Patents Represented by Attorney Christine C. Dike, Bronstein, Roberts & Cushman, LLP O'Day
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Patent number: 6110891Abstract: This invention provides methods for: the control of mucosal cell proliferation; the reduction and/or treatment of damage caused by a cell-damaging agent; and for the reduction and/or treatment of a metabolic disorder.The methods comprise administering to an individual in need of control or reduction and/or treatment on effective amount of a lectin.The invention takes advantageous of the protective and repair capabilities of lectins. It is particularly useful in the prevention and treatment of animals undergoing radiotherapy and/or chemotherapy for cancer.Type: GrantFiled: August 28, 1998Date of Patent: August 29, 2000Assignee: Alizyme Therapeutics Ltd.Inventors: Arpad Janos Pusztai, Zsuzsanna Magdolna Bardocz, Richard Michael John Palmer, Neil William Fish, Gyorgy J. Koteles
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Patent number: 6087346Abstract: The invention relates to methods for the treatment of central nervous system disorders, neurological disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment. The invention further relates to novel sigma receptor ligands having high binding to the sigma receptor and pharmaceutical compositions thereof.Type: GrantFiled: February 21, 1996Date of Patent: July 11, 2000Assignees: Cambridge Neuroscience, Inc., Virginia Commonwealth UniversityInventors: Richard A. Glennon, James B. Fischer
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Patent number: 6076572Abstract: The present invention provides an apparatus that lifts, secures, splits and/or crushes tree stumps or other materials, particularly wooden or metal materials and other materials that may be present at an excavation site. The apparatus is characterized in part by a two pivot point design. A first pivot point allows for the pivotable operation of an engaging unit which grabs and lifts the tree stump. The engaging unit further acts a durable and secure support member for the tree stump during the splitting and crushing process. The second pivot point allows for the pivotable operation of a cutting device which facilitates splitting and crushing of the stumps.Type: GrantFiled: February 16, 1999Date of Patent: June 20, 2000Inventor: Douglas B. Cook
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Patent number: 6065288Abstract: The hydraulic control system disclosed herein employs a pair of combination poppet/spool valves to control the operation of a hydraulic cylinder driven from a bidirectional pump. Flow introduced through the source port of one valve lifts the poppet of the other valve on its way to one side of the cylinder which in turn opens a throttling port to modulate return flow from the other side of the cylinder.Type: GrantFiled: August 10, 1998Date of Patent: May 23, 2000Inventor: J. Robert Glomeau
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Patent number: 6066398Abstract: The present invention relates to a polycarbonate molding material for optical discs, comprising pellets which comprises a polycarbonate with a viscosity-average molecular weight of 10,000 to 18,000;has an average length of 2.5 to 3.5 mm; andhas an average longer diameter of the sectional ellipse of 2.60 to 3.2 mm,not less than 70% of said pellets having a length falling within the range of .+-.0.08 mm from the mean value of length and a longer diameter falling within the range of .+-.0.12 mm from the mean value of longer diameter.Type: GrantFiled: July 20, 1998Date of Patent: May 23, 2000Assignee: Mitsubishi Engineering-Plastics CorporationInventor: Masaya Ueda
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Patent number: 6050512Abstract: A clutch bearing for preventing reverse rotation of a bushing received within the bearing includes a housing having a plurality of recesses, each recess having a shallow portion and a deep portion, an insert member disposed within the housing and having a plurality of retaining bars, a plurality of rollers each being received between two adjacent retaining bars, a clutch coupled to the insert member and operable to either dispose the rollers near the respective deep portions of the recesses for rotation in clockwise and counter-clockwise directions or dispose the rollers near the respective shallow portions of the recesses for preventing rotation in one direction.Type: GrantFiled: June 9, 1998Date of Patent: April 18, 2000Assignee: Shin A Sports Co., Ltd.Inventor: Soo Jin Jung
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Patent number: 6019211Abstract: A conveyor having a plurality of spaced rollers mounted between a pair of elongated horizontal frame members for supporting an article and enabling the article to be conveyed longitudinally of the frame members. The conveyor has a workstation formed by a plurality of interrupter strips extending in the spaces between rollers. Each interrupter strip has a plurality of lifting pads which are selectively movable between a lower position in which the upper surface of the pads are below the tops of the rollers and an upper position in which the upper surface of the pads are above the tops of the rollers for supporting the article and frictionally engaging the article to maintain the article in a stable position above the strips. The interrupter strips also have a plurality of balls mounted for omnidirectional rotation on the interrupter strip.Type: GrantFiled: January 17, 1997Date of Patent: February 1, 2000Assignee: Omtec CorporationInventor: Camillo Masciarelli, Jr.
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Patent number: 5914149Abstract: A transparent liquid food of the present invention contains a sucrose fatty acid ester which has a constitutive fatty acid, which is a saturated or unsaturated fatty acid having 8 to 22 carbon atoms in aliphatic carbon chain thereof and having a monoester content of not less than 93% by weight, in which no cloudiness and precipitation in the transparent liquid foods, i. e., transparent beverages and foods arise when the sucrose fatty acid ester is added thereto.Type: GrantFiled: June 25, 1997Date of Patent: June 22, 1999Assignee: Mitsubishi-Kagaku Foods CorporationInventor: Masaaki Tomida
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Patent number: 5892126Abstract: Disclosed is a process for preparing 4-fluoro-3-trifluoromethylphenol from 4-fluoro-3-trifluoromethylaniline, which comprises the steps of (1) using about 1 to 20 parts by weight of water based on 1 part by weight of 4-fluoro-3-trifluoromethylaniline in the presence of sulfuric acid to obtain 4-fluoro-3-trifluoromethylaniline sulfate; (2) subjecting the obtained 4-fluoro-3-trifluoromethylaniline sulfate to a diazotization reaction by using a diazotizing agent to obtain an aqueous solution containing about 8 to 25% by weight of a 4-fluoro-3-trifluoromethylbenzene-diazonium salt where a sulfuric acid concentration after diazotization is about 30 to 70% by weight in terms of the amount of sulfuric acid added, and the amount of water used is about 1 to 20 parts by weight based on 1 part by weight of 4-fluoro-3-trifluoromethylaniline; and (3) hydrolyzing the obtained 4-fluoro-3-trifluoromethylbenzenediazonium salt where a sulfuric acid concentration is about 30 to 70% by weight in terms of the amount of sulfuric aType: GrantFiled: November 13, 1997Date of Patent: April 6, 1999Assignee: Ube Industries, Ltd.Inventors: Katsumasa Harada, Akio Matsushita, Yasuhiro Kawachi
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Patent number: 5852538Abstract: A power element driving circuit is provided with an abnormality detecting circuit which detects an occurrence of abnormality in an IGBT (power element) or a short-circuit load based on a collector voltage of the IGBT, and controls a gate voltage control circuit so as to gradually reduce a gate voltage of the IGBT. According to the described arrangement, the IGBT can be protected from breakdown caused by short-circuit current increased by itself due to an inverse current from the load. Moreover, since an occurrence of abnormality in the IGBT is detected after starting up the IGBT, the rise time for the IGBT can be reduced, thereby preventing the thermal breakdown or power loss which may occur when a long rise time is required.Type: GrantFiled: July 14, 1997Date of Patent: December 22, 1998Assignee: Sharp Kabushiki KaishaInventor: Yoshitugu Masui
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Patent number: 5847785Abstract: A liquid crystal display device includes a large-panel prepared by connecting a plurality of liquid crystal panels side to side on a large substrate, each liquid crystal panel being composed of a TFT substrate and a CF substrate. The TFT substrate and the CF substrate are connected by a combined use of a first seal material of a photo-setting resin formed along connecting sides between the liquid crystal panels and a second seal material made of a thermosetting resin formed along other sides than the connecting sides. As a result, a hardening inferior of the seal material as well as a display inferior of the liquid crystal panel due to the seal material can be prevented.Type: GrantFiled: April 8, 1998Date of Patent: December 8, 1998Assignee: Sharp Kabushiki KaishaInventor: Yoshihiro Izumi