Abstract: The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described.
Type:
Grant
Filed:
May 9, 2008
Date of Patent:
November 9, 2010
Assignee:
Forest Laboratories Holdings Limited
Inventors:
Xiangmin Liao, Haijian Zhu, Andreas Grill
Abstract: Nebivolol has been shown to be beneficial in the treatment of cardiovascular diseases such hypertension, congestive heart failure, arterial stiffness and endothelial dysfunction. The present invention features a pharmaceutical composition comprising nebivolol and at least one other active agent, wherein the at least one other active agent is a cardiovascular agent.
Type:
Grant
Filed:
May 31, 2005
Date of Patent:
September 28, 2010
Assignee:
Forest Laboratories Holdings Limited
Inventors:
Eric Davis, John O'Donnell, Peter Bottini