Abstract: This invention provides a method to enhance an immune response of nucleic acid vaccination by simultaneous administration of a polynucleotide and a polypeptide of interest.
Type:
Grant
Filed:
June 12, 2000
Date of Patent:
December 31, 2002
Assignee:
SmithKline Beecham Biologicals, S.A.
Inventors:
Wilfried Dalemans, Marcelle Van Mechelen, Claudine Bruck, Martin Friede
Abstract: AXOR34 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR34 polypeptides and polynucleotides in diagnostic assays. Further disclosed are screening assays to identify agonists and antagonists of the interaction between AXOR34 and its ligands, NmU-8, NmU-25, and NmU-23.