Patents Represented by Attorney, Agent or Law Firm Christine Gritzmacher
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Patent number: 8293885Abstract: The invention includes compositions and methods of detection of Bacillus anthracis that use oligonucleotide probes specific for genetic material contained in the pXO1 and pXO2 plasmids in nucleic acid hybridization reactions. Embodiments of the method may include additional probes specific for other gene sequences to distinguish B. anthracis from other bacterial species present in a sample or to provide an indication that the assay was performed properly even when no Bacillus sequence is detected.Type: GrantFiled: October 31, 2007Date of Patent: October 23, 2012Assignee: Gen-Probe IncorporatedInventors: Sylvia A. Norman, Jennifer J. Bungo, James J. Hogan, William G. Weisburg
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Patent number: 8198027Abstract: Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specifically to a target sequence that is amplified and a universal (U) sequence that is introduced into the sequence that is amplified, by using a primer for the universal sequence. Methods of nucleic acid amplification in vitro are disclosed that use one or more TSU oligonucleotides to attached a U sequence to a target nucleic acid in a target capture step and then use a primer for a U sequence in subsequent amplification steps performed in substantially isothermal conditions to make amplification products that contain a U sequence that indicates the presence of the target nucleic acid in a sample.Type: GrantFiled: December 20, 2007Date of Patent: June 12, 2012Assignee: Gen-Probe IncorporatedInventors: Steven T. Brentano, Dmitry Lyakhov, James D. Carlson, Norman C. Nelson, Lyle J. Arnold, Jr.
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Patent number: 8124335Abstract: Methods for detecting influenza virus A and influenza virus B nucleic acids in biological samples by using in vitro amplification and detection are disclosed. Compositions that are target-specific nucleic acid sequences and kits comprising target-specific nucleic acid oligomers for amplifying in vitro influenza virus A or influenza virus B nucleic acid and detecting amplified nucleic acid sequences are disclosed.Type: GrantFiled: May 4, 2006Date of Patent: February 28, 2012Assignee: Gen-Probe IncorporatedInventors: Elizabeth M. Marlowe, Paul M. Darby, Damon K. Getman, Sylvia A. Norman, Reinhold B. Pollner
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Patent number: 8063197Abstract: Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences are disclosed.Type: GrantFiled: April 24, 2009Date of Patent: November 22, 2011Assignee: Gen-Probe IncorporatedInventors: James D. Carlson, Steven T. Brentano
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Patent number: 8034554Abstract: Methods of the invention separate a target nucleic acid from a sample by using at least one capture probe oligonucleotide that contains a target-complementary region and a member of a specific binding pair that attaches the target nucleic acid to an immobilized probe on a capture support, thus forming a capture hybrid that is separated from other sample components before the target nucleic acid is released from the capture support and hybridized to a detection probe to form a detection hybrid that produces a detectable signal that indicates the presence of the target nucleic acid in the sample. Compositions for practicing the methods of the invention include a capture probe oligonucleotide made up a target-complementary region sequence and a covalently linked capture region sequence that includes a member of a specific binding pair.Type: GrantFiled: June 29, 2005Date of Patent: October 11, 2011Assignee: Gen-Probe IncorporatedInventors: Michael M. Becker, Mehrdad R. Majlessi
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Patent number: 8026066Abstract: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.Type: GrantFiled: December 21, 2009Date of Patent: September 27, 2011Assignee: Gen-Probe IncorporatedInventors: Sylvia A. Norman, Jennifer J. Bungo, William L. Hanna, Neeraj P. Rao
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Patent number: 7879581Abstract: Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting Mycobacterium species using the oligonucleotides in in vitro nucleic acid amplification are disclosed.Type: GrantFiled: November 12, 2007Date of Patent: February 1, 2011Assignees: Gen-Probe Incorporated, BioMerieux S.A.Inventors: Steven T. Brentano, Markus T. Jucker, Francisco D. Delgado, Philippe Cleuziat, Marc Rodrigue
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Patent number: 7741027Abstract: Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.Type: GrantFiled: April 9, 2008Date of Patent: June 22, 2010Assignees: Gen-Probe Incorporated, BioMerieux S.A.Inventors: Yeasing Y. Yang, Steven T. Brentano, Odile Babola, Nathalie Tran, Guy Vernet
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Patent number: 7723040Abstract: Nucleic acid sequences and methods for detecting HIV-1 nucleic acid (LTR and pol sequences) in biological samples by detecting amplified nucleic acids are disclosed. Kits comprising nucleic acid oligomers for amplifying HIV-1 nucleic acid present in a biological sample and detecting the amplified nucleic acid are disclosed.Type: GrantFiled: September 4, 2008Date of Patent: May 25, 2010Assignee: Gen-Probe IncorporatedInventors: Gary G. Bee, Yeasing Y. Yang, Dan Kolk, Cristina Giachetti, Sherrol H. McDonough
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Patent number: 7682792Abstract: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.Type: GrantFiled: October 29, 2007Date of Patent: March 23, 2010Assignee: Gen-Probe IncorporatedInventors: Sylvia A. Norman, Jennifer J. Bungo, William L. Hanna, Neeraj P. Rao
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Patent number: 7544792Abstract: Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences are disclosed.Type: GrantFiled: July 13, 2005Date of Patent: June 9, 2009Assignee: Gen-Probe IncorporatedInventors: James D. Carlson, Steven T. Brentano
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Patent number: 7494774Abstract: The invention includes compositions and methods of detection of Bacillus anthracis that use oligonucleotide probes specific for genetic material contained in the pXO1 and pXO2 plasmids in nucleic acid hybridization reactions. Embodiments of the method may include additional probes specific for other gene sequences to distinguish B. anthracis from other bacterial species present in a sample or to provide an indication that the assay was performed properly even when no Bacillus sequence is detected.Type: GrantFiled: November 12, 2003Date of Patent: February 24, 2009Assignee: Gen-Probe IncorporatedInventors: Sylvia Ann Norman, Jennifer Jill Bungo, James J. Hogan, William G. Weisburg
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Patent number: 7470512Abstract: The present invention describes oligonucleotides targeted to HPV Type 16 and/or Type 18 nucleic acid sequences which are particularly useful to aid in detecting HPV type 16 and or 18. The oligonucleotides can aid in detecting HPV Type 16 and/or Type 18 in different ways such as by acting as hybridization assay probes, helper probes, and/or amplification primers.Type: GrantFiled: June 23, 2003Date of Patent: December 30, 2008Assignee: Gen-Probe IncorporatedInventors: Patricia Gordon, Nick M. Carter, Steven T. Brentano, Philip W. Hammond
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Patent number: 7425417Abstract: Nucleic acid sequences and methods for detecting HIV-1 nucleic acid (LTR and pol sequences) in biological samples by detecting amplified nucleic acids are disclosed. Kits comprising nucleic acid oligomers for amplifying HIV-1 nucleic acid present in a biological sample and detecting the amplified nucleic acid are disclosed.Type: GrantFiled: July 24, 2006Date of Patent: September 16, 2008Assignee: Gen-Probe IncorporatedInventors: Gary G. Bee, Yeasing Y. Yang, Dan Kolk, Cristina Giachetti, Sherrol H. McDonough
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Patent number: 7374877Abstract: Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.Type: GrantFiled: June 3, 2005Date of Patent: May 20, 2008Assignees: Gen-Probe Incorporated, BioMerieux S.A.Inventors: Yeasing Y. Yang, Steven T. Brentano, Odile Babola, Nathalie Tran, Guy Vernet
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Patent number: 7361746Abstract: Methods of detecting Mycobacterium avium complex (MAC) organisms using in vitro nucleic acid amplification with amplification oligonucleotides specific for 16S rRNA or DNA sequences encoding 16S rRNA from MAC species are disclosed. Compositions and kits containing oligonucleotides for amplifying and detecting 16S rRNA or DNA sequences encoding 16S rRNA from MAC species are disclosed.Type: GrantFiled: June 4, 2004Date of Patent: April 22, 2008Assignee: Gen-Probe IncorporatedInventors: Steven T. Brentano, Roger L. Lankford
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Patent number: 7354719Abstract: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.Type: GrantFiled: December 8, 2005Date of Patent: April 8, 2008Assignee: Gen-Probe IncorporatedInventors: Sylvia A. Norman, Jennifer J. Bungo, William L. Hanna, Neeraj P. Rao
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Patent number: 7355034Abstract: The present invention describes oligonucleotides targeted to HPV Type 16 and/or Type 18 nucleic acid sequences which are particularly useful to aid in detecting HPV type 16 and or 18. The oligonucleotides can aid in detecting HPV Type 16 and/or Type 18 in different ways such as by acting as hybridization assay probes, helper probes, and/or amplification primers.Type: GrantFiled: June 26, 2003Date of Patent: April 8, 2008Assignee: Gen-Probe IncorporatedInventors: Patricia Gordon, Nick M. Carter, Steven T. Brentano, Philip W. Hammond
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Patent number: 7326532Abstract: A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. Tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences by using probes that provide information by their specific hybridization to portions of the amplified nucleic acid is disclosed. Compositions for amplifying and detecting in vitro the rpoB sequences of M. Tuberculosis in a sample are disclosed.Type: GrantFiled: July 28, 2006Date of Patent: February 5, 2008Assignees: Gen-Probe Incorporated, BioMerieux S.A.Inventors: Markus T. Jucker, Steven T. Brentano, Francisco D. Delgado, Philippe Cleuziat
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Patent number: 7326533Abstract: A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences by using probes that provide information by their specific hybridization to portions of the amplified nucleic acid is disclosed. Compositions for amplifying and detecting in vitro the rpoB sequences of M. tuberculosis in a sample are disclosed.Type: GrantFiled: July 27, 2006Date of Patent: February 5, 2008Assignees: Gen-Probe Incorporated, BloMorloux S.A.Inventors: Markus T. Jucker, Steven T. Brentano, Francisco D. Delgado, Philippe Cleuziat