Patents Represented by Attorney Charles J. Knuth

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  • Antiinflammatory salts of piroxicam
    Patent number: 4567179
    Abstract: Improved antiinflammatory salts of piroxicam with antidepressant doxepin, with bronchodilator pirbuterol or isoproterenol, with H.sub.2 -antagonist inhibitor 2-guanidino-4-(2-methyl-4-imidazolyl)thiazole, with pyridoxine, a member of the vitamin B.sub.6 complex, or with antihypertensive trimazosin.
    Type: Grant
    Filed: October 11, 1984
    Date of Patent: January 28, 1986
    Assignee: Pfizer, Inc.
    Inventor: Joseph G. Lombardino
  • High temperature drilling fluids
    Patent number: 4566978
    Abstract: An aqueous drilling fluid suitable for high-temperature use comprising a water base, clay suspended in said base and from about 0.01-25 pounds per barrel total composition of a hydrolyzed terpolymer of maleic anhydride, styrene and a third monomer selected from acrylamide, methacrylamide, acrylic acid or methacrylic acid, the molar ratio of maleic anhydride to styrene to said third monomer being from about 30:10:60 to 50:40:10, and the alkali metal, ammonium and lower aliphatic amine salts thereof, the weight-average molecular weight of said hydrolyzed terpolymer being from about 500-10,000. An improved drilling process wherein such fluids remain flowable at elevated temperatures is also disclosed.
    Type: Grant
    Filed: May 21, 1984
    Date of Patent: January 28, 1986
    Assignee: Pfizer Inc.
    Inventors: Randel E. Stong, Stanley W. Walinsky
  • Hypoglycemic 5-pyrrolyl, indolyl and quinolyl substituted oxazolidine-2,4-diones and their use
    Patent number: 4565820
    Abstract: Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]-furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.
    Type: Grant
    Filed: January 26, 1984
    Date of Patent: January 21, 1986
    Assignee: Pfizer Inc.
    Inventor: Rodney C. Schnur
  • Acyltripeptide immunostimulants
    Patent number: 4565653
    Abstract: Acyltripeptides having the formula below, pharmaceutically acceptable salts thereof and intermediates therefor; processes for their preparation and use as immunostimulant and antibacterial agents. ##STR1## wherein R.degree. is C.sub.1-6 alkyl; x is an integer and is 1 to 4.
    Type: Grant
    Filed: March 30, 1984
    Date of Patent: January 21, 1986
    Assignee: Pfizer Inc.
    Inventors: Jeffrey L. Ives, Frank C. Sciavolino
  • Antiinflammatory methods
    Patent number: 4564614
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as piroxicam, or a pharmaceutically acceptable salt thereof, with pyridoxine.
    Type: Grant
    Filed: January 28, 1985
    Date of Patent: January 14, 1986
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
  • Animal growth promotant L-pyroglutamyl-pyridylalanyl-L-prolinamides
    Patent number: 4562197
    Abstract: L-pyroglutamyl-pyridylalanyl-L-prolinamides of the formula: ##STR1## wherein R.sup.1 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl or aryl; and X is H, halo, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; and their physiologically acceptable salts and feed compositions thereof are useful for improving the efficiency of feed utilization and/or growth of animals especially poultry.
    Type: Grant
    Filed: November 13, 1984
    Date of Patent: December 31, 1985
    Assignee: Pfizer Inc.
    Inventors: Michael Snarey, Peter J. Swift, Michael J. Witty
  • Intermediates of hypoglycemic 5-substituted oxazolidine-2,4-diones
    Patent number: 4562267
    Abstract: Variously substituted alkyl 2-(furyl or thienyl)-2-hydroxyacetates and 2-(furyl or thienyl)-2-hydroxyacetamides are useful as intermediates for hypoglycemic oxazolidine-2,4-diones.
    Type: Grant
    Filed: October 14, 1983
    Date of Patent: December 31, 1985
    Assignee: Pfizer Inc.
    Inventor: Rodney C. Schnur
  • 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
    Patent number: 4560690
    Abstract: 2,4-Disubstituted thiazole compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof wherein X is NH and Y is CH or N, orX is S and Y is CH;R.sup.1 is certain straight or branched chain alkyl groups, (R.sup.3).sub.2 C.sub.6 H.sub.3, or (R.sup.3).sub.2 Ar(CH.sub.2).sub.n where n is an integer from 1 to 4, R.sup.3 is H or certain substituent groups and Ar is phenylene, naphthalene or the residue of certain heteroaromatic groups;R.sup.2 is H or (C.sub.1 -C.sub.4)alkyl; orR.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached form certain heterocyclic groups; andR.sup.4 is H, (C.sub.1 -C.sub.5)alkyl, NH.sub.2 or CH.sub.2 OH; a method for their use in treatment of gastric ulcers in mammals and pharmaceutical compositions containing said compounds.
    Type: Grant
    Filed: April 30, 1984
    Date of Patent: December 24, 1985
    Assignee: Pfizer Inc.
    Inventor: Lawrence A. Reiter
  • 1,3-Bis-(1H-1,2,4-triazol-1-yl)-2-perfluoro-alkylpropan-2-ol antifungal agents
    Patent number: 4560697
    Abstract: Compounds of the formula ##STR1## or a pharmaceutically or agriculturally acceptable acid addition salt thereof wherein R is (C.sub.1 -C.sub.5) perfluoroalkyl and R.sup.1 is H or CH.sub.3, method for their use in combatting fungal infections in plants, seeds and animals, including humans; and as antileishmanial agents, and pharmaceutical and agricultural compositions containing them.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: December 24, 1985
    Assignee: Pfizer Inc.
    Inventors: Kenneth Richardson, Peter J. Whittle
  • Dihydropyridine derivatives of 1,4:3,6-dianhydrohexitols
    Patent number: 4559351
    Abstract: The present invention relates to new acyl derivatives of 1,4:3,6-dianhydrohexitols, processes for their preparation and drugs containing the same. The new compounds have a cardiovascular effect and can be used as antihypertensive agents, as peripheral and central vasodilators and as coronary therapeutic agents.
    Type: Grant
    Filed: June 26, 1984
    Date of Patent: December 17, 1985
    Assignee: Heinrich Mack Nachf.
    Inventors: Peter Stoss, Matyas Leitold
  • Antiinflammatory compositions and methods
    Patent number: 4559326
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as prioxicam, or a pharmaceutically acceptable salt thereof, with inositol.
    Type: Grant
    Filed: January 31, 1985
    Date of Patent: December 17, 1985
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
  • Method of treating diarrhoea using indole compounds
    Patent number: 4558048
    Abstract: Substituted phenylindoles, useful as anti-diarrhoeal agents and having the formula: ##STR1## and the pharmaceutically-acceptable acid addition salts thereof; wherein R is hydrogen, chloro, bromo, --CH(OH).Ph or --CH(OH).cyclohexyl; each Ph is phenyl or substituted phenyl; n is an integer of from 2 to 7; and each of R.sup.1 and R.sup.2 is hydrogen or (C.sub.1 -C.sub.4) alkyl, or R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached form a heterocyclic group; and a method for the treatment of diarrhoea by the administration of said agents.
    Type: Grant
    Filed: March 27, 1985
    Date of Patent: December 10, 1985
    Assignee: Pfizer Inc.
    Inventor: Robert J. Bass
  • Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
    Patent number: 4556676
    Abstract: Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalen amine and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: September 5, 1980
    Date of Patent: December 3, 1985
    Assignee: Pfizer Inc.
    Inventors: Willard M. Welch, Jr., Charles A. Harbert, B. Kenneth Koe, Allen R. Kraska
  • 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
    Patent number: 4556672
    Abstract: Certain new 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and anti-inflammatory agents in mammalian subjects. In particular, the compounds of the invention are useful for ameliorating or eliminating pain in human subjects recovering from surgery or trauma, and in alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: December 3, 1985
    Assignee: Pfizer Inc.
    Inventor: Saul B. Kadin
  • Spiro-3-hetero-azolones for treatment of diabetic complications
    Patent number: 4556670
    Abstract: Spiro-oxazolidones, -thiazolidones and -imidazolidones are disclosed which are useful as aldose reductase inhibitors and as therapeutic agents for the treatment of complications arising from diabetes. Pharmaceutical compositions containing the spiro compounds and a method of treating diabetic complications are also disclosed.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: December 3, 1985
    Assignee: Pfizer Inc.
    Inventor: Christopher A. Lipinski
  • Membrane oxygenator
    Patent number: 4556489
    Abstract: A novel device for mass transfer across a membrane is disclosed, which is particularly suitable for use as a blood oxygenator. The novel device is of the type having a pleated, selectively permeable membrane defining first and second sets of alternating pockets for the flow of a fluid to be treated (e.g. blood) and a treating fluid (e.g. oxygen), and a discrete support screen disposed within each of the pockets of said first and second sets. Of considerable importance is the feature that the support screens are designed to be substantially interdigitated when the assembly of membrane and support screens is held as a compressed stack within the housing of the device. The novel mass transfer apparatus may be utilized as a compact blood oxygenator with excellent gas transfer rates, low pressure drops and negligible trauma to blood components.
    Type: Grant
    Filed: March 9, 1983
    Date of Patent: December 3, 1985
    Assignee: Shiley Incorporated
    Inventors: Lambert J. Diettrich, Jr., Francis M. Servas
  • N-Benzyl-imidazoles as selective inhibitors of the thromboxane synthetase enzyme
    Patent number: 4555516
    Abstract: The N-(substituted benzyl) imidazoles are selective enzyme inhibitors and thus are useful in the treatment of heart disease, circulatory and vascular problems.
    Type: Grant
    Filed: January 9, 1980
    Date of Patent: November 26, 1985
    Assignee: Pfizer Inc.
    Inventors: Peter E. Cross, Roger P. Dickinson
  • Heat exchanger with gas venting means
    Patent number: D281717
    Type: Grant
    Filed: February 24, 1982
    Date of Patent: December 10, 1985
    Assignee: Shiley Incorporated
    Inventors: Todor Pavlov, Badri Gupta
  • Rasp handle
    Patent number: D282238
    Type: Grant
    Filed: April 15, 1983
    Date of Patent: January 21, 1986
    Assignee: Howmedica, Inc.
    Inventor: Robert V. Kenna
  • Guide for femoral neck osteotomy
    Patent number: D282277
    Type: Grant
    Filed: April 15, 1983
    Date of Patent: January 21, 1986
    Assignee: Howmedica, Inc.
    Inventor: Robert V. Kenna