Patents Represented by Attorney, Agent or Law Firm Charles E. Kinzig
  • Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
    Patent number: 6699879
    Abstract: The present invention provides phenyl urea and phenyl thiourea derivatives which are non-peptide antagonists of human orexin receptors, in particular orexin-1 receptors, of formula (I) in which: Z represents oxygen or sulfur; and R1 to R7 represent various substituent groups; and pharmaceutically acceptable salts thereof. In particular, these compounds are of potential use in the treatment of obesity including obesity observed in Type 2(non-insulin-dependent) diabetes patients and/or sleep disorders.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: March 2, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Steven Coulton, Amanda Johns, Roderick Alan Porter