Patents Represented by Attorney Choate, Hall & Stewart LLP
-
Patent number: 8350073Abstract: The present invention provides methods for the synthesis of catalysts and precursors thereof. Methods of the invention may comprise combining a catalyst precursor and at least one ligand to generate a catalytically active species, often under mild conditions and in high yields. In some cases, a wide variety of catalysts may be synthesized from a single catalyst precursor. Methods of the invention may also include the preparation of catalysts which, under reaction conditions known in the art, may have been difficult or impossible to prepare and/or isolate due to, for example, steric crowding at the metal center. The present invention also provides catalyst compositions, and precursors thereof, which may be useful in various chemical reactions including olefin metathesis. In some cases, methods of the invention may reduce the number of synthetic and purification steps required to produce catalysts and/or other reaction products, as well as reducing time, cost, and waste production.Type: GrantFiled: February 23, 2011Date of Patent: January 8, 2013Assignee: Massachusetts Institute of TechnologyInventors: Adam S. Hock, Richard R. Schrock
-
Patent number: 8349356Abstract: The present invention provides hemostatic compositions comprising components of the flowers of pharmaceutical chamomile (Chamomilla recutita) and the leaves of dioecious nettle (Urtica dioica). Further inclusion of a biocompatible polymeric base, particularly an alignate, generates a composition with excellent and broad spectrum hemostatic capabilities, with concurrent antiseptic and anti-inflammatory properties. The invention further provides methods of using the inventive compositions in to reduce or stop bleeding, as well as a variety of apparatuses useful in hemostatic contexts that incorporate the inventive compositions. In one particular embodiment, the invention provides hemostatic dressings in which a polymeric layer incorporating chamomile and nettle components is applied to a textile or fabric material, for example a non-woven viscose.Type: GrantFiled: September 23, 2011Date of Patent: January 8, 2013Inventors: Natalia Dmitrievna Oltarshevskaya, Larisa Borisovna Savilova, German Evseevich Krichevsky
-
Patent number: 8350045Abstract: A process for preparation of E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene of Formula-I, and acid addition salts thereof, said process comprising; dehydrating 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinopropan-1-ol of Formula III followed by adding a base solution to obtain a mixture of E and Z isomers of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene, and washing said mixture of E and Z isomers of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene with water to dissolve Z isomer and to obtain E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene of Formula I, which is substantially free from Z isomer.Type: GrantFiled: December 16, 2008Date of Patent: January 8, 2013Assignee: Hikal LimitedInventors: Rajender Pershad Gupta, Veerabhadra Swamy Hiremath, Raghavendra Arekal Vasanna, Vasantha Gowda Nekkilar
-
Patent number: 8343751Abstract: The present invention relates to the use of F4+ non-pathogenic Escherichia coli strains to promote growth in an animal. The present invention also relates to the use of such strains to homogenize growth among a herd of animals. More specifically, the animal(s) of interest in the present invention are those wherein growth promotion or growth homogenization are desired goals, such as animals reared for meat production. The present invention further relates to a method for promoting growth of an animal as well as a method for homogenizing growth among a herd of animals.Type: GrantFiled: July 8, 2011Date of Patent: January 1, 2013Assignee: Valorisation—Recherche, Limited PartnershipInventors: Eric Nadeau, John Morris Fairbrother
-
Patent number: 8338439Abstract: The present invention provides 2,4-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same. In some embodiments, the present invention provides a compound of formula I-a or I-b: wherein each of Ring A, Ring B, W1, W2, Ry, Rv, Rx, m, p, and R1 is described herein.Type: GrantFiled: December 29, 2009Date of Patent: December 25, 2012Assignee: Celgene Avilomics Research, Inc.Inventors: Juswinder Singh, Russell Petter, Richland Wayne Tester, Arthur F. Kluge, Hormoz Mazdiyasni, William Frederick Westlin, III, Deqiang Niu, Lixin Qiao
-
Patent number: 8338088Abstract: The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.Type: GrantFiled: April 15, 2008Date of Patent: December 25, 2012Assignee: Momenta Pharmaceuticals, Inc.Inventors: Brian Edward Collins, Carlos J. Bosques, Xiangping Zhu, Dorota A. Bulik, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Venkataraman
-
Patent number: 8329901Abstract: The present invention provides 4,6-disubstituted pyrimidine compound useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.Type: GrantFiled: February 1, 2011Date of Patent: December 11, 2012Assignee: Celgene Avilomics Research, Inc.Inventors: Juswinder Singh, Shomir Ghosh, Arthur F. Kluge, Russell C. Petter, Richland W. Tester
-
Patent number: 8329455Abstract: This invention relates generally to systems and methods for digestion of solid waste that simplify solids handling. In certain embodiments, anaerobic methane extraction takes place for a period of time (e.g., from 1 to 4 weeks), after which an aerobic composting process begins in the same chamber. The organic waste remains in place and oxygen (e.g., in air) is forced into the chamber for an additional period of time (e.g., from 2 to 4 weeks). At the conclusion of the aerobic phase, the process yields a rough compost product that is stable and pathogen free. The rough compost can be further processed and blended to create high value engineered soils.Type: GrantFiled: September 6, 2011Date of Patent: December 11, 2012Assignee: Aikan North America, Inc.Inventor: Christian B. Christensen
-
Patent number: 8323971Abstract: This invention relates to the culture of pluripotent cells in a fully humanised chemically defined medium. Cells may be cultured over a prolonged period of time without losing their pluripotent status or may be controllably induced to differentiate into progenitor cells of the three primary germ layers by the addition of differentiation factors, for example differentiation factors which modulate one or more of the Activin/Nodal, FGF, Wnt or BMP signalling pathways.Type: GrantFiled: November 9, 2007Date of Patent: December 4, 2012Assignee: Cambridge Enterprise LimitedInventors: Roger Pedersen, Ludovic Vallier
-
Patent number: 8322532Abstract: Packaging device (10, 10?, 10?) for packaging at least one object (12, 12?, 12?), that is essentially flat, in particular a valuable technical object, such as a lithium-ion cell, including: a bottom plate (14) having at least one first side rim (42), which is linear in regard to at least a part thereof, and at least one first cover plate (20) having at least one first side rim (46) which is linear in regard to at least one part thereof, which is hingeably linked to the first side rim (42) of the bottom plate (14) such that the cover plate (20) can be hinged between a closed position in which the cover plate at least partially covers the bottom plate, and an open position in which the cover plate is not opposite to the bottom plate, characterized in that the bottom plate (14) or the at least one cover plate (20) comprises on one side a cushioning layer (16, respectively 22), wherein the cushioned side faces the object (12, 12?, 12?) when said object is in the packaging and the at least one cover plate (20) isType: GrantFiled: October 23, 2009Date of Patent: December 4, 2012Inventors: Tim Schafer, Andreas Gutsch, Gunter Eichinger, Claus-Rupert Hohenthanner, Christian Junker, Magnus Mickel, Heike Schone
-
Patent number: 8324284Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis, wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein.Type: GrantFiled: May 12, 2011Date of Patent: December 4, 2012Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Samuel J. Danishefsky, Christoph Gaul, Jon T. Njardarson
-
Patent number: 8318206Abstract: The present invention provides a particle aggregate comprising particles linked to other particles via linkers that are capable of being cleaved by an enzyme. The particles may be linked directly to other particles by the linkers or may be linked indirectly by means of a binding moiety. The invention also provides a particle coupled to a binding moiety via a linker that can be cleaved by an enzyme. The present invention may be used in diagnosing a disease or condition associated with the enzyme, or may be used to treat such a disease or condition whereby the drug is retained in the particle aggregate until the linkers are cleaved by the enzyme.Type: GrantFiled: November 29, 2006Date of Patent: November 27, 2012Assignee: Imperial Innovations LimitedInventors: Molly M. Stevens, Rein Ulijn, Anna Sague Laromaine, Liling Koh
-
Patent number: 8313756Abstract: Urea compositions useful for treatment of dermatological conditions. The compositions may include greater than about 50 wt-% urea, and methods of making such compositions are provided.Type: GrantFiled: September 16, 2005Date of Patent: November 20, 2012Assignee: Fougera Pharmaceuticals, Inc.Inventors: Ralph N. Landau, Dale R. Sanson, Amir Kamyar Jahani
-
Patent number: 8313894Abstract: Methods and compositions for identifying antigens of human lymphocytes are provided herein.Type: GrantFiled: July 1, 2009Date of Patent: November 20, 2012Assignee: Genocea Biosciences, Inc.Inventors: Jessica Flechtner, Todd Gierahn
-
Patent number: 8309685Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.Type: GrantFiled: July 2, 2009Date of Patent: November 13, 2012Assignee: Celgene Avilomics Research, Inc.Inventors: Russell C. Petter, Juswinder Singh, Arthur F. Kluge, Deqiang Niu, Lixin Qiao, Shomir Ghosh
-
Patent number: 8309653Abstract: Water-based coatings having writable-erasable surfaces are provided. The coatings have many desirable attributes. For example, the coatings cure under ambient conditions, have low or no VOC emissions during and upon curing, and have reduced tendency to form ghost images, even after prolonged normal use.Type: GrantFiled: January 9, 2009Date of Patent: November 13, 2012Assignee: IdeaPaint, Inc.Inventors: John Goscha, Martin Douglas Donbrosky, Jr.
-
Patent number: 8312505Abstract: An electronic card connector is used to connect an electronic card to an electronic device, such as a level-shifting device. The electronic card connector includes an insert slot unit and a switch unit. The insert slot unit is adapted for insertion of the electronic card and is provided with a power signal terminal for providing electric power to the electronic card that is inserted into the insert slot unit. The 10 switch unit is disposed in the insert slot unit, is operable to establish electrical connection between the power signal terminal and a first power source when the electronic card inserted into the insert slot unit does not actuate the switch unit, and is further operable to establish electrical connection between the power signal terminal and a second power source when the electronic card inserted into the insert slot unit actuates the switch unit.Type: GrantFiled: December 29, 2009Date of Patent: November 13, 2012Assignee: Wistron CorporationInventors: Pi-Chang Chiu, Kuo-Hua Chen
-
Patent number: 8309570Abstract: Central neuropathic pain is treated with an analgesic composition that consists essentially of an N-methyl-D-aspartate (NMDA) receptor antagonist. In one embodiment, the invention includes chronic administration of the (NMDA) receptor antagonist. In another embodiment, the invention is use of an NMDA receptor antagonist or component thereof for the manufacture of a medicament than includes an analgesic component that consists essentially of an NMDA receptor antagonist for the chronic treatment of central neuropathic pain.Type: GrantFiled: June 7, 2001Date of Patent: November 13, 2012Assignee: Analgesic Neuropharmaceuticals, LLCInventor: Christine Nai-Mei Sang
-
Patent number: 8304250Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.Type: GrantFiled: April 15, 2008Date of Patent: November 6, 2012Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
-
Patent number: RE43823Abstract: Compositions are provided that comprise antibody against coreceptors for human immunodeficiency virus such as CCR5 and CXCR4. In particular, monoclonal human antibodies against human CCR5 are provided that bind to CCR5 with high affinity and are capable of inhibiting HIV infection at low concentrations. The antibodies can be used as prophylactics or therapeutics to prevent and treat HIV infection, for screening drugs, and for diagnosing diseases or conditions associated with interactions with HIV coreceptors.Type: GrantFiled: November 18, 2011Date of Patent: November 20, 2012Assignee: Genetastix CorporationInventors: Shaobing Hua, Michelle Haynes Pauling, Li Zhu