Abstract: The invention provides a method for delivering biologically active molecules to the eye by implanting biocompatible capsules containing a cellular source of the biologically active molecule. Also provided is a method of treating ophthalmic diseases using biocompatible capsules.
Type:
Grant
Filed:
August 20, 2002
Date of Patent:
November 18, 2003
Assignee:
Neurotech S.A.
Inventors:
Joseph P. Hammang, E. Edward Baetge, William G. Tsiarias, Peter D. Spear
Abstract: The invention provides methods of transplanting multipotent neural stem cell progeny to a host by obtaining a population of cells derived from mammalian neural tissue containing at least one multipotent CNS multipotent neural stem cell; culturing the neural stem cell in a culture medium containing one or more growth factors which induce multipotent neural stem cell proliferation; inducing proliferation of the multipotent neural stem cell to produce neural stem cell progeny which includes multipotent neural stem cell progeny cells; and transplanting the multipotent neural stem cell progeny to the host.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
December 24, 2002
Assignee:
NeuroSpheres Holdings Ltd.
Inventors:
Samuel Weiss, Brent Reynolds, Joseph P. Hammang, E. Edward Baetge