Patents Represented by Attorney Charles M. Carusso

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  • Diphosphonate intermediate for preparing an antihypercalcemic agent
    Patent number: 5039819
    Abstract: Described is a new diphosphonate intermediate useful in a new process for producing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP), a new antihypercalcemic agent. The process involves a 3-step sequence starting with 4-phthalimidobutanoyl chloride which can be practiced as a "one-pot" reaction sequence, without employing PCl.sub.3 or H.sub.3 PO.sub.3. The new intermediate has the structure: ##STR1## where n=1-5.
    Type: Grant
    Filed: September 18, 1990
    Date of Patent: August 13, 1991
    Assignee: Merck & Co., Inc.
    Inventor: Gerard R. Kieczykowski