Patents Represented by Attorney Christopher J. Smith

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  • Serine protease inhibitors
    Patent number: 7381734
    Abstract: Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: June 3, 2008
    Assignee: Tularik Limited
    Inventors: Sarah Elizabeth Lively, Bohdan Waszkowycz, Martin James Harrison, Christopher Neil Farthing, Keith Michael Johnson
  • Bis-aryl thiazole derivatives
    Patent number: 7358267
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the invention modulate the expression and/or activity of UCP3.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: April 15, 2008
    Assignee: Amgen Inc.
    Inventors: M. Catherine Amaral, Jin-Long Chen, Juan C. Jaen, David N. Johnston, Paul Rafferty
  • Methods of modulating appetite using agouti-related transcript polypeptides
    Patent number: 7122520
    Abstract: Disclosed is a novel gene termed ART which is expressed primarily in selected regions of the brain, as well as adrenal and lung tissues. Polypeptides encoded by ART are also disclosed, as are methods for preparing ART DNA and amino acid sequences.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: October 17, 2006
    Assignee: Amgen Inc.
    Inventor: Kevin Lee Stark
  • Solid-phase synthesis of N-alkyl amides
    Patent number: 5861532
    Abstract: Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: January 19, 1999
    Assignee: Chiron Corporation
    Inventors: Edward G. Brown, John M. Nuss