Abstract: A process which comprises extracting 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl) distannoxane from a mixture containing 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane, a sucrose-6-ester, and polar aprotic solvent, which process comprises the steps of:(a) contacting said mixture, in the presence of a small amount of water, with an organic solvent that is substantially immiscible with water to form thereby an extraction mixture, wherein the amount of water employed is sufficient to cause efficient partitioning of said 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane from a first phase comprising said polar aprotic solvent into second phase comprising said organic solvent;(b) agitating the extraction mixture for a period of time and at a temperature sufficient to form thereby a two-phase mixture wherein the preponderance of the 1,3-diacyloxy-1,1,3,3-tetra(hydrocabyl)distannoxane in the extraction mixture is contained in said second phase and essentially all of the sucrose-6-ester in the extraction mixture
Abstract: (1H-azol-1-ylmethyl)substituted quinoxaline derivatives, compositions containing the same, and methods of treating mammals suffering from disorders which are characterized by an increased proliferation and/or abnormal differentiation of epithelial tissues.
Type:
Grant
Filed:
November 13, 1989
Date of Patent:
July 2, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Marc G. Venet, Gerard C. Sanz, Alfons H. M. Raeymaekers, Eddy J. E. Freyne
Abstract: A method of improving sleep in warm-blooded animals suffering from sleep disorders, which method comprises the administration of particular N-aryl-piperazinealkanamide derivatives and compositions containing the same. Novel N-aryl-piperazinealkanamide derivatives.
Type:
Grant
Filed:
September 20, 1990
Date of Patent:
June 25, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Georges H. P. Van Daele, Freddy F. Vlaeminck, Marc G. C. Verdonck
Abstract: Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines having antihistaminic and serontonin-antagonistic properties which compounds are useful agents in the treatment of allergic diseases.
Type:
Grant
Filed:
December 7, 1989
Date of Patent:
June 18, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Frans E. Janssens, Joseph L. G. Torremans, Jozef F. Hens, Theophilus T. J. Van Offenwert
Abstract: Process which comprises reacting sucrose with a di-(hydrocarbyl)tin oxide in an inert organic reaction vehicle with removal of water for a period of time and at a temperature sufficient to produce a 1,3-di-(6-O-sucrose)-1,1,3,3-tetra(hydrocarbyl)distannoxane.
Type:
Grant
Filed:
April 23, 1990
Date of Patent:
June 11, 1991
Assignee:
Noramco, Inc.
Inventors:
David S. Neiditch, Nicholas M. Vernon, Robert E. Wingard, Jr.
Abstract: 3-Piperazinyl-1,2-benzazoles and their pharmaceutically acceptable acid addition salts having useful antipsychotic properties and being useful in the treatment of a variety of disorders in which serotonin and/or dopamine release is of predominant importance.
Type:
Grant
Filed:
June 11, 1990
Date of Patent:
May 14, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
Abstract: Synergistic antifungal compositions containing imazalil and propiconazole. Methods of treating plants comprising the administration of imazalil and propiconazole.
Type:
Grant
Filed:
April 7, 1989
Date of Patent:
May 7, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Jozef F. E. Van Gestel, Jan R. Nys, Paul F. M. Ruelens
Abstract: 2-(Heterocyclylalkyl)imidazopyridines having antihistaminic properties, compositions containing these compounds as active ingredient and novel 2-(Heterocyclylalkyl)imidazopyridines.
Type:
Grant
Filed:
August 2, 1990
Date of Patent:
April 30, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Frans E. Janssens, Francois M. Sommen, Joseph L. G. Torremans, Gaston, S. M. Diels
Abstract: Benzoxazol- and benzothiazolamine derivatives having anti-anoxic properties which compounds are useful in the treatment of anoxia. These compounds are produced from certain benzoxazol- and benzothizolamine intermediates.
Type:
Grant
Filed:
August 24, 1989
Date of Patent:
April 23, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Raymond A. Stokbroekx, Marcel G. M. Luyckx, Frans E. Janssens
Abstract: 2-Amino-pyrimidininone derivatives possessing antihistaminic and serotonin-antagonistic properties. Compositions containing these compounds as the active ingredient and a method of treating subjects from allergic diseases.
Type:
Grant
Filed:
December 26, 1989
Date of Patent:
April 16, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Frans E. Janssens, Ludo E. J. Kennis, Francois M. Sommen, Ann C. J. Dierckx
Abstract: Novel N-(4-piperindyl)bicyclic condensed 2-imidazolamine derivatives and their pharmaceutically acceptable acid addition salts having anti-histaminic properties, compositions containing the same, and methods of treating allergic diseases in warm-blooded animals.
Type:
Grant
Filed:
December 4, 1989
Date of Patent:
April 9, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Frans E. Janssens, Joseph L. G. Torremans, Gasto S. M. Diels
Abstract: Novel herbicidal 1,5-substituted 1H-imidazole derivatives, compositions containing these compounds as active ingredients, and a method for controlling weeds, preferably selectively in crops of useful plants. Further the invention also relates to a process for making these novel compounds.
Type:
Grant
Filed:
October 12, 1989
Date of Patent:
February 19, 1991
Assignees:
Janssen Pharmaceutica N.V., Ciba-Geigy
Inventors:
Marcel F. L. De Bruyn, Guy R. E. Van Lommen, William R. Lutz
Abstract: Novel pyridazinamine derivatives having antiviral activity, compositions containing these compounds as active ingredient, and a method of destructing viruses or preventing the growth thereof in warm-blooded animals suffering from diseases caused by these viruses. Processes for preparing said compounds and compositions.
Type:
Grant
Filed:
November 9, 1988
Date of Patent:
February 12, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Raymond A. Stokbroekx, Marcel J. M. Van der Aa, Marcel G. M. Luyckx, Gilbert A. J. Grauwels
Abstract: A method of treating warm-blooded animals suffering from diarrhea, which method comprises the administration of particular 4-(aroylamino)piperidinebutanamide derivatives and compositions containing the same. Novel 4-(aroylamino)piperidinebutanamide derivatives.
Type:
Grant
Filed:
September 8, 1989
Date of Patent:
February 5, 1991
Assignee:
Janssen Pharmaceutica
Inventors:
Georges H. P. Van Daele, Freddy F. Vlaeminck, Francois M. Sommen, Michel A. J. De Cleyn
Abstract: [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines and their pharmaceutically acceptable acid addition salts having anti-histaminic properties, compositions containing the same, and methods of treating allergic diseases in warm-blooded animals.
Type:
Grant
Filed:
April 13, 1989
Date of Patent:
January 29, 1991
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Frans E. Janssens, Gaston S. M. Diels, Geert M. E. Pille
Abstract: A process for the chlorination of sucrose-6-esters to produce 6',4,1'-trichlorosucrose-6-esters which comprises the steps of:(a) adding at least seven molar equivalents of an acid chloride to a reaction mixture containing a sucrose-6-ester and a tertiary amide to form initially a chloroformiminium chloride salt which subsequently forms a complex with the hydroxyl groups of the sucrose-6-ester;(b) subjecting the reaction mixture product of step (a) to an elevated temperature not higher than about 85.degree. C. for a period of time sufficient to produce a mixture of chlorinated sucrose-6-ester products consisting essentially of 6'-chlorosucrose-6-ester, 4,6'-dichlorosucrose-6-ester, and 1',6'-dichlorosucrose-6-ester; and(c) subjecting the reaction mixture product of step (b) to an elevated temperature not higher than about 125.degree. C. for a period of time sufficient to produce a chlorinated product consisting essentially of 1',4,6'-trichlorosucrose-6-ester.
Type:
Grant
Filed:
July 18, 1989
Date of Patent:
December 25, 1990
Assignee:
Noramco, Inc.
Inventors:
Robert E. Walkup, Juan L. Navia, Nicholas M. Vernon
Abstract: Substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides, their N-oxide forms, their pharmaceutically acceptable acid addition salts and stereochemically isomeric forms having gastrointestinal motility stimulating properties, compositions containing the same, and methods of treating warm-blooded animals suffering from motility disorders of the gastrointestinal system.
Type:
Grant
Filed:
September 2, 1988
Date of Patent:
December 4, 1990
Assignee:
Janssen Pharmaceutical N.V.
Inventors:
Georges H. P. Van Daele, Freddy F. Vlaeminck, Michel A. J. De Cleyn
Abstract: A method of improving sleep in warm-blooded animals suffering from sleep disorders, which method comprises the administration of particular N-aryl-piperazinealkanamide derivatives and compositions containing the same. Novel N-aryl-piperazinealkanamide derivatives.
Type:
Grant
Filed:
October 10, 1989
Date of Patent:
November 6, 1990
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Georges H. P. Van Daele, Freddy F. Vlaeminck, Marc G. C. Verdonck
Abstract: Novel [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters, compositions containing the same, and methods of treating clinical conditions related with the production of thromboxane A.sub.2, prostacyclin and/or prostaglandins D.sub.2, E.sub.2 and F.sub.2.alpha..
Type:
Grant
Filed:
May 23, 1989
Date of Patent:
October 16, 1990
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Eddy J. E. Freyne, Alfons H. M. Raeymaekers, Victor Sipido, Marc G. Venet