Patents Represented by Attorney, Agent or Law Firm Charles LiMuti
  • Method for the determination of a specific binding ligand using a vanadium bromoperoxidase as a signal-generating enzyme
    Patent number: 6322992
    Abstract: An analytical element can be used to sensitively and rapidly detect a wide variety of specific binding ligands in either a competitive or sandwich assay format. The assays are carried out using a vanadium bromoperoxidase-labeled immunoreactant and a chemiluminescent signal-providing wash composition which comprises a 2,3-dihydro-1,4-phthalazinedione derivative; a halogen, pseudohalogen, halogen-providing source or pseudohalogen-providing source; and a peroxide or a peroxide-generating reagent composition.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: November 27, 2001
    Assignee: Johnson & Johnson Clinical Diagnostics, Inc.
    Inventors: Alan Eric Friedman, Thomas Robert Kissel, Sarah Fingar Groulx, Martha Miller Kopcienski
  • Format for minimizing interferences in chemiluminescent thin-film immunoassays
    Patent number: 6090568
    Abstract: A multilayer dry immunoassay element comprising 1) a spreading layer having a sample application area and a signal read area and 2) a separate receptor layer residing on 3) a radiation-transmissive support characterized in that the spreading layer contains a light absorbing material.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: July 18, 2000
    Assignee: Clinical Diagnostic Systems, Inc.
    Inventors: Richard Troconis Belly, Caroline Erdrich, Richard Calvin Sutton
  • Dry analytical elements for the determination of protein
    Patent number: 6046052
    Abstract: A dry analytical element is disclosed which can be used to sensitively and rapidly detect and quantitate protein. The assays are carried out using a dye that reacts with protein and molybdate ion to produce a measurable change in the spectral absorption of the dye. Also disclosed are polymers which stabilize and enhance the accuracy of the assay, and compounds which reduce interference by bicarbonate.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: April 4, 2000
    Assignee: Ortho Clinical Diagnostics, Inc.
    Inventors: Thomas Arter, David B. LaTart, John C. Mauck, Richard C. Sutton, Wayne Weber, Robert Winterkorn, James Schaeffer