Patents Represented by Attorney, Agent or Law Firm Christopher P. Rogers
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Patent number: 6673930Abstract: The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolines.Type: GrantFiled: November 7, 2002Date of Patent: January 6, 2004Inventors: Yi-Yin Ku, Timothy A. Grieme, Padam N. Sharma, Prasad S. Raje, Howard E. Morton, Mike A. Fitzgerald
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Patent number: 6627767Abstract: or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.Type: GrantFiled: August 22, 2001Date of Patent: September 30, 2003Assignee: Abbott LaboratoriesInventors: Gang Liu, Yihong Li, David A. Janowick, Zhonghua Pei
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Patent number: 6608216Abstract: The present invention relates to the preparation of chiral glucocorticoid receptor agents via biaryl atropisomers.Type: GrantFiled: June 28, 2002Date of Patent: August 19, 2003Assignee: Abbott LaboratoriesInventors: Yi-Yin Ku, Tim Grieme, Howard E. Morton, Steven A. King
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Patent number: 6593480Abstract: Compounds of formula I are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.Type: GrantFiled: February 28, 2001Date of Patent: July 15, 2003Assignee: Abbott LaboratoriesInventors: Philip R. Kym, Benjamin C. Lane, John K. Pratt, Tom Von Geldern, Martin Winn, Jehrod Brenneman, Jyoti R. Patel, David L. Arendsen, Irini Akritopoulou-Zanze, Kimba L. Ashworth, Kresna Hartandi
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Patent number: 6583180Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof are novel glucocorticoid receptor modulators and are useful for treating type II diabetes in a mammal.Type: GrantFiled: February 8, 2002Date of Patent: June 24, 2003Assignee: Abbott LaboratoriesInventors: James T. Link, Bryan K. Sorensen, Jyoti R. Patel, David L. Arendsen, Gaoquan Li
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Patent number: 6579882Abstract: Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.Type: GrantFiled: March 6, 2001Date of Patent: June 17, 2003Assignee: Abbott LaboratoriesInventors: Andrew O. Stewart, Steven A. Boyd, David L. Arendsen, Pramila Bhatia, Kevin R. Condroski, Jennifer C. Freeman, Indrani W. Gunawardana, Gui-Dong Zhu, Kraig Lartey, Catherine M. McCarty, Nicholas A. Mort, Meena V. Patel, Michael A. Staeger, David M. Stout
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Patent number: 6558651Abstract: This invention relates to aerosol formulations of use for the administration of medicaments by inhalation. More particularly, the invention relates to a pharmaceutical aerosol formulation which comprises particulate salbutamol sulphate having a crystalline form in which the outer layer of the crystals is substantially non-amorphous; and 1,1,1,2-tetrafluoroethane. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of a pharmaceutical aerosol formulation as defined is also described.Type: GrantFiled: June 18, 1998Date of Patent: May 6, 2003Assignee: SmithKline Beecham CorporationInventors: Michael Thomas Riebe, Sarvajna Kumar Dwivedi, Li Li-Bovet
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Patent number: 6482390Abstract: A hand held apparatus and method for creating an aerosolized mist of particles is described. The apparatus comprises a high pressure vessel containing a solution or suspension of the substance to be aerosolized in a high pressure liquefied gas, a manually actuatable valve and a spray nozzle. The high pressure liquefied gas is in a sub-critical state.Type: GrantFiled: December 20, 1999Date of Patent: November 19, 2002Assignee: SmithKline Beecham CorporationInventors: Peter Gerard Hiscocks, David Laurence Gee
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Patent number: 6474331Abstract: There is provided a dispenser suitable for dispensing medicament, particularly medicament for use in the treatment of respiratory disorders. The dispenser comprises a housing (1) having a support (5); a container (2), locatable within said housing (1), having an outlet (3), wherein said container (2) dispenses through said outlet (3) in response to movement of the container (2), relative to the housing (1); and an actuation indicator having an indexing mechanism (13, 43) actuatable by movement of the container (2) relative to the housing (1). A couple mechanism (13, 43) is provided which couples the indexing mechanism (13, 43) to the container (2) to compensate for any variation in pre-actuation positionings of the indexing mechanism and container.Type: GrantFiled: March 31, 2000Date of Patent: November 5, 2002Assignee: Smithkline Beecham CorporationInventors: Paul Kenneth Rand, Peter John Brand, James William Godfrey
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Patent number: 6474513Abstract: The invention is directed to a valve for an aerosol container for dispersing a suspension or solution of a medicament in a liquid propellant contained therein. The valve comprises a valve body defining an aperture, a seal mounted at the aperture, and a valve stem having a dispensing passage. The valve stem being slideably moveable through the seal such that in a first position the valve is closed to prevent the medicament and propellant from entering the dispensing passage. The valve stem also being such that in a second position the valve is open to allow the substance to be dispensed through the dispensing passage. The valve stem characterized in that it is constructed from a mouldable plastic and a mouldable lubricant.Type: GrantFiled: November 16, 2001Date of Patent: November 5, 2002Assignee: SmithKline Beecham CorporationInventor: Peter Colin Weston Burt
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Patent number: 6450969Abstract: A device having variable inspiratory resistance suitable for measuring the inspiratory strength of a patient which comprises a chamber in communication with a mouthpiece. The chamber is provided with a calibration system for measuring the inhalation flow rate during inhalation through the mouthpiece. The calibration system is also provided with a variable resistance feature where the airflow resistance may be altered.Type: GrantFiled: January 5, 2001Date of Patent: September 17, 2002Assignee: SmithKline Beecham CorporationInventors: Philip William Farr, Thomas Paul McCarthy
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Patent number: 6451287Abstract: Amphiphilic fluorinated block copolymers are disclosed which are useful for increasing the dispersability of particles, preferably drug particles, in a fluorine-containing propellant.Type: GrantFiled: May 26, 2000Date of Patent: September 17, 2002Assignee: Smithkline Beecham CorporationInventors: Joseph M. Desimone, Terri Johnson Carson, John F. Miller, Sharon Wells
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Patent number: 6431168Abstract: There is provided a dispenser suitable for dispensing medicament, particularly medicament for use in the treatment of respiratory disorders. The dispenser comprises a housing (1) having a support (5); a container (2), locatable within said housing (1), having an outlet member, wherein said container (2) is movable relative to the housing (1) to enable dispensing therefrom and said outlet member is connectable with said support (5) to prevent relative movement there-between; and a dose indicator (13, 43), locatable within said housing (1). The container (2) and dose indicator (13, 43) are reversably removable from the housing (1) as a single unit.Type: GrantFiled: March 13, 2000Date of Patent: August 13, 2002Assignee: Smithkline Beecham CorporationInventors: Paul Kenneth Rand, Peter John Brand, James William Godfrey, Stanley George Bonney
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Patent number: 6426337Abstract: There are provided according to the invention novel compounds of formula (I) wherein R1, R2, and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.Type: GrantFiled: August 20, 1999Date of Patent: July 30, 2002Assignee: SmithKline Beecham CorporationInventors: Brian Cox, Suzanne Elaine Keeling, David George Allen, Alison Judith Redgrave, Michael David Barker, Heather Hobbs, Thomas Davis Roper, IV, Joanna Victoria Geden
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Patent number: 6397115Abstract: A computer based hazardous material classification and compliance system and method that provides material classification, specification, documentation and instructions to properly process, package and transport regulated and non-regulated materials. The hazardous material classification and compliance system and method includes three integrated primary modules, a plurality of related subsystems and a plurality of databases. The modules include a scheduling module which allows the user to schedule the processing of a material request, a classification module which allows the user to automatically classify a material, and a packaging module which allows the user to identify and order the necessary materials to package and ship a material.Type: GrantFiled: October 8, 1999Date of Patent: May 28, 2002Assignee: SmithKline BeechamInventor: Richard A. Basden
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Patent number: 6390291Abstract: A method and package for storing a pressurized container which is filled with a drug formulation at a predetermined pressure. The drug formulation includes a mixture of a drug and a propellant. The package which encloses the pressurized container substantially prevents ingression of water vapor and particulate matter into the package while permitting egression of the propellant which may leak from the pressurized container.Type: GrantFiled: May 15, 2000Date of Patent: May 21, 2002Assignee: SmithKline Beecham CorporationInventors: Karl Andrew Garrill, Richard J. Haan, Craig Steven Herman, Richard Ian Walker
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Patent number: 6360739Abstract: There is provided a dispenser suitable for dispensing medicament, particularly medicament for use in the treatment of respiratory disorders. The dispenser comprises a housing (1) having a support (5), a container (2), locatable within said housing (1), having an outlet (3), wherein said container (2) dispenses through said outlet (3) in response to movement of the container (2) relative to the housing (1) and an actuation indicator having an indexing mechanism (13,43) actutable by movement of the container (2) relative to the housing (1). The indexing mechanism (13, 43) includes a coupling element to compensate for excess movement of the container (2) relative to the housing (1).Type: GrantFiled: March 31, 2000Date of Patent: March 26, 2002Assignee: SmithKline Beecham CorporationInventors: Paul Kenneth Rand, Peter John Brand, James William Godfrey
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Patent number: 6352152Abstract: A method and package for storing a pressurized container which is filled with a drug formulation at a predetermined pressure. The drug formulation includes a mixture of a drug and a propellant. The package which encloses the pressurized container substantially prevents ingression of water vapor and particulate matter into the package while permitting egression of the propellant which may leak from the pressurized container.Type: GrantFiled: June 20, 2000Date of Patent: March 5, 2002Assignee: Smithkline Beecham CorporationInventors: Gregor John McLennan Anderson, Karl Andrew Garrill, Richard J. Haan, Craig Steven Herman, Vincent P. Pisculli, Richard Ian Walker
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Patent number: 6345740Abstract: The invention is directed to a valve for an aerosol container for dispersing a suspension or solution of a medicament in a liquid propellant contained therein. The valve comprises a valve body defining an aperture, a seal mounted at the aperture, and a valve stem having a dispensing passage. The valve stem being slideably moveable through the seal such that in a first position the valve is closed to prevent the medicament and propellant from entering the dispensing passage. The valve stem also being such that in a second position the valve is open to allow the substance to be dispensed through the dispensing passage. The valve seal characterized in that it is constructed from a nitrile-containing rubber and micronized fluorine-containing polymer.Type: GrantFiled: December 16, 1999Date of Patent: February 12, 2002Assignee: Glaxo Wellcome Inc.Inventor: Michael Thomas Riebe
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Patent number: D456504Type: GrantFiled: February 26, 2001Date of Patent: April 30, 2002Assignee: SmithKline BeechamInventors: Duncan Robertson, Gary Robert Beaumont, George Alan Robusti