal combustion engine. The lash adjuster (1) comprises a hollow cylindrical housing (2) that is inter-inserted with an axially relatively displaceable pressure piston (3). A high pressure chamber (6) for hydraulic medium extends between opposing front ends (4, 5) of the pressure piston (3) and the housing (2). The high pressure chamber (6) can be supplied, via a one-way valve (8) arranged on the front end (4) and opening towards the high pressure chamber (6) with hydraulic medium out of a reservoir (9). A leak gap (12) for the hydraulic medium is formed between an outer peripheral surface (10) of the pressure piston (3) and a bore (11) of the housing (2). In its portion adjoining the front end (5) of the housing (2), the bore (11) of the housing (2) merges into an annular enlargement (15).

Abstract: A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive oxygen species useful for treating inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.

Abstract: A method of treating in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an amount of a compound of the formula wherein the substituents are defined in accordance with the disclosure.

Abstract: A hydraulic reverse spring valve clearance compensation element (RSHVA) for a valve train of an internal combustion engine comprising: a housing (2), which has a blind bore (3), in which a piston (4) is guided with a tight, sealing clearance; the piston (4) comprises a lower piston part (4a) with a lower piston head (5), which together with the blind bore (3) defines a high-pressure chamber (7), whilst a low-pressure chamber (8) is situated above the lower piston head (5); the pressure chambers (7, 8) being connected by a central axial bore (10) in the lower piston head (5), which is controlled by a control valve (11) arranged on the underside (23) of the lower piston head (5); the control valve (11) comprises a control valve ball (19), upon which a control valve spring (20) acts in the opening direction and the lift of which is limited by a lift-limiting stop (24) of a valve ball cap (21), whereby an RSHVA, the idle lift of which is as independent as possible of the viscosity and hence of the temperature

Abstract: A guide carriage of a linear roller bearing, having at least one endless raceway for rolling bodies (9), and having a carrying body (1), on the two longitudinal sides of which in each case one carrying section (2, 3) and one return section (5, 6) of the endless raceway is provided, the carrying section (2, 3) being provided rolling bodies (9) which roll under load and the return section (5, 6) being provided for rolling bodies (9) which return without load, and having head pieces (13) which are arranged on end sides of the carrying body (1) and in each case have one deflection section (11, 12) which connects the return section (5, 6) to the carrying section (5, 6) a lubricant channel (24) being provided for the supply of lubricant, which lubricant channel (24) can be connected to the raceway of the rolling body (9) via a valve (30), the valve (30) having a slot (33) which is provide for the passage of lubricant, crosses the cross section of the lubricant channel (24) and is delimited by slot faces (34), the s

Abstract: A method for forming a noble metal coating on a gas diffusion medium substantially free of ionomeric components comprising subjecting an electrically conductive web to a first ion beam having an energy not higher than 500 eV, then to a second beam having an energy of at least 500 eV, containing the ions of at least one noble metal and electrodes provided by the method.

Abstract: A valve timing mechanism of an internal combustion engine of a motor vehicle, having a camshaft having at least one cam (18), via which a switchable valve timing mechanism element (1) can be loaded with a cam stroke (s), in which locking means (12) are arranged on the valve timing mechanism element (1), which locking means (12) have a locking play (16) which is active in the direction of a valve stroke, in which the cam (18) has a base circle region (?) and a ramp region (19) with an opening ramp (?) which adjoins the base circle region (?), and in which at least one ramp section (21) is formed on the opening ramp (?) in order to compensate for the locking play (16).

Abstract: This mounting system features a base displaced from a mounting plate which is used to anchor a base mounted receiver releasably. The base has a pair of flexible arms to engage the receiver in channels that have a catch edge at the ends of the channels. The base is constructed with at least one stabilizer element and the receiver has an appropriate alignment slot. Each mounting plate, on both the base and receiver, have a plurality of apertures to facilitate attachment to fabric or a fabric patch or a fabric envelope which thereby allows attachment to different fabric devices together in a releasable yet secure manner. Those devices are to be from the following group, non-exclusive; backpack, jacket, hunting jacket, binocular case, knife case, compass case, first aid case, ammunition pouch, animal call case, web gear, etc.

Abstract: A method of treating cardiac rhythm disorders linked with neurodegenerating depression, bipolar disorders and irritable bowel disorders in warm-blooded animals in need thereof by administering a compound of the formula wherein the substituents are defined as in the specification.

Abstract: A switchable cam follower (1) is proposed which serves to transmit a cam stroke in a variable manner from a cam to valve timing mechanism elements of an internal combustion engine. The cam follower (1) comprises substantially a cylindrical inner part (5) and a cylindrical outer part (2) which can be displaced into one another in the direction of their longitudinal axes and can be locked and unlocked in a relative position by means of coupling means (10) which are preferably actuated by pressure-modulated hydraulic medium, and also comprises at least one spring means (7) which is arranged between the inner part (5) and the outer part (2). The inner part (5) has a run-on surface (16) for the cam at one end side (17) and is radially guided in an inner wall (4) of the outer part (2) by way of an outer circumferential surface (6).

Abstract: The invention describes a current collector for electrochemical cells, consisting of a sandwich of compressible and resilient layers of metal wires, which imparts a predetermined mechanical load under a broad compression range.

Abstract: A linear guide unit comprising a guide carriage (3) that is mounted through rolling elements (2) for sliding on a guide rail (1), said guide carriage (3) comprising a carrier body (4) and end caps (5) arranged on front ends of the carrier body (4), the linear guide unit comprising at least one endless rolling element channel (6) comprising a load-bearing channel (7) for load-bearing rolling elements (2), a return channel (8) for returning rolling elements (2) and two deflecting channels (9) that connect the load-bearing channel (7) and the return channel (8) endlessly to each other and are defined by the end caps (5), a support rail (10) arranged along the load-bearing channel (7) and supported on the carrier body (4) comprising a raceway (16) for the rolling elements (2) that defines the load-bearing channel (7) the support rail (10) comprising a support member (11) and a saddle member (12), the support member (11) being received on the carrier body (4), and the saddle member (12) comprising the raceway (16)

Abstract: The invention proposes a variable valve train (1) for a gas exchange valve (8) of an internal combustion engine, which gas exchange valve (8) is actuated by a cam (2), said valve train (1) comprising a force transmission device (4) that is arranged between the cam (2) and the gas exchange valve (8) and includes a hydraulic lifting device (9) comprising a pressure piston (10) that is arranged for longitudinal displacement in a cylinder (12), said pressure piston (10) defining a pressure chamber (13) that is connected to a pressure medium supply of the internal combustion engine and said pressure piston (10) permitting, under high-pressure loading, an actuation of the gas exchange valve (8) independently of the cam (2). The force transmission device (4) is configured as an oscillating lever or rocker arm (3) mounted for pivoting on a lever shaft (6) comprising a longitudinal channel (14) that transports pressure medium and acts as a link (15) between the pressure medium supply and the pressure chamber (13).

Abstract: A method for strategy independent optimization of a multi-objective function of a portfolio containing at least one investment is disclosed. The method involves the use of genetic algorithms to arrive at function optimization. A suite of strategies is provided enabling the user to select a strategy and optimize a function. Real world data is drawn from exchanges and is utilized for replication. The invention also discloses a novel combination of apparatus for carrying out the method of invention, typically, using parallel processing.

Abstract: A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.

Abstract: The invention relates to a method of setting the ball travel of a valve-closing body, designed as valve ball, of a control valve of a hydraulic valve-lash-adjusting element which has a plunger with a plunger head and a central bore, a valve seat being provided at the outer end of this central bore, this valve seat being controlled by a valve ball, the ball travel of which is limited by a valve cap which has a cap flange and a cap base, the cap flange resting with its bearing surface on a base of a recess of the plunger head, and a stop of the cap base serving as a travel limit for the valve ball.

Abstract: The invention relates to a device (101) for varying the control times of gas exchange valves of an internal combustion engine, with a hydraulic actuation device (102) and with a control valve (103). The device (101) according to the invention is provided with mid-position locking of a hydraulic actuation device (102). Furthermore, the device (101) according to the invention ensures that, in the event of the failure of an actuation unit (112) which regulates the control valve (103), the hydraulic actuation device (102) is locked in the mid-position and the lock is maintained until the actuation unit (112) is repaired. Furthermore, the device (101) according to the invention makes it possible to start the internal combustion engine in a position locked in a mid-position, without a movable element (105) of the hydraulic actuation device (102) butting against a side wall of a pressure space (104) when the internal combustion engine is started.

Abstract: The invention relates to a human GHRH-binding protein (human Growth Hormone-releasing hormone). Said protein, which is obtained from the Pilocarpus Heterophyllus plant, can be used to prepare medicaments intended to antagonise the effects of GHRH and to treat proliferative diseases (particularly cancer), acromegaly or diabetic nephropathies and retinopathies.