Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

Abstract: There is described novel organo-platinum luminophores comprising a complex of formula I: The luminophores have application as the emissive component in organic light emitting diodes.

Abstract: The present disclosure is directed to a method of approximating prices in a private property market. First, REIT return data is compiled from each REIT of a plurality of REITs at a predetermined frequency. Then, the REIT return data is processed according to exposures to each of a plurality of target characteristics to obtain coefficients reflecting each REIT's weight in an index. Then, an index is generated according to the REITs, the obtained coefficients, and the weights. Finally, a second index is derived from the generated index that approximates prices in the private property market.

Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.

Abstract: A run-flat support assembly for a wheel rim of a pneumatic tired wheel and method for use of the same are disclosed. In one embodiment, a tubular support structure is positioned in a tire cavity of the pneumatic tired wheel and coupled to the wheel rim to turn concurrently with an axis of rotation of the wheel rim. A skeletal structure is disposed within the tubular support structure. Circumferentially spaced linkages are displaceably secured to respective mounting races of a body of the skeletal structure. Each of the circumferentially spaced linkages is adapted to plastically fail at a pre-determined moment load in a run-flat condition, thereby pivoting relative to the respective mounting race.

Abstract: A composite nanoparticle comprising a nanoparticle confined within a cross-linked collapsed polyelectrolyte polymer wherein the nanoparticle comprises a charged organic ion.

Abstract: Preparation and deposition of supercooled, electron-doped, water-cluster clathrate nanoparticles in confined geometries and on substrates from proprietary nanoemulsions is described. The compositions can yield high-Tc superconductors, e.g., in the vicinity of ?43 deg C., useful for SQUID devices in electronic and magnetic application. In certain embodiments, the water-cluster clathrates are formed in nanoemulsions.

Abstract: The invention provides methods and systems for manufacturing low-acid polyalkylene terephthalate, for example, polybutylene terephthalate (PBT). The invention also provides methods and systems for preparing macrocyclic polyester oligomer (MPO) from low-acid polyalkylene terephthalate. Finally, the invention provides methods and systems for preparing MPO via reaction of a diol and a dialkyl ester in an organic solvent to form non-isolated, low-acid polyalkylene terephthalate which undergoes cyclization (depolymerization) to form MPO.

Abstract: In various embodiments, the invention provides a system for heating a liquid, such as, for example, water, comprising a plurality of liquid heaters, the inlets and outlets of which are respectively connected in a parallel flow relationship by respective manifolds, and configured to provide liquid having a temperature of greater than about 90 degrees Fahrenheit at a flow rate of greater than about 10 gallons per minute. In various embodiments, the present invention provides an electric tankless liquid heater system capable of delivering hot liquids, and in particular water, at even higher flow rates and or temperatures, including, but not limited to, flow rates greater than about: (1) 12 gpm; (2) 18 gpm; (3) 20 gpm; and (5) 20 gpm; and/or temperatures of greater than about: (1) 100° F.; (2) 120° F.; (3) 140° F.; and (4) 180° F.

Abstract: Poly(propylene carbonates) are prepared from propylene oxide and CO2 with less than 10% cyclic propylene carbonate by product using cobalt based catalysts of structure preferably in combination with salt cocatalyst, very preferably cocatalyst where the cation is PPN+ and the anion is Cl? or OBzF5?. Novel products include poly(propylene carbonates) having a stereoregularity greater than 90% and/or a regioregularity of greater than 90%.

Abstract: A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.

Abstract: As described herein, the present invention provides methods for preparing compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.

Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.

Abstract: A method for producing a composite nanoparticle, including the steps of: changing the conformation of a dissolved polyelectrolyte polymer from a first extended conformation to a more compact conformation by changing a solution condition so that at least a portion of the polyelectrolyte polymer is associated with a precursor moiety to form a composite precursor moiety with a mean diameter in the range between about 1 nm and about 100 nm; and cross-linking the polyelectrolyte polymer of the composite precursor moiety to form a composite nanoparticle.

Abstract: The present disclosure provides, in part, a method for removing a catalyst from a product of catalyzed aliphatic polycarbonate polymerization reaction.

Abstract: The present application is directed towards systems and methods for efficient installation of optical and electrical cable in watercraft. A manufacturer may terminate one end of a cable in a location removed from the watercraft, allowing use of automated cable termination machines for efficiency and consistency of terminations. The single-terminated cable may then be brought to the watercraft and installed by pulling or routing the unterminated end through ductwork and pipes, watertight bulkhead throughways, and cable trays and ladders as necessary, prior to termination. Accordingly, more difficult and expensive on-site labor is reduced, and reliability is greatly increased. Furthermore, many cable tests that require termination but cannot be executed post-installation can be performed prior to installation, to ensure that at least the first termination, performed off-site, is error-free, reducing later troubleshooting and further increasing installation efficiency.

Abstract: Method and apparatus for preventing heart rhythm disturbances by recording cardiac electrical activity, measuring beat-to-beat variability in the morphology of electrocardiographic waveforms, and using the measured beat-to-beat variability to control the delivery of electrical impulses to the heart during the absolute refractory period.

Abstract: The present invention provides, among other things, compositions and methods suitable for the treatment of hyperphosphatemia based on phosphate-binding magnesium salts. In some embodiments, the present invention provides compositions and methods suitable for the treatment of hyperphosphatemia based on the combination of phosphate-binding magnesium and calcium salts.