Abstract: The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.
Type:
Grant
Filed:
April 7, 2005
Date of Patent:
March 16, 2010
Assignee:
Genzyme Corporation
Inventors:
Caroline Isabelle Bacon Kurtz, Richard Fitzpatrick
Abstract: A method for drying a material such as a polymer hydrogel which passes through a cohesive phase as it dries is disclosed. The method comprises agitating a composition while removing liquid until the solids content of the composition reaches a level at which the composition enters a cohesive phase, halting agitation, removing liquid from the composition in the absence of agitation, and resuming agitation. Practice of the present invention can eliminate the problems associated with adhesion of a material to itself and to process equipment during the cohesive phase.
Abstract: Disclosed is a pharmaceutical composition comprising a stable polyallylamine hydrochloride polymer in which between about 4% to about 12% by weight of the polymer is a chloride anion and a pharmaceutically acceptable carrier or diluent.
Type:
Grant
Filed:
April 17, 2002
Date of Patent:
June 2, 2009
Assignee:
Genzyme Corporation
Inventors:
John S. Petersen, Steven K. Burke, Stephen Randall Holmes-Farley