Patents Represented by Attorney Cindy A. Lynch
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Patent number: 7279004Abstract: An expandable tissue supporting device of the present invention employs ductile hinges at selected points in the expandable device. When expansion forces are applied to the device as a whole, the ductile hinges concentrate expansion stresses and strains in small well defined areas. The expandable medical device including ductile hinges provides the advantages of low expansion force requirements, relatively thick walls which are radio-opaque, improved crimping properties, high crush strength, reduced elastic recoil after implantation, and control of strain to a desired level. The expandable tissue supporting device includes a plurality of elongated beams arranged in a cylindrical device and connected together by a plurality of ductile hinges.Type: GrantFiled: December 4, 2003Date of Patent: October 9, 2007Assignee: Innovational Holdings, LLC.Inventor: John F. Shanley
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Patent number: 7208011Abstract: The present invention relates to implantable medical devices for delivery of therapeutic agents, such as drugs, to a patient. More particularly, the invention relates to a device having therapeutic agents protected by a protective layer that prevents or retards processes that deactivate or degrade the active agents.Type: GrantFiled: September 23, 2002Date of Patent: April 24, 2007Assignee: Conor Medsystems, Inc.Inventors: John F. Shanley, Theodore L. Parker
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Patent number: 7208010Abstract: An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.Type: GrantFiled: September 7, 2001Date of Patent: April 24, 2007Assignee: Conor Medsystems, Inc.Inventors: John F. Shanley, Neal L. Eigler, Kinam Park, Elazer R. Edelman
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Patent number: 7202370Abstract: A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.Type: GrantFiled: October 27, 2003Date of Patent: April 10, 2007Assignee: Conor Medsystems, Inc.Inventor: Ragina Naidu
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Patent number: 7179288Abstract: An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, and the plurality of struts each having a strut width in a circumferential direction. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of said strut. A beneficial agent may be loaded into the opening within the strut. The expandable medical device may further include a plurality of ductile hinges formed between the elongated struts, the ductile hinges allowing the cylindrical device to be expanded or compressed from the first diameter to the second diameter by deformation of the ductile hinges.Type: GrantFiled: June 5, 2003Date of Patent: February 20, 2007Assignee: Conor Medsystems, Inc.Inventor: John F. Shanley
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Patent number: 7179289Abstract: An expandable medical device has a plurality of elongated struts, the plurality of elongated struts being joined together to form a substantially cylindrical device. The device is expandable from a cylinder having a first diameter to a cylinder having a second diameter, and the plurality of struts each having a strut width in a circumferential direction. At least one of the struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent can be loaded into the opening within the strut. The expandable medical device may further include a plurality of ductile hinges formed between the elongated struts, the ductile hinges allowing the cylindrical device to be expanded or compressed from the first diameter to the second diameter by deformation of the ductile hinges.Type: GrantFiled: June 7, 2004Date of Patent: February 20, 2007Assignee: Conor Medsystems, Inc.Inventor: John F. Shanley
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Patent number: 7169179Abstract: A drug delivery device is provided with openings for directional delivery of a plurality of therapeutic agents to blood vessels or other lumens or organs. In particular, the invention relates to the delivery of different therapeutic agents, different quantities of therapeutic agents, or different release profiles of the same or different therapeutic agents in different directions from the drug delivery device. The invention is useful, for example, for delivering antirestenotic, antithrombotic, antiplatelet, antiproliferative, antineoplastic, immunosuppressive, angiogenic, anti-inflammatory, or antiangiogenic agents and/or vasodilators to a blood vessel. In one embodiment, antiproliferative, antineoplastic, angiogenic, antiangiogenic, anti-inflammatory, and/or antirestenotic agents are delivered to the wall of a blood vessel and antithrombotic agents, antiplatelet agents, and/or vasodilators are delivered to the lumen of a blood vessel.Type: GrantFiled: June 5, 2003Date of Patent: January 30, 2007Assignee: Conor Medsystems, Inc.Inventors: John F. Shanley, Theodore L. Parker
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Patent number: 7160321Abstract: An expandable medical device includes elongated struts which are joined together to form a substantially cylindrical device. The device is expandable from a cylinder having a first diameter to a cylinder having a second diameter. Each of the struts has a width in a circumferential direction and a thickness. At least one of the struts includes at least one opening that extends at least partially through the strut's thickness. A beneficial agent may be loaded into the opening within the strut. The expandable medical device may also include ductile hinges, formed between the elongated struts, which deform to allow the cylindrical device to be expanded or compressed from the first diameter to the second diameter.Type: GrantFiled: June 15, 2004Date of Patent: January 9, 2007Assignee: Conor Medsystems, Inc.Inventor: John F. Shanley
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Patent number: 7056338Abstract: The present invention relates to implantable medical devices for the localized delivery of therapeutic agents, such as drugs, to a patient. More particularly, the invention relates to a device having a gradient of water soluble therapeutic agents within a therapeutic agent layer and a mixing layer that allows for controlled release of the therapeutic agents.Type: GrantFiled: March 28, 2003Date of Patent: June 6, 2006Assignee: Conor Medsystems, Inc.Inventors: John F. Shanley, Theodore L. Parker
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Patent number: 6964680Abstract: According to the present invention there is provided an expandable medical device having, a plurality of elongated beams, the plurality of elongated beams joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. A plurality of hinges connecting the elongated beams have a hinge width, wherein the hinge width is smaller than the beam width. A pawl is disposed adjacent to and substantially parallel to the hinge prior to expansion of the medical device and a plurality of teeth are adapted to receive the pawl. The present invention additionally provides the benefit of limiting the amount of recoil of an expandable device by engaging a locking mechanism, thereby retaining the expanded diameter of the device.Type: GrantFiled: January 25, 2002Date of Patent: November 15, 2005Assignee: Conor Medsystems, Inc.Inventor: John F. Shanley
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Patent number: 6855125Abstract: A delivery system and method are provided for accurately locating, orienting, and implanting expandable tissue supporting devices at a lumen junction or bifurcation in a body lumen. For example, the system may be used to deliver a tissue supporting device to a bifurcated artery such that, on expansion, the tissue supporting device provides side ports of a specific size and geometry to accommodate bifurcations in the artery. The delivery system is capable of accurately orienting these side ports both radially and longitudinally with respect to branch lumen openings of the artery. The delivery system achieves orientation by utilizing a guide member which is positioned to extend from the side port feature of the tissue supporting device. The guide member is tracked along a guidewire which extends into the branch lumen, ultimately orienting the side port of the tissue supporting device properly at the branch lumen opening.Type: GrantFiled: May 31, 2001Date of Patent: February 15, 2005Assignee: Conor Medsystems, Inc.Inventor: John F. Shanley
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Patent number: 6786914Abstract: An anastomosis device is a one piece device for connecting a graft vessel to a target vessel without the use of conventional sutures. The anastomosis device includes an expandable tube configured to have a graft vessel secured to the tube. The device has an expandable linkage positioned at one end of the device and expansion of this linkage causes a first radially extending flange to fold outward. This first flange abuts an interior wall of a target vessel and a second flange is formed which abuts an exterior wall of the target vessel trapping the target vessel between the two flanges and secures the end of the graft vessel into an opening in the wall of the target vessel. The device greatly increases the speed with which anastomosis can be performed over known suturing methods and allows anastomosis to be performed in tight spaces.Type: GrantFiled: September 18, 2000Date of Patent: September 7, 2004Assignee: Cardica, Inc.Inventors: Jaime Vargas, Stephen A. Yencho, Jamey Nielsen, Michael Hendricksen, Bernard A. Hausen
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Patent number: 6776785Abstract: A one piece anastomosis device is disclosed which is formed of a superelastic or pseudoelastic material which self deforms or self deploys from an insertion configuration to a tissue holding configuration. The device in a deployed state preferably includes an inner tissue penetrating flange which penetrate and retains an everted graft vessel and an outer flange. The self deploying anastomosis device does not rely on a temperature transformation to achieve deployment.Type: GrantFiled: October 12, 2000Date of Patent: August 17, 2004Assignee: Cardica, Inc.Inventors: Stephen Yencho, Jaime Vargas
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Patent number: 6764507Abstract: An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together by ductile hinges to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. The plurality of struts and ductile hinges are arranged to improve the spatial distribution of the struts which is particularly important when delivering beneficial agents with the struts. The improved strut arrangement expands to a substantially parallelogram shape for improved beneficial agent distribution to the surrounding tissue. A beneficial agent may be loaded into openings within the struts or coated onto the struts for delivery to the tissue.Type: GrantFiled: September 7, 2001Date of Patent: July 20, 2004Assignee: Conor Medsystems, Inc.Inventors: John F. Shanley, Neal L. Eigler, Elazer R. Edelman
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Patent number: 6719769Abstract: An integrated anastomosis tool both creates an opening in a side wall of a target blood vessel and performs an anastomosis procedure to connect a graft vessel to a side of the target blood vessel with a single integrated tool. The integrated anastomosis tool includes a cutting device, a graft vessel attachment device, an introducer, and a tool body. In each of the embodiments of the anastomosis tool, the advancement paths of a cutting device and a graft vessel attachment device cross, intersect, or align so that both the cutting device and the graft vessel attachment device can be operated by a single tool at the same intended anastomosis site in a sequential manner. The anastomosis procedure can be performed on a pressurized vessel since there is no need to interchange tools during the procedure.Type: GrantFiled: December 5, 2001Date of Patent: April 13, 2004Assignee: Cardica, Inc.Inventors: Brendan M. Donohoe, Jaime Vargas, Stephen A. Yencho, James T. Nielsen, Theodore M. Bender, Michael Hendricksen, Scott C. Anderson
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Patent number: 6673088Abstract: A tissue punch for creating a hole in the wall of a target blood vessel for receiving an anastomosis device includes a piercing element for penetrating the tissue and a cutting element for cutting a plug of tissue around the pierced hole. The tissue punch includes a trocar for inserting the piercing element. After punching is complete, the piercing element is removed from the trocar through a side wall of the trocar so that a medical device can be deployed through the trocar lumen. The tissue punch may also include a tissue trap for trapping the plug of tissue.Type: GrantFiled: April 4, 2000Date of Patent: January 6, 2004Assignee: Cardica, Inc.Inventors: Jaime Vargas, Brendan M. Donohoe, Scott C. Anderson, Theodore Bender, Stephen Yencho, Bernard Hausen, Michael Hendricksen, James T. Nielsen
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Patent number: 6537287Abstract: The anastomosis device according to the present invention is a one piece device for connecting a graft vessel to a target vessel without the use of conventional sutures. The anastomosis device includes a frame for receiving and holding the end of a graft vessel in an everted position and first and second spreading members configured to be inserted into an opening in the target vessel. The first and second spreading members are arranged substantially in a plane for insertion into an opening in a target vessel, and are moved away from one another to capture the edges of the opening in the target vessel securing the graft vessel to the target vessel. One version of the anastomosis device includes a plurality of linkages arranged in two rows for grasping opposite sides of an opening in the target vessel. A portion of the linkages fold outward to trap vessel walls on opposite sides of the opening in the target vessel.Type: GrantFiled: November 6, 2000Date of Patent: March 25, 2003Assignee: Cardica, Inc.Inventors: Stephen A. Yencho, Michael Hendricksen, Jaime Vargas, Jamey Nielsen, Bernard A. Hausen, Scott Vance
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Patent number: D516723Type: GrantFiled: July 6, 2004Date of Patent: March 7, 2006Assignee: Conor Medsystems, Inc.Inventor: John F. Shanley
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Patent number: D523558Type: GrantFiled: April 26, 2005Date of Patent: June 20, 2006Assignee: Conor Medsystems, Inc.Inventor: John F. Shanley
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Patent number: RE39800Abstract: The present invention discloses a method for the prevention of atherosclerosis, its genesis, progression and restenosis in human patients undergoing treatments for arterial lesions such as PTA or atherectomy, and which may be accompanied by stent implantation. Further, the treatment method disclosed has applicability in all stages of atherosclerosis in which monocytes play a role. The compound utilized in the present method as the active agent is a 2-halo-2?-deoxyadenosine such as 2-chloro-deoxyadenosine (2-CdA). The treatment method of the present invention includes the administration of 14 doses of 2-CdA in the amount of 0.12 mg/kg. One dose is given intravenously before the coronary intervention, another is given intravenously after the intervention and the remaining twelve doses are given subcutaneously at weekly intervals over a subsequent three month period.Type: GrantFiled: February 18, 2004Date of Patent: August 28, 2007Assignee: Conor Medsystems, Inc.Inventors: Richard A. Schatz, Alan Saven