Abstract: A pure Factor I protein essentially free of infectious virus. Factor B and C3. The protein is derived from plasma and pasteurized by heating to a temperature of 50.degree. to 65.degree. C. for 0.5 to 100 hours in the presence of one or more stabilizers for Factor 1. Preparations containing the protein are useful in the treatment of Factor I deficiency and autoimmune diseases.

Abstract: This invention relates to novel aprotinin analogues having a selected inhibition profile against serine proteases.

Abstract: Good deinking of waste paper can be obtained at high consistency by first pulping at high pH, then lowering the pH, adding alkaline cellulase and letting the cellulase act during continued pulping and/or maceration. The improved deinking results in higher whiteness and better cleanliness (fewer ink particles) in paper made from the treated pulp after separation of ink particles. This cellulase treatment results in better operation of certain equipment such as thickeners and in better drainage of the pulp during paper making.

Abstract: In a method for effecting an increased expression in serum-free medium of recombinant proteins in a host cell being able to express said protein said host is cultured in a serum-free medium comprising an egg yolk fraction being free of lipoprotein and lipids so as to express said protein. Also the use of an egg yolk fraction being free of lipoprotein and lipids for increasing the expression of recombinant proteins in a host cell being able to express said protein in a serum-free cell growth medium is disclosed.

Abstract: The invention provides crystalline Tiagabine hydrochloride monohydrate, process for its preparation, compositions containing the same and its therapeutic use as anti-epileptic agent.

Abstract: A particulate immobilized microbial lipase is prepared by adsorption of lipase to macroporous inorganic carrier particles having specific characteristics. The carrier particles contain at least 65% silica or silicates, an excess of 90% particles having a size between 100 and 1000 .mu.m and an excess of 80% pores exhibiting a diameter of between 12 and 45 times the diameter of a lipase molecule. The lipase is adsorbed to the carrier particles by contacting the particles with an aqueous solution of lipase and drying the particles to a water content between 1 and 20%. The lipase is preferably a thermostable lipase from a Humicola species, Candida antarctica or Rhizomucor miehei. The particulate immobilized lipase is cheap to produce, exhibits a high specific activity, and can be used for interesterification of fats, hydrolysis of fats or synthesis of fatty acid esters.

Abstract: Synthetic leaders for effective secretion of proteins in yeast are provided. Also provided are replicable yeast vectors containing a DNA-sequence encoding the synthetic leader positioned upstream to a DNA-sequence encoding the desired product and operably connected with promoter and signal sequences. There are also provided yeast strains transformed with such vectors and a method for producing proteins by means of the transformed yeast strains.

Abstract: This invention relates to mutants or variants of Bacillus thuringiensis producing high amounts of active delta-endotoxins. The delta-endotoxins produced by the mutant or variant B. thuringiensis will have an activity directed towards the same pest insects as its parent B. thuringiensis delta-endotoxins, such as against lepidopterans (mutants from B. thuringiensis subsp. kurstaki or subsp. aizawai), dipterans (mutants from B. thuringiensis subsp. israelensis) or coleopterans (mutants from B. thuringiensis subsp. tenebrionis).

Abstract: The invention relates to novel substituted 2-imidazolines (I) having a lowering effect on blood glucose in mammals, to their preparation, to pharmaceutical compostions containing them and to their use.

Abstract: A process for expression of a protein product in Aspergillus is disclosed. The process comprises transforming an Aspergillus strain with a vector system comprising DNA-sequences encoding a promoter including upstream activating sequences derived from an A. niger amylase, a suitable marker for selection of transformants, and a DNA-sequence encoding the desired protein product. The process enables industrial production of many different polypeptides and proteins in Aspergillus, preferably A. niger. Examples of such products are chymosin or prochymosin and other rennets, proteases, lipases and amylases. Also disclosed is an effective promoter for expression of a protein in Aspergillus, preferably Aspergillus niger being derived from a gene encoding an A. niger amylase. The A. niger amylases are the neutral and acid stable .alpha.-amylases and a new amylase not so far described and designated XA amylase. Also disclosed is the novel amylase from A. niger XA amylase.

Abstract: Non-surgically correctable infertility or sub-fertility in adult men having poor semen quality is treated with injections of human Growth Hormone (hGH) in daily doses of 1-10 IU/m.sup.2 or in doses in combination with gonadotrophins. Increase in total semen volume and total sperm number per ejaculate up to normal figures is obtained.