Patents Represented by Attorney, Agent or Law Firm Charles T. Joyner
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Patent number: 8329272Abstract: The present invention is a structural beam having at least one composite core within a hollow beam of metal or polymeric material, i.e. a jacket, and a layer of elastomeric material between the composite core and the inner walls of the metal or polymeric jacket. This structural beam also may be fitted with brackets or holes at its ends and points along its length to allow attachment to other structural elements. The present beam provides a synergism between the properties of its composite core and the metal or polymeric jacket, and is particularly useful where a high strength to weight ratio is required.Type: GrantFiled: March 18, 2011Date of Patent: December 11, 2012Inventor: Anthony John Cesternino
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Patent number: 8186704Abstract: Taught herein is a trailer having a gooseneck that can be engaged with the fifth wheel of a road tractor, rear truck unit, and a detachable cargo deck connecting the gooseneck with the truck unit. The cargo deck may be detached from the gooseneck and rested on the ground to allow heavy equipment to be loaded onto the cargo deck. The cargo deck can be reattached to the gooseneck, and elevated and locked into any one of three positions, each substantially parallel with the road, by an elevating means in the gooseneck and the truck unit. Thus the trailer of the present invention can be configured to accommodate cargo have a wide range of weight and size.Type: GrantFiled: June 15, 2010Date of Patent: May 29, 2012Inventor: Anthony Cesternino
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Patent number: 6538136Abstract: The present invention provides a novel process for the preparation of substituted piperidine-4-ones useful as intermediates in the preparation of pharmaceuticals.Type: GrantFiled: December 11, 2001Date of Patent: March 25, 2003Assignee: Eli Lilly and CompanyInventors: John Robert Rizzo, Michael Alexander Staszak, Tony Yantao Zhang
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Patent number: 6514976Abstract: Described herein is a compound of the formula wherein Ar′ is a mono or bicyclic aromatic or heteroaromatic radical substituted with one to three substituents selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; R1 is hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio; R2 is phenyl, naphthyl or (C3-C12)cycloalkyl substituted with one or two substituents selected from the group consisting of hydrogen (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; R3 is selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; X is —(C═O)—; or a pharmaceutically acceptable salt racemate, optical isomer or solvatType: GrantFiled: April 30, 2002Date of Patent: February 4, 2003Assignee: Eli Lilly and CompanyInventors: Daniel Timothy Kohlman, Yao-Chang Xu
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Patent number: 6465453Abstract: The present invention provides compounds of formula I and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT1A receptor and antagonizing the 5-HT2A receptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula I.Type: GrantFiled: November 28, 2000Date of Patent: October 15, 2002Assignee: Eli Lilly and CompanyInventors: Kenneth Lee Hauser, Larry Wayne Hertel, Yao-Chang Xu
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Patent number: 6436964Abstract: The present invention provides the compounds of the following formula: Wherein the variables are as defined in the specification and a method for inhibiting the reuptake of seretonin, antagonizing the 5-HT1A receptor and antagonizing the 5-HT2A receptor which comprises administering to a subject in need of such treatment an effective amount of the compound of above formula.Type: GrantFiled: November 28, 2000Date of Patent: August 20, 2002Assignee: Eli Lilly and CompanyInventors: Larry Wayne Hertel, Daniel Timothy Kohlman, Sidney Xi Liang, David Taiwai Wong, Yao-Chang Xu
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Patent number: 6376505Abstract: A class of novel substituted-aryloxy-2-ol-3-(4-spiro-(alkanedioxy)isobenzofuranyl- and phthaloyl-piperidine) derivatives is disclosed useful as 5-HT1A and 5-HT1D&agr; antagonists.Type: GrantFiled: November 22, 1999Date of Patent: April 23, 2002Assignee: Eli Lilly and CompanyInventor: Vincent P. Rocco
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Patent number: 6362351Abstract: The invention is a catalyst, the use of the catalyst and a method of using the catalyst in the formation of a compound with an amide bond. The catalyst is an HOBT derivative having the following formula (1): where R1 is a group bearing a positive charge at pH 5-7; where Y is a bond or a substituted or unsubstituted alkylene chain containing 1-10 carbon atoms and 0-2 heteroatoms selected from the group consisting of N, S and O; and where X is a linker group selected from —CO— or —SO2—. In the method, an amine, a carboxylic acid, an amide coupling agent and a catalyst of formula (1) are reacted for a time sufficient to produce an amide bond between the amine and the carboxylic acid. Thereafter, the compound containing the amide bond is isolated.Type: GrantFiled: February 22, 2001Date of Patent: March 26, 2002Assignee: Eli Lilly and CompanyInventor: William Leonard Scott
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Patent number: 6358958Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.Type: GrantFiled: January 3, 2001Date of Patent: March 19, 2002Assignee: Eli Lilly and CompanyInventors: Daniel Timothy Kohlman, Yao-Chang Xu
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Patent number: 6355674Abstract: A class of novel aminotetralins is disclosed useful as 5-HT1D&agr; agonists.Type: GrantFiled: May 2, 2000Date of Patent: March 12, 2002Assignee: Eli Lilly and CompanyInventors: John M Schaus, Clint D Walker, Yao-Chang Xu
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Patent number: 6353008Abstract: The present invention provides the compounds of the following formula (I): and a method for inhibiting the reuptake of seretonin, antagonizing the 5-HT1A receptor and antagonizing the 5-HT2A receptor which comprises administering to a subject in need of such treatment an effective amount of formula (I).Type: GrantFiled: November 28, 2000Date of Patent: March 5, 2002Assignee: Eli Lilly and CompanyInventors: Larry Wayne Hertel, Yao-Chang Xu
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Patent number: 6342498Abstract: Anylpiperazines of formula (1) useful as serotonin reuptake inhibitors and 5-HT1D&agr; receptor antagonists are disclosed herein: wherein R1 and R2 are each independently hydrogen, halo, —(C1-C6)alkyl or —(C1-C6)alkoxy; R3 is hydrogen or —(C1-C6)alkyl; Y is —CO— or —CH2—; Z is —NH—, —N(COR)— or —CH2— where R is —(C1-C6)alkyl or —(C3-C8)cycloalkyl; represents a double or single bond; n and m are an each independently integer from 1 to 3, both inclusive; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 31, 2000Date of Patent: January 29, 2002Assignee: Eli Lilly and CompanyInventors: Clint Duane Walker, David Taiwai Wong, Yao-Chang Xu
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Patent number: 6319187Abstract: The invention is a catalyst, the use of the catalyst and a method of using the catalyst in the formation of a compound with an amide bond. The catalyst is an HOBT derivative having the following formula (1): where R1 is a group bearing a positive charge at pH 5-7; where Y is a bond or a substituted or unsubstituted alkylene chain containing 1-10 carbon atoms and 0-2 heteroatoms selected from the group consisting of N, S, an O; and where X is a linker group selected from —CO— or —SO2—. In the method, an amine, a carboxylic acid, an amide coupling agent and a catalyst of formula (1) are reacted for a time sufficient to produce an amide bond between the amine and the carboxylic acid. Thereafter, the compound containing the amide bond is isolated.Type: GrantFiled: August 8, 2000Date of Patent: November 20, 2001Assignee: Eli Lilly and CompanyInventor: William Leonard Scott
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Patent number: 6080587Abstract: Methods for rapidly generating large rationally designed libraries of structurally-diverse small molecular weight compounds using a multicombinatorial approach.Type: GrantFiled: January 23, 1998Date of Patent: June 27, 2000Assignee: Eli Lilly and CompanyInventors: Michael Raymond Pavia, Harold Vernon Meyers
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Patent number: 5942387Abstract: This invention relates to a novel solid phase process for the preparation of thiophene combinatorial libraries. These libraries have use for drug discovery and are used to form wellplate components of novel assay kits.Type: GrantFiled: August 25, 1997Date of Patent: August 24, 1999Assignee: Eli Lilly and CompanyInventor: Sean Patrick Hollinshead
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Patent number: 5457098Abstract: There are disclosed preparation and compounds of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or lower alkyl or taken together are a --CH.sub.2 -- group to form a cyclopropane ring.X is ##STR2## wherein R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are hydrogen or alkyl,p and q are independently either 0 or 1;R.sup.3 is alkyl, alkenyl, cycloalkyl, alkoxy, thiopyridyl, adamantyl, --NR.sup.9 R.sup.10 or --Ar--NR.sup.9 R.sup.10 whereinR.sup.9 and R.sup.10 are hydrogen or alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, adamantyl, aryl, benzyl, diphenylmethyl, norbornyl, or taken together with the nitrogen to form 4 to 8 atom heterocyclic group, ##STR3## optionally substituted with alkyl groups; Ar is aromaticR.sup.4 is hydrogen or methyl;Z is --O--, --NH--, --N(lower alkyl), --S--, --SO--, --SO.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, CO, CO.sub.2, O.sub.2 C, --N.dbd.N--, --CH.dbd.N--, or --N.dbd.CH--,and n and m are 0, 1 or 2.Type: GrantFiled: January 28, 1994Date of Patent: October 10, 1995Assignee: Glaxo Inc.Inventors: Stephen V. Frye, David Middlemiss, Francis G. Fang
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Patent number: 5407687Abstract: The present invention comprises a bi-layer, pharmaceutical tablet having one layer formulated for the immediate release (IR) of ranitidine and a second layer formulated for sustained release (SR) of ranitidine with the ratio of ranitidine in the IR layer to that in the SR in the range of from about 30:70 to about 60:40.Type: GrantFiled: February 22, 1994Date of Patent: April 18, 1995Assignee: Glaxo Inc.Inventors: Mark D. Coffin, Alan F. Parr
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Patent number: 5342947Abstract: The present invention relates to the synthesis of water soluble, camptothecin derivatives of formula (I), ##STR1## wherein: n represents the integer 1 or 2;R.sup.1 represents independently, hydrogen, lower alkyl, (C.sub.3-7)cycloalkyl, (C.sub.3-7)cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, lower alkoxy lower alkyl; andR.sup.2 represents hydrogen andthe pharmaceutically acceptable salts thereof.Type: GrantFiled: October 9, 1992Date of Patent: August 30, 1994Assignee: Glaxo Inc.Inventors: Karen Lackey, Daniel D. Sternbach
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Patent number: 5318976Abstract: The present invention relates to certain substituted tetracyclic fused quinoline derivatives of formula (I): ##STR1## wherein: R.sup.1 is hydrogen, hydroxy, fluoro, chloro, bromo, iodo, methoxy or amino;R.sup.2 is hydrogen, hydroxy, methoxy or amino;R.sup.3 is hydrogen, hydroxy, methoxy, methoxymethoxy, amino, --OCONH.sub.2, [2(5H)-3,4-dihydro-3-oxyfuranone], 2-hydroxyethoxy, 2-aminoethoxy, 3-hydroxypropoxy or 3-aminopropoxy; or taken together with R.sup.2 or R.sup.4, methylenedioxy or ethylenedioxy;R.sup.4 is hydrogen, hydroxy or amino;Z is --CH.sub.2 --, --O-- or --NH--; anda) X.sup.1 is hydrogen;X.sup.2 is hydrogen, hydroxy, fluoro, chloro, bromo, iodo or methoxy; andX.sup.3 is hydrogen or hydroxy; orb) X.sup.2 taken together with X.sup.3 is methylenedioxy or ethylenedioxy, and X.sup.1 is hydrogenor a pharmaceutically acceptable salt thereof provided that:i) at least one of R.sup.1 through R.sup.4 is other than hydrogen.Type: GrantFiled: August 18, 1992Date of Patent: June 7, 1994Assignee: Glaxo Inc.Inventors: Michael J. Luzzi, Jeffrey Besterman, Michael G. Evans, M. Ross Johnson, Milana Dezube, Salvatore Profeta, Jr.
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Patent number: 5318183Abstract: A bottle having an inserted tube in its neck to effectively reduce its interior volume and allow a large surface area for the bottle exterior, e.g. for supporting a large label or to allow oversized print, with a relatively small interior volume, e.g. to prevent abrasions caused by the interior contents moving excessively against each other.Type: GrantFiled: November 4, 1992Date of Patent: June 7, 1994Assignee: Glaxo, Inc.Inventors: Donald B. Cohen, Norris W. Matthews