Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
Type:
Grant
Filed:
June 23, 2006
Date of Patent:
September 4, 2007
Assignee:
Pfizer, Inc.
Inventors:
Todd A. Blumenkopf, Mark E. Flanagan, Michael J. Munchhof