Patents Represented by Attorney, Agent or Law Firm Charles M. Kinzig
  • Compounds
    Patent number: 6465621
    Abstract: The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 15, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward
  • Triarylimidazoles
    Patent number: 6465493
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R2 and R3 are various substituent groups; and one of X1 and X2 is N or CR′, and the other is NR′ or CHR′ wherein R′ is hydrogen, OH, C1-6alkyl, or C3-7cycloalkyl; or when one of X1 and X2 is N or CR′ then the other may be S or O; and their use as pharmaceuticals.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: October 15, 2002
    Assignee: Smithkline Beecham Corporation
    Inventors: Joelle L. Burgess, James F. Callahan
  • Fibronectin binding proteins
    Patent number: 6461614
    Abstract: The invention provides Fibronectin Binding Protein polypeptides and DNA (RNA) encoding Fibronectin Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Fibronectin Binding Protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: October 8, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: John Edward Hodgson, Martin Karl Russel Burnham
  • Process for preparing eprosartan using regioselective protection of 2,4-disubstituted-imidazole intermediates
    Patent number: 6458963
    Abstract: The present invention relates to a process for preparing eprosartan, an angiotensin II receptor antagonist useful in the treatment of hypertension, congestive heart failure, and renal failure. The process for preparing eprosartan consists of three stages. These stages are: (Stage†1) the regioselective protection of 2-n-butyl-4-formylimidazole; (Stage†2) the reaction between the product from Stage 1 and (2-thienylmethyl)-propanedioic acid, mono-C1-4alkyl ester; and (Stage†3) quaternary salt formation, followed by a basic work-up and an acidification. The efficiency of this synthetic sequence is particularly is particularly useful for the large-scale production of eprosartan.
    Type: Grant
    Filed: August 14, 2001
    Date of Patent: October 1, 2002
    Assignee: SMithKline Beecham Corporation
    Inventors: Richard T. Matsuoka, Peng Liu
  • Vitronectin receptor antagonists
    Patent number: 6458784
    Abstract: Pharmaceutically active benzodiazapine compounds of formula (I) are disclosed. These compounds inhibit the vitronectin receptor and are useful for treatment of osteoporosis.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: October 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Russell Donovan Cousins, Richard McCulloch Keenan, Chet Kwon, William Henry Miller, Irene Nijole Uzinskas
  • Hydroxamic acid derivatives as inhibitors of the production of human CD23 and of the TNF release
    Patent number: 6458779
    Abstract: Compounds of Formula (1) wherein: R is methyl substituted by one to three groups from alkyl, aryl, alkenyl, and alkynyl; n is ) or 1; R1 is arylmethyl or heterocyclylmethyl; R2 is alkyl, alkenyl, cycloalkyl or cycloalkenyl; and R3 is hydrogen, alkyl, alkenyl, alkynyl or aryl; are useful in the treatment of disorders mediated y s-CD23.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: October 1, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Andrew Faller, David Timothy MacPherson, Peter Henry Milner, Jayshree Mistry, John Gerald Ward
  • Macrophage scavenger receptor antagonists
    Patent number: 6458845
    Abstract: Macrophage scavenger receptor antagonists are provided. Methods of treating cardiovascular disease comprising administration of the present compounds are also provided. The present compounds inhibit lipid accumulation within macrophage-derived foam cells.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: October 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Joseph Weinstock, Robert G. Franz, Dimitri E. Gaitanopoulos
  • Vitronectin receptor antagonists
    Patent number: 6458814
    Abstract: Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: October 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Peter J. Manley, William H. Miller
  • Phosphatidylglycerophosphate synthase from Staphylococcus aureus
    Patent number: 6458572
    Abstract: The invention provides Phosphatidylglycerophosphate Synthase polypeptides from Staphylococcus aureus (“pgsA polypeptides”). Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David John Holmes, Chanal Myriam Petit, Christopher Michael Traini, Richard Lloyd Warren
  • Methods of use of quinolone compounds against anaerobic pathogenic bacteria
    Patent number: 6455540
    Abstract: This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against pathogenic bacteria, especially anaerobic pathogens.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: September 24, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Diane M. Citron, Ellie J. C. Goldstein
  • Composition for treating dementia and Alzheimer's disease
    Patent number: 6451343
    Abstract: Controlled release dosage forms useful in the treatment and/or prophylaxis of dementia, including Alzheimer's disease, in mammals, and for enhancing amyloid precursor protein processing along a non-amyloidogenic pathway in patients suffering from, or at risk of developing, Alzeimer's disease.
    Type: Grant
    Filed: August 30, 2000
    Date of Patent: September 17, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Robert Glinecke, William Muldoon, Susan Marie Milosovich, Joseph Sauer, Laurence Rousseau
  • Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
    Patent number: 6452022
    Abstract: This invention relates to a method of preparing a compound type where at least one of R′ or R″ is a carboxyl group (I) by treating a compound of formula (II) with a Group I(a) or Group II(a) metal halide, with an aprotic dipolar amide-based solvent and water.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: September 17, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Kevin Webb, Wilford Mendelson, Jianhao Chen
  • Combined hepatitis and herpesvirus antigen compositions
    Patent number: 6451320
    Abstract: Novel combined vaccine compositions preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in addition one or more of the following: an EBV antigen, a hepatitis A antigen or inactivated attenuated virus, an HPV antigen, a VZV antigen, an HCMV antigen, a Toxoplasma gondii antigen. The vaccine compositions are formulated with an adjuvant which is a preferential stimulator of TH1 cell response such as 3D-MPL and QS21.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: September 17, 2002
    Assignee: SmithKline Beecham Biologicals S.A.
    Inventors: Jean Stephenne, Martine Anne Cecile Wettendorff
  • Beta lactams as antiproliferative agents
    Patent number: 6451785
    Abstract: A method of inhibiting or reducing cell proliferation in a human or mammal is disclosed. This method involves administering to a human or mammal an effective amount of CoA-independent transacylase inhibiting amount of a compound of the formula disclosed in the specification.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: September 17, 2002
    Assignees: SmithKline Beecham Corporation, Wake Forest University
    Inventors: James David Winkler, Floyd Harold Chilton, III
  • EF-Tu
    Patent number: 6451556
    Abstract: The invention provides EF-Tu polypeptides and polynucleotides encoding EF-Tu polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing EF-Tu polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: September 17, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Howard Kallender, Stephanie Van Horn
  • Member of ATP dependent protease family, clpL
    Patent number: 6447773
    Abstract: The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: September 10, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Andrew Fosberry, Elizabeth J Lawlor
  • ribB
    Patent number: 6448036
    Abstract: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: September 10, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, Martin Karl Russell Burnham, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M Pratt, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Judith M Ward, Richard Lloyd Warren
  • Myt1 kinase inhibitors
    Patent number: 6448272
    Abstract: A compound according to Formula (I), hereinbelow: wherein A—B represents a covalent bond or an optionally substituted 1,3 or 1,4 aryl ring selected from the group consisting of: X is independently selected from the group consisting of H, Br, CH3, CN, and NR1R2, wherein R1 and R2 represent hydrogen or C1-4 alkyl; branched or cyclic, optionally containing O or N; and Ar represents optionally substituted phenyl or an optionally substituted 5 or 6 membered heterocylic ring containing one or more heteroatoms selected from N, O and S; provided that when Y is hydrogen, at least one Ar contains a heteroatom selected from N, S and O.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: September 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Maria A. Lago
  • BirA from staphylococcus aureus
    Patent number: 6448038
    Abstract: The invention provides birA polypeptides and polynucleotides encoding birA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing birA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: September 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Howard Kallender, Damien McDevitt, Stephanie Van Horn, Daniel R Sylvester
  • Icon for an electronic display screen
    Patent number: D464061
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: October 8, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Steven R. Frederick